Butan-1-amine

C4H11N

butan-1-amine

CAS109-73-9
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
109-73-9
EC Number
203-699-2
UN Number
1125
Index Number
612-005-00-0
PubChem CID
8007

Physical-chemical properties

Molecular Formula
C4H11N
Molar Mass
73.14 g/mol
IUPAC Name
butan-1-amine

Chemical Identifiers

InChI
InChI=1S/C4H11N/c1-2-3-4-5/h2-5H2,1H3
InChI Key
HQABUPZFAYXKJW-UHFFFAOYSA-N

Overview

Butan-1-amine (CAS 109-73-9) is a primary aliphatic amine with flammable properties and corrosive characteristics. This linear four-carbon amine represents a fundamental building block in organic synthesis and industrial chemistry, offering versatile reactivity through its terminal amino group. As a primary amine, butan-1-amine exhibits typical nucleophilic behavior, readily participating in alkylation, acylation, and condensation reactions. The compound appears as a colorless liquid with a characteristic ammonia-like odor, demonstrating good solubility in both polar and moderately polar solvents. Its molecular structure provides an optimal balance between hydrophobic alkyl chain length and hydrophilic amino functionality, making it particularly valuable in surfactant chemistry and intermediate synthesis. From a safety perspective, butan-1-amine requires careful handling due to its classification as a flammable liquid and skin corrosive substance. The compound poses acute toxicity risks and demands appropriate personal protective equipment and ventilation systems during use. Storage must comply with flammable liquid regulations while preventing exposure to incompatible materials such as strong acids and oxidizing agents. Industrial applications primarily include its use as a chemical intermediate in pharmaceutical synthesis, where it serves as a precursor for active pharmaceutical ingredients. The compound also finds application in the production of specialty surfactants and corrosion inhibitors for metalworking fluids. Additionally, butan-1-amine functions as a curing agent in epoxy systems and as a catalyst in polyurethane chemistry. Like other aliphatic amines such as N-ethylethanamine, it demonstrates excellent reactivity in forming stable chemical bonds with various electrophilic species. OYSI maintains reliable supply chains for butan-1-amine, ensuring consistent availability for European industrial customers requiring this essential chemical intermediate.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1125
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping Namen-Butylamin
Marine PollutantNo

Frequently Asked Questions

What is butan-1-amine?

Butan-1-amine is a primary aliphatic amine with the molecular formula C4H11N and CAS number 109-73-9. It consists of a four-carbon chain with an amino group (-NH2) attached to the terminal carbon. With a molecular weight of 73.14 g/mol, this compound is classified as a flammable liquid and corrosive substance, requiring careful handling due to its hazardous properties including acute toxicity and skin corrosion potential.

What are the physicochemical properties of butan-1-amine?

Butan-1-amine is a colorless liquid with a strong ammonia-like odor characteristic of primary amines. It is highly soluble in water due to its ability to form hydrogen bonds through the amino group. The compound has a relatively low boiling point typical of short-chain amines and exhibits basic properties in aqueous solution. Its flammable nature and volatile characteristics require proper ventilation and fire prevention measures during handling and storage.

What is butan-1-amine used for?

Butan-1-amine is primarily used as an intermediate in organic synthesis and chemical manufacturing. It serves as a building block for pharmaceuticals, agrochemicals, and specialty chemicals production. The compound is utilized in the synthesis of rubber accelerators, corrosion inhibitors, and surfactants. Additionally, it finds applications in the production of dyes, emulsifiers, and as a starting material for various nitrogen-containing compounds in industrial processes.

How to handle butan-1-amine safely?

Butan-1-amine requires strict safety measures due to its corrosive and toxic properties. Personal protective equipment must include chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation. Keep away from ignition sources due to its flammable nature. Ensure emergency eyewash stations and safety showers are readily accessible when handling this substance.

How to store butan-1-amine correctly?

Butan-1-amine must be stored in tightly sealed containers made of compatible materials, away from heat sources and ignition points. Storage areas should be cool, dry, and well-ventilated with appropriate fire suppression systems. Keep separate from incompatible materials such as strong acids, oxidizing agents, and reactive metals. Containers should be properly labeled and stored in secondary containment to prevent environmental release in case of spills or leaks.

What to do in case of contact with butan-1-amine?

Immediate action is required for any contact with butan-1-amine due to its corrosive properties. For skin contact, remove contaminated clothing and flush affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse immediately with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical care. Always consult a physician after exposure.

How to dispose of butan-1-amine appropriately?

Butan-1-amine disposal must comply with local and national hazardous waste regulations as it cannot be disposed of through regular waste streams. The substance should be collected in appropriate containers and handed over to licensed hazardous waste disposal companies. Neutralization may be required before disposal, following approved procedures. Empty containers must also be treated as hazardous waste. Never discharge into sewers, waterways, or soil due to environmental and safety concerns.

How to transport butan-1-amine?

Butan-1-amine is classified under ADR Class 3 (Flammable Liquids), Packing Group II, requiring specific transport procedures for dangerous goods. Vehicles must carry appropriate hazard placards and emergency response information. Drivers need ADR certification for dangerous goods transport. Packages must meet UN specification standards and be properly labeled with hazard symbols. Transport documents must include emergency contact information and proper shipping names according to dangerous goods regulations.

Is butan-1-amine subject to specific regulations?

Butan-1-amine is subject to multiple European regulations including REACH registration requirements and CLP classification obligations. It is not currently listed as a Substance of Very High Concern (SVHC) under REACH. The substance must be classified with appropriate GHS pictograms (GHS02, GHS07, GHS05) and carry the signal word 'Danger' on safety data sheets and labels. Industrial users must comply with occupational exposure limits and workplace safety regulations specific to their jurisdiction.

Where to buy butan-1-amine in Europe?

Butan-1-amine is available through OYSI, a European distributor specializing in technical chemicals and industrial raw materials. OYSI provides reliable supply chains across Europe with proper documentation including safety data sheets and certificates of analysis. The company ensures compliance with European chemical regulations and offers technical support for industrial applications. Contact OYSI directly for availability, specifications, and delivery options suited to your specific requirements and location within Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.