Cyclohexane

C6H12

cyclohexane

CAS110-82-7
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
110-82-7
EC Number
203-806-2
UN Number
1145
Index Number
601-017-00-1
PubChem CID
8078

Physical-chemical properties

Molecular Formula
C6H12
Molar Mass
84.16 g/mol
IUPAC Name
cyclohexane

Chemical Identifiers

InChI
InChI=1S/C6H12/c1-2-4-6-5-3-1/h1-6H2
InChI Key
XDTMQSROBMDMFD-UHFFFAOYSA-N

Overview

Cyclohexane (CAS 110-82-7) is a saturated cyclic hydrocarbon with excellent solvent properties and high flammability characteristics. This versatile aliphatic compound represents one of the most important cycloalkanes in industrial chemistry, featuring a six-membered carbon ring structure that exhibits remarkable stability and unique conformational behavior. With its molecular formula C6H12 and molecular weight of 84.16 g/mol, cyclohexane serves as a fundamental building block in petrochemical processes and specialized chemical manufacturing applications. The substance demonstrates significant safety considerations due to its classification as a highly flammable liquid (Category 2) and aspiration toxicant (Category 1), requiring careful handling protocols in industrial environments. Its volatility and lipophilic nature contribute to potential skin irritation effects, while environmental concerns arise from its acute and chronic aquatic toxicity profile. The presence of multiple GHS pictograms (GHS02, GHS08, GHS07, GHS09) emphasizes the comprehensive risk assessment required for safe handling and storage. Cyclohexane finds extensive application as a non-polar solvent in analytical chemistry and industrial extraction processes, where its selective dissolution properties prove invaluable. The compound serves as a crucial intermediate in nylon production through oxidation to cyclohexanol and cyclohexanone, representing a major industrial pathway. Additionally, it functions as a paint thinner and degreasing agent in specialized manufacturing operations. Within the broader category of saturated hydrocarbons, cyclohexane shares certain applications with branched alkanes such as 3-ethyl-3-methylpentane, though its cyclic structure provides distinct advantages in specific chemical processes. The compound's conformational flexibility, particularly its chair-boat equilibrium, makes it an essential reference standard in stereochemical studies. OYSI maintains reliable supply chains for high-purity cyclohexane to support diverse European industrial requirements.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Asp. Tox. 1; STOT SE 3; Skin Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H304

May be fatal if swallowed and enters airways.

H336

May cause drowsiness or dizziness.

H315

Causes skin irritation.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Irritant

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1145
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameCyclohexan
Marine PollutantNo

Frequently Asked Questions

What is cyclohexane?

Cyclohexane is a saturated cyclic hydrocarbon with the molecular formula C6H12 and CAS number 110-82-7. It consists of six carbon atoms arranged in a ring structure with twelve hydrogen atoms. With a molecular weight of 84.16 g/mol, cyclohexane is a colorless, flammable liquid at room temperature. It belongs to the cycloalkane family and is widely used as an industrial solvent and chemical intermediate in various manufacturing processes.

What are the physicochemical properties of cyclohexane?

Cyclohexane is a colorless liquid with a characteristic sweet, gasoline-like odor at room temperature. It has a boiling point of 80.7°C and a melting point of 6.6°C. The substance is practically insoluble in water but miscible with most organic solvents including alcohols, ethers, and hydrocarbons. It has a density of approximately 0.78 g/cm³ and exhibits low viscosity. Cyclohexane is highly volatile and forms flammable vapor-air mixtures.

What is cyclohexane used for?

Cyclohexane is primarily used as a solvent in the chemical industry and as an intermediate in organic synthesis. It serves as a key raw material for producing adipic acid and caprolactam, which are essential precursors for nylon manufacturing. Additionally, cyclohexane is employed in paint thinners, varnishes, and extraction processes. It also finds applications in analytical chemistry, rubber production, and as a non-polar solvent for various industrial cleaning operations.

How to handle cyclohexane safely?

Cyclohexane must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its skin irritation properties. Work should be conducted in well-ventilated areas or under fume extraction systems to prevent vapor inhalation. Eliminate all ignition sources as cyclohexane is highly flammable (Flam. Liq. 2). Avoid skin contact and inhalation, and never eat, drink, or smoke while handling this substance.

How to store cyclohexane correctly?

Cyclohexane should be stored in tightly closed containers in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Storage temperatures should remain below 25°C to minimize vapor formation. Keep containers away from incompatible materials such as strong oxidizing agents and acids. Storage areas must be equipped with appropriate fire suppression systems and spill containment measures. Ensure proper grounding and bonding of containers during transfer operations.

What to do in case of contact with cyclohexane?

In case of skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If cyclohexane gets in eyes, rinse immediately with plenty of clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air immediately and keep them at rest. If swallowed, do not induce vomiting and seek immediate medical attention due to aspiration toxicity risks.

How to dispose of cyclohexane properly?

Cyclohexane waste must be disposed of according to local and national hazardous waste regulations as it is classified as flammable and environmentally hazardous. Contact licensed waste disposal companies for proper collection and treatment. Never pour cyclohexane down drains, sewers, or onto the ground due to its aquatic toxicity. Small quantities may be suitable for solvent recovery or incineration at authorized facilities. Always consult local environmental authorities for specific disposal requirements.

How to transport cyclohexane?

Cyclohexane is classified as ADR Class 3 (flammable liquids), Packing Group II, requiring specialized dangerous goods transportation procedures. Packages must bear appropriate hazard labels and markings according to international transport regulations. Vehicles must carry emergency equipment and drivers need ADR certification. Transport containers should be properly sealed, labeled, and secured to prevent leakage. Shipping documents must include proper shipping names and emergency response information.

Is cyclohexane subject to particular regulations?

Cyclohexane is regulated under European REACH and CLP regulations, requiring safety data sheets and hazard communication. It is not currently listed as a Substance of Very High Concern (SVHC) under REACH. However, due to its classification as flammable liquid with aspiration toxicity and environmental hazards, it is subject to workplace exposure limits and environmental discharge restrictions. Industrial users must comply with occupational safety regulations and environmental permits.

Where to buy cyclohexane in Europe?

Cyclohexane is available through OYSI, a reliable European distributor of technical chemicals serving industrial customers across Europe. OYSI provides high-quality cyclohexane with proper documentation, safety data sheets, and regulatory compliance support. As a specialized chemical distributor, OYSI ensures reliable supply chains and technical expertise for industrial applications. Contact OYSI directly for pricing, availability, and delivery options tailored to your specific requirements and location within Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.