Cyclohexane

C6H12

cyclohexane

CAS110-82-7
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
110-82-7
EC Number
203-806-2
UN Number
1145
Index Number
601-017-00-1
PubChem CID
8078

Physical-chemical properties

Molecular Formula
C6H12
Molar Mass
84.16 g/mol
IUPAC Name
cyclohexane

Chemical Identifiers

InChI
InChI=1S/C6H12/c1-2-4-6-5-3-1/h1-6H2
InChI Key
XDTMQSROBMDMFD-UHFFFAOYSA-N

Overview

Cyclohexane (CAS 110-82-7) is a saturated cyclic hydrocarbon with high flammability and significant industrial solvent applications. This six-carbon alicyclic compound represents one of the most important saturated cycloalkanes in industrial chemistry, serving as a fundamental building block and solvent across multiple sectors. With its distinctive chair conformation and molecular formula C6H12, cyclohexane exhibits unique physical and chemical properties that make it invaluable for various technical applications. The compound's relatively simple structure belies its complex role in modern chemical processes, where its stability and selective reactivity prove essential. From a safety perspective, cyclohexane requires careful handling due to its classification as a highly flammable liquid with aspiration toxicity risks. The substance can cause skin irritation and poses specific target organ toxicity concerns, particularly affecting the central nervous system. Its environmental profile indicates acute and chronic aquatic toxicity, necessitating appropriate containment and disposal measures. These hazard characteristics, indicated by GHS pictograms for flammability, health hazards, and environmental dangers, require comprehensive risk management protocols in industrial settings. Cyclohexane finds primary application as a solvent in the production of adipic acid and caprolactam, both crucial intermediates for nylon manufacturing. Additionally, it serves as an extraction solvent in analytical chemistry and as a reaction medium for various organic syntheses. The compound's solvent properties differ notably from related saturated hydrocarbons like 3-ethyl-3-methylpentane and 2,2,3-trimethylbutane, offering specific advantages in selective dissolution processes. OYSI maintains reliable supply chains for cyclohexane, ensuring consistent availability for European industrial customers requiring this essential cyclic hydrocarbon solvent.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Asp. Tox. 1; STOT SE 3; Skin Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H304

May be fatal if swallowed and enters airways.

H336

May cause drowsiness or dizziness.

H315

Causes skin irritation.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Irritant

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1145
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameCyclohexan
Marine PollutantNo

Frequently Asked Questions

What is cyclohexane?

Cyclohexane is a saturated cyclic hydrocarbon with the molecular formula C6H12 and CAS number 110-82-7. It consists of six carbon atoms arranged in a ring structure with twelve hydrogen atoms. This colorless liquid has a molecular weight of 84.16 g/mol and belongs to the cycloalkane family. Cyclohexane is highly flammable and poses various health and environmental hazards, requiring careful handling in industrial applications.

What are the physicochemical properties of cyclohexane?

Cyclohexane is a colorless, volatile liquid with a characteristic sweet odor at room temperature. It has a boiling point of approximately 81°C and a melting point of 6.5°C. The compound is practically insoluble in water but miscible with most organic solvents including alcohols, ethers, and hydrocarbons. It has a density of about 0.78 g/cm³ and exhibits high vapor pressure, making it easily evaporable.

What is cyclohexane used for?

Cyclohexane is primarily used as a solvent in industrial processes and as an intermediate in chemical synthesis. It serves as a key raw material for producing nylon precursors, particularly adipic acid and caprolactam. The compound is also utilized in paint thinners, adhesives, and extraction processes. Additionally, cyclohexane finds applications in analytical chemistry as a non-polar solvent and in the rubber industry for various manufacturing processes.

How to handle cyclohexane safely?

Cyclohexane requires strict safety measures due to its flammable and toxic properties. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to prevent vapor accumulation. Eliminate all ignition sources as the substance is highly flammable (Flam. Liq. 2). Avoid skin contact as it may cause irritation (Skin Irrit. 2) and prevent inhalation to avoid respiratory effects.

How to store cyclohexane correctly?

Cyclohexane must be stored in tightly closed containers in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Keep containers in areas with appropriate fire suppression systems and ensure proper grounding to prevent static electricity buildup. Store away from incompatible materials such as strong oxidizing agents. Maintain storage temperatures below the boiling point and regularly inspect containers for leaks or damage to prevent vapor accumulation.

What to do in case of contact with cyclohexane?

Cyclohexane contact requires immediate first aid measures. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with plenty of water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. If ingested, do not induce vomiting due to aspiration toxicity risk and seek immediate medical attention.

How to dispose of cyclohexane appropriately?

Cyclohexane disposal must comply with local and national environmental regulations due to its aquatic toxicity classification. The substance should never be poured down drains or disposed of in regular waste. Contact licensed waste management companies for proper disposal through methods such as incineration at appropriate facilities or solvent recovery processes. Small quantities may be collected by specialized hazardous waste services, ensuring proper labeling and documentation throughout the disposal process.

How to transport cyclohexane?

Cyclohexane is classified as ADR Class 3 (flammable liquid), Packing Group II, requiring specific transport regulations. Containers must meet UN packaging standards and be properly labeled with appropriate hazard markings and UN identification numbers. Transport vehicles need proper ventilation and fire suppression equipment. Drivers must hold ADR certification for dangerous goods transport. Shipping documents must include proper shipping names, hazard classes, and emergency response information according to international transport regulations.

Is cyclohexane subject to particular regulations?

Cyclohexane is subject to various regulatory frameworks including REACH registration in Europe and CLP classification requirements. The substance is not currently listed as a Substance of Very High Concern (SVHC). It must be classified with appropriate GHS pictogrammes (GHS02, GHS08, GHS07, GHS09) and carry the danger signal word. Workplace exposure limits apply in most jurisdictions, and environmental discharge restrictions exist due to its aquatic toxicity classification.

Where to buy cyclohexane in Europe?

Cyclohexane is available through OYSI, a European distributor of technical chemicals serving industrial customers across the continent. OYSI provides cyclohexane in various packaging sizes suitable for different industrial applications. As a specialized chemical distributor, OYSI ensures proper documentation, regulatory compliance, and technical support for cyclohexane purchases. Contact OYSI directly for specific availability, technical specifications, and delivery options to your location within Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.