But-2-enoyl chloride

But-2-enoyl chloride is an organic chemical compound with the molecular formula C4H5ClO and CAS number 10487-71-5. This acyl chloride features an unsaturated four-carbon chain with a double bond between the second and third carbons, terminated by a highly reactive chlorocarbonyl functional group. With a molecular weight of 104.53 g/mol, it belongs to the family of α,β-unsaturated acyl chlorides, making it a valuable intermediate in organic synthesis.

But-2-enoyl chloride is typically a colorless to pale yellow liquid at room temperature with a pungent, acrid odor characteristic of acyl chlorides. The compound is highly reactive due to its acyl chloride functionality and readily hydrolyzes in the presence of moisture, releasing hydrogen chloride gas. It has limited solubility in water due to rapid hydrolysis but is soluble in organic solvents such as dichloromethane, chloroform, and aromatic hydrocarbons.

But-2-enoyl chloride serves primarily as a synthetic intermediate in pharmaceutical and fine chemical manufacturing. It is used for the preparation of amides, esters, and other derivatives through nucleophilic acyl substitution reactions. The compound finds applications in the synthesis of bioactive molecules, agrochemicals, and specialty chemicals. Its α,β-unsaturated structure makes it particularly valuable for creating compounds with specific stereochemical requirements in medicinal chemistry and materials science.

But-2-enoyl chloride requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and lab coats. Work should be conducted in a well-ventilated area or under a fume hood to avoid inhalation of vapors or hydrogen chloride gas released upon hydrolysis. Avoid contact with skin, eyes, and clothing. Use proper grounding techniques when transferring the material to prevent static discharge, and ensure all personnel are trained in emergency procedures.

But-2-enoyl chloride should be stored in tightly sealed containers made of compatible materials, away from moisture and humidity. Keep the compound in a cool, dry, well-ventilated area away from heat sources and incompatible substances such as alcohols, amines, and water. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures. Regular inspection of container integrity is essential due to the corrosive nature of the compound.

But-2-enoyl chloride contact requires immediate action. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult safety data sheets for specific guidance.

But-2-enoyl chloride disposal must comply with local and national hazardous waste regulations. The compound should be collected in appropriate containers and disposed of through licensed hazardous waste disposal facilities. Small quantities may be carefully hydrolyzed under controlled conditions to form the corresponding carboxylic acid, but this should only be performed by trained personnel with proper safety equipment. Never dispose of the compound down drains or in regular waste streams due to its reactive and potentially harmful nature.

But-2-enoyl chloride is classified under ADR Class 8 (Corrosive substances) with Packing Group II, indicating moderate danger level. Transportation requires appropriate UN-approved packaging designed for corrosive liquids, proper labeling with Class 8 hazard labels, and accompanying transport documentation. Vehicles must be equipped with appropriate emergency equipment and drivers should be trained in ADR requirements. Shipments must comply with quantity limitations and routing restrictions as specified in dangerous goods regulations.

But-2-enoyl chloride is subject to various chemical regulations including REACH registration requirements for manufacture or import in the European Union above certain tonnage thresholds. The compound is not currently listed as a Substance of Very High Concern (SVHC). However, it must comply with CLP regulation for classification, labeling, and packaging. Users should maintain safety data sheets, implement appropriate risk management measures, and ensure compliance with local occupational health and safety regulations.

But-2-enoyl chloride is available through OYSI, a specialized European distributor of technical chemicals serving various industries across the continent. OYSI provides high-quality chemical products with comprehensive technical support and regulatory compliance documentation. As an established chemical distributor, OYSI ensures proper handling, storage, and transportation of reactive compounds like but-2-enoyl chloride. Contact OYSI directly for availability, specifications, and delivery options tailored to your specific requirements and location within Europe.