2-(diethylamino)ethanol

C6H15NO

CAS100-37-8
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
100-37-8
EC Number
202-845-2
UN Number
2686
Index Number
603-048-00-6
PubChem CID
7497

Physical-chemical properties

Molecular Formula
C6H15NO
Molar Mass
117.19 g/mol
IUPAC Name
2-(diethylamino)ethanol

Chemical Identifiers

InChI
InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3
InChI Key
BFSVOASYOCHEOV-UHFFFAOYSA-N

Overview

2-(diethylamino)ethanol (CAS 100-37-8) is a tertiary amine alcohol compound characterized by its dual functionality as both an amine and alcohol group. This versatile chemical intermediate combines the properties of both amine and alcohol functional groups, making it valuable across multiple industrial applications. The compound appears as a colorless to pale yellow liquid with a characteristic amine odor and exhibits excellent solubility in water and most organic solvents due to its amphiphilic nature. From a safety perspective, 2-(diethylamino)ethanol requires careful handling as it is classified as a flammable liquid (Category 3) and presents acute toxicity risks through oral, dermal, and inhalation routes. The compound is particularly concerning due to its skin corrosive properties (Category 1B), necessitating appropriate personal protective equipment and engineering controls during handling. Its ADR classification as Class 8 (corrosive substance) reflects these hazardous characteristics and impacts transportation requirements. The dual functionality of 2-(diethylamino)ethanol makes it particularly useful in pharmaceutical synthesis as a building block for active pharmaceutical ingredients and intermediates. It serves as an important catalyst and intermediate in polyurethane foam production, where its amine group facilitates the polymerization process while the alcohol group can participate in chain extension reactions. Additionally, the compound finds application in corrosion inhibitor formulations for metalworking fluids and industrial cooling systems. Like its structural analog 2-(dimethylamino)ethanol, this compound demonstrates excellent catalytic properties in urethane chemistry, though with different reactivity profiles due to the larger ethyl substituents compared to methyl groups. OYSI offers 2-(diethylamino)ethanol to support various industrial applications across Europe, backed by comprehensive technical documentation and regulatory compliance support.

Safety & Classification

Danger
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2686
ADR Class8
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name2-Diethylaminoethanol
Marine PollutantNo

Frequently Asked Questions

What is 2-(diethylamino)ethanol?

2-(diethylamino)ethanol is an organic chemical compound with the molecular formula C6H15NO and CAS number 100-37-8. This tertiary amine alcohol has a molecular weight of 117.19 g/mol and belongs to the family of aminoalcohols. It is classified as a hazardous substance with corrosive properties to skin and moderate acute toxicity. The compound is also flammable and requires careful handling due to its multiple hazard classifications under the GHS system.

What are the physicochemical properties of 2-(diethylamino)ethanol?

2-(diethylamino)ethanol is typically a clear to pale yellow liquid at room temperature with a characteristic amine-like odor. As an aminoalcohol, it exhibits good solubility in water and polar organic solvents due to its hydroxyl and amino functional groups. The compound has both hydrophilic and hydrophobic characteristics, making it useful as a surfactant or intermediate. Its dual functionality allows it to participate in various chemical reactions typical of both alcohols and tertiary amines.

What is 2-(diethylamino)ethanol used for?

2-(diethylamino)ethanol serves as an important chemical intermediate in pharmaceutical synthesis, particularly in the production of local anesthetics like procaine and lidocaine derivatives. It is also used in the manufacture of corrosion inhibitors, textile auxiliaries, and as a catalyst in polyurethane foam production. Additionally, it finds applications in metalworking fluids, paint formulations, and as a neutralizing agent in various industrial processes where both amine and alcohol functionalities are required.

How to handle 2-(diethylamino)ethanol safely?

Safe handling of 2-(diethylamino)ethanol requires comprehensive personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its skin corrosive properties. Work must be conducted in well-ventilated areas or under fume extraction to prevent inhalation exposure. Avoid contact with skin, eyes, and clothing. Use non-sparking tools and equipment due to its flammable nature. Ensure proper grounding and bonding during transfer operations to prevent static electricity buildup.

How to store 2-(diethylamino)ethanol correctly?

2-(diethylamino)ethanol must be stored in a cool, dry, well-ventilated area away from heat sources, ignition sources, and direct sunlight. Use corrosion-resistant containers with tight-fitting lids to prevent vapor release and contamination. Store separately from strong acids, strong oxidizers, and incompatible materials. Maintain storage temperatures below the flash point and ensure compliance with local fire safety regulations. Secondary containment is recommended to prevent environmental contamination in case of spills.

What to do in case of contact with 2-(diethylamino)ethanol?

Immediate action is crucial due to the corrosive nature of 2-(diethylamino)ethanol. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. Seek immediate medical attention for all exposure routes, especially skin and eye contact, as serious burns may occur.

How to dispose of 2-(diethylamino)ethanol appropriately?

2-(diethylamino)ethanol must be disposed of in accordance with local, national, and international waste regulations as hazardous waste. The substance cannot be discharged to sewers or water bodies due to its corrosive and toxic properties. Professional hazardous waste disposal companies should handle the waste, typically through high-temperature incineration at licensed facilities. Empty containers must also be treated as hazardous waste. Consult local environmental authorities for specific disposal requirements and authorized waste treatment facilities.

How to transport 2-(diethylamino)ethanol?

2-(diethylamino)ethanol is classified under ADR as Class 8 (corrosive substances), Packing Group II, indicating it requires specific transport regulations. Packaging must meet UN specification requirements for corrosive liquids and be properly marked and labeled with appropriate hazard signs. Transport vehicles must carry appropriate emergency equipment and documentation. Drivers require ADR training certification for dangerous goods transport. Proper segregation from incompatible substances during transport is mandatory to ensure safety.

Is 2-(diethylamino)ethanol subject to specific regulations?

2-(diethylamino)ethanol is subject to multiple European regulations including REACH registration requirements for importers and manufacturers. Under CLP regulation, it must be classified and labeled according to its hazard profile including corrosive and acute toxicity classifications. The substance is not currently listed as SVHC under REACH. Industrial users must comply with occupational safety regulations, environmental discharge limits, and maintain safety data sheets. Transport is regulated under ADR/RID dangerous goods regulations as a Class 8 substance.

Where to buy 2-(diethylamino)ethanol in Europe?

2-(diethylamino)ethanol is available through OYSI, a specialized European distributor of industrial chemicals serving customers across the European market. OYSI provides technical-grade chemical products with proper documentation including safety data sheets and certificates of analysis. As an established chemical distributor, OYSI ensures compliance with European regulations including REACH and CLP requirements. Contact OYSI directly for specific product specifications, packaging options, and availability information to meet your industrial chemical requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.