Benzene-1,3-diol

C6H6O2

benzene-1,3-diol

CAS108-46-3
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
108-46-3
EC Number
203-585-2
UN Number
2876
Index Number
604-010-00-1
PubChem CID
5054

Physical-chemical properties

Molecular Formula
C6H6O2
Molar Mass
110.11 g/mol
IUPAC Name
benzene-1,3-diol

Chemical Identifiers

InChI
InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
InChI Key
GHMLBKRAJCXXBS-UHFFFAOYSA-N

Overview

Benzene-1,3-diol (CAS 108-46-3) is an organic dihydroxy compound with significant industrial applications and notable safety considerations. Also known by its common name resorcinol, this aromatic diol consists of a benzene ring with two hydroxyl groups positioned at the 1 and 3 carbons. With the molecular formula C6H6O2 and a molecular weight of 110.11 g/mol, benzene-1,3-diol presents as a white crystalline solid that readily dissolves in water and most organic solvents. The compound's chemical structure, featuring two phenolic hydroxyl groups in meta positions, confers unique reactivity patterns that make it valuable across multiple industrial sectors. From a safety perspective, benzene-1,3-diol requires careful handling due to its classification under several hazard categories. The substance carries a "Danger" signal word and displays GHS pictograms GHS07, GHS08, and GHS09, indicating acute toxicity, specific target organ toxicity, skin and eye irritation, skin sensitization, and aquatic toxicity concerns. Its ADR classification as Class 6.1 reflects its toxic properties during transportation. Proper personal protective equipment and adequate ventilation are essential when working with this chemical. Industrial applications of benzene-1,3-diol span diverse sectors, primarily in polymer chemistry where it serves as a key intermediate in rubber production and adhesive formulations. The pharmaceutical industry utilizes this compound in drug synthesis pathways, while the cosmetics sector incorporates it into hair dye formulations. Unlike structurally different compounds such as 4-[(4-aminophenyl)methyl]aniline, benzene-1,3-diol's phenolic nature makes it particularly suitable for condensation reactions and cross-linking applications. OYSI maintains reliable supplies of technical-grade benzene-1,3-diol to support European industrial requirements across multiple application areas.

Safety & Classification

Danger
Classification:

Acute Tox. 4; STOT SE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1B; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H370

Causes damage to organs.

H315

Causes skin irritation.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2876
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameResorcinol, fest
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,3-diol?

Benzene-1,3-diol is an organic chemical compound with the molecular formula C6H6O2 and CAS number 108-46-3. Also known as resorcinol, it consists of a benzene ring with two hydroxyl groups positioned at the 1 and 3 positions. With a molecular weight of 110.11 g/mol, this dihydroxybenzene derivative appears as white crystals or powder and is highly soluble in water and alcohol.

What are the physicochemical properties of benzene-1,3-diol?

Benzene-1,3-diol appears as white to light yellow crystalline powder or needles at room temperature. It has a melting point of approximately 110°C and is highly soluble in water, ethanol, and ether. The compound exhibits moderate volatility and has a characteristic phenolic odor. It readily undergoes oxidation and can form colored complexes with metal ions, making it useful in various analytical applications.

What is benzene-1,3-diol used for?

Benzene-1,3-diol is primarily used in the production of adhesives, particularly resorcinol-formaldehyde resins for wood bonding applications. It serves as an intermediate in pharmaceutical synthesis, rubber production, and dye manufacturing. The compound is also utilized in cosmetic formulations, hair dyes, antiseptic preparations, and as a chemical intermediate for various organic syntheses in the pharmaceutical and chemical industries.

How to handle benzene-1,3-diol safely?

Benzene-1,3-diol requires careful handling due to its classification as Acute Tox. 4, Skin Irrit. 2, and Skin Sens. 1B. Wear appropriate PPE including nitrile gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Avoid skin and eye contact, and prevent dust formation. Use non-sparking tools and ensure proper grounding to prevent static electricity buildup.

How to store benzene-1,3-diol correctly?

Benzene-1,3-diol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers away from incompatible materials such as strong oxidizing agents and strong bases. Store at temperatures below 25°C and protect from moisture to prevent degradation. Ensure storage areas are equipped with appropriate spill containment measures and emergency equipment.

What to do in case of contact with benzene-1,3-diol?

Benzene-1,3-diol contact requires immediate action due to its skin and eye irritation properties. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes and remove contact lenses if present. If inhaled, move to fresh air. Seek medical attention if symptoms persist or develop.

How to dispose of benzene-1,3-diol appropriately?

Benzene-1,3-diol disposal must comply with local and national hazardous waste regulations due to its classification as harmful to aquatic life. Contact licensed waste disposal companies for proper treatment and disposal. Small quantities can be treated through controlled incineration at authorized facilities. Never dispose of in regular waste streams, sewers, or waterways. Keep detailed disposal records as required by environmental regulations.

How to transport benzene-1,3-diol?

Benzene-1,3-diol is classified under ADR as Class 6.1 (toxic substances), Packing Group III for transportation purposes. It requires appropriate UN specification packaging with proper labeling including GHS07, GHS08, and GHS09 pictograms. Transport vehicles must carry appropriate documentation, emergency procedures, and safety equipment. Drivers require ADR training certification, and shipments must comply with quantity limitations and routing restrictions for dangerous goods.

Is benzene-1,3-diol subject to specific regulations?

Benzene-1,3-diol is regulated under REACH regulation in Europe and must comply with CLP classification requirements. While not currently listed as a SVHC (Substance of Very High Concern), it is subject to standard chemical safety reporting and supply chain communication requirements. Users must maintain safety data sheets, implement appropriate risk management measures, and ensure proper hazard communication throughout the supply chain according to CLP regulations.

Where to buy benzene-1,3-diol in Europe?

Benzene-1,3-diol is available through OYSI, a specialized European distributor of industrial chemicals. OYSI provides high-quality benzene-1,3-diol with complete documentation including safety data sheets, certificates of analysis, and regulatory compliance information. As a professional chemical distributor, OYSI ensures proper handling, storage, and transportation while offering technical support and regulatory guidance to customers across Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.