Quinoline

Quinoline is a heterocyclic aromatic organic compound with the molecular formula C9H7N and CAS number 91-22-5. It consists of a benzene ring fused to a pyridine ring, forming a bicyclic structure with a molecular weight of 129.16 g/mol. This nitrogen-containing compound appears as a colorless to pale yellow liquid with a characteristic odor and is classified as a hazardous substance due to its carcinogenic and mutagenic properties.

Quinoline is a colorless to pale yellow liquid at room temperature with a strong, unpleasant odor reminiscent of coal tar. It has a boiling point of 237°C and is slightly soluble in water but readily soluble in most organic solvents including alcohol, ether, and benzene. The compound is hygroscopic and can darken upon exposure to light and air, forming brownish discoloration over time.

Quinoline serves as an important intermediate in pharmaceutical manufacturing, particularly in the synthesis of antimalarial drugs, antibiotics, and other therapeutic compounds. It is also used in the production of dyes, pigments, and specialty chemicals. Additionally, quinoline finds applications in the manufacture of rubber accelerators, corrosion inhibitors, and as a solvent for resins and terpenes in various industrial processes.

Quinoline must be handled with extreme caution due to its carcinogenic and mutagenic properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact, and ensure proper grounding when transferring the material to prevent static electricity buildup.

Quinoline should be stored in tightly sealed containers made of compatible materials in a cool, dry, well-ventilated area away from heat sources, ignition sources, and direct sunlight. Keep containers away from incompatible materials such as strong oxidizing agents and acids. Storage areas should be equipped with appropriate containment measures and maintained at temperatures below 25°C to prevent degradation and minimize vapor formation.

Quinoline exposure requires immediate first aid measures. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention in all cases.

Quinoline waste must be disposed of as hazardous waste according to local and national regulations due to its carcinogenic properties and environmental hazards. The material should never be poured down drains or disposed of with regular waste. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small quantities may require incineration at high temperatures in specialized facilities equipped with appropriate emission controls.

Quinoline is classified under ADR as Class 6.1 (Toxic substances), Packing Group III for transportation purposes. It must be transported in UN-approved packaging with proper labeling including the toxic hazard diamond and appropriate shipping documentation. Vehicles must carry emergency response information and drivers require ADR certification. The substance should be secured to prevent movement and protected from temperature extremes during transit.

Quinoline is subject to strict regulations under REACH and CLP due to its classification as carcinogenic (Category 1B) and mutagenic (Category 2). It requires safety data sheets, exposure scenarios, and registration for commercial use. The substance may be subject to authorization requirements and use restrictions depending on the application. Employers must implement comprehensive risk management measures and health surveillance programs for workers potentially exposed to quinoline.

Quinoline is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI can provide quinoline with appropriate documentation including safety data sheets, certificates of analysis, and regulatory compliance information. Due to the hazardous nature of quinoline, purchases are typically restricted to qualified industrial users with proper handling facilities and regulatory permits for its intended applications.