5-methyl-1H-pyrazole

5-methyl-1H-pyrazole is an organic chemical compound with the molecular formula C4H6N2 and CAS number 1453-58-3. It belongs to the pyrazole family, which are five-membered heterocyclic compounds containing two nitrogen atoms. With a molecular weight of 82.1 g/mol, this substance is classified as hazardous with multiple danger classes including reproductive toxicity, acute toxicity, and corrosive properties requiring careful handling in industrial applications.

5-methyl-1H-pyrazole is a small organic molecule with molecular formula C4H6N2 and molecular weight of 82.1 g/mol. As a pyrazole derivative, it typically exists as a crystalline solid at room temperature with characteristic nitrogen-containing heterocyclic structure. The compound exhibits basic properties due to its nitrogen atoms and shows solubility in polar solvents. Its specific physical properties like melting point and solubility should be verified from technical datasheets for precise applications.

5-methyl-1H-pyrazole serves as an important intermediate in pharmaceutical and agrochemical synthesis. It is commonly used in the production of active pharmaceutical ingredients, particularly in the development of anti-inflammatory and antimicrobial compounds. The substance also finds applications in the synthesis of pesticides and herbicides, as well as in research and development for new chemical entities. Its pyrazole structure makes it valuable for creating complex molecular frameworks in organic synthesis.

5-methyl-1H-pyrazole requires strict safety measures due to its corrosive and toxic properties. Workers must wear full personal protective equipment including chemical-resistant gloves, safety goggles, face shields, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Due to its reproductive toxicity (Category 1B) and skin corrosive properties, minimize direct contact and ensure emergency shower facilities are readily available during handling operations.

5-methyl-1H-pyrazole must be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. As a Class 8 corrosive substance, it should be segregated from oxidizing agents, strong bases, and organic materials. Storage areas must be equipped with appropriate spill containment measures and maintained at stable temperatures. Access should be restricted to trained personnel, and containers should be regularly inspected for signs of corrosion or leakage.

Immediate action is critical due to the corrosive nature of 5-methyl-1H-pyrazole. For skin contact, remove contaminated clothing and rinse affected area with copious amounts of water for at least 15 minutes. In case of eye contact, flush immediately with water for 15-20 minutes and seek medical attention. If inhaled, move victim to fresh air and provide respiratory support if needed. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult safety data sheets for specific emergency procedures.

5-methyl-1H-pyrazole must be disposed of as hazardous waste through licensed waste management companies in accordance with local and EU regulations. The substance cannot be discharged into sewers, waterways, or regular waste streams due to its toxic and corrosive properties. Waste containers should be properly labeled and stored separately from other waste types. Incineration at authorized high-temperature facilities is typically the preferred disposal method, following all applicable waste codes and transportation requirements for hazardous materials.

5-methyl-1H-pyrazole is classified as ADR Class 8 (corrosive substances), Packing Group II, requiring specialized transportation procedures. Packages must meet UN specification standards for corrosive liquids and be properly labeled with appropriate hazard labels and markings. Transport vehicles must carry emergency response information and appropriate safety equipment. Drivers need ADR certification for dangerous goods transport, and shipments must comply with routing restrictions and quantity limitations as specified in ADR regulations for Class 8 substances.

5-methyl-1H-pyrazole is subject to comprehensive EU chemical regulations including REACH registration requirements and CLP classification as a Category 1B reproductive toxicant. While not currently listed as a Substance of Very High Concern (SVHC), its hazardous properties require strict compliance with occupational exposure limits and workplace safety regulations. Users must maintain safety data sheets, implement appropriate risk management measures, and may need authorization for certain uses depending on application and exposure scenarios under REACH.

5-methyl-1H-pyrazole is available through OYSI, a specialized European distributor of technical chemical products. OYSI provides this substance to qualified industrial customers with proper handling capabilities and regulatory compliance. Due to the hazardous nature of this compound, purchases require verification of appropriate safety measures, trained personnel, and legitimate industrial use. Contact OYSI directly for availability, specifications, and technical support to ensure proper handling and regulatory compliance for your specific application requirements.