5-methyl-1H-pyrazole

5-methyl-1H-pyrazole is an organic heterocyclic compound with the molecular formula C4H6N2 and CAS number 1453-58-3. This pyrazole derivative has a molecular weight of 82.1 g/mol and contains a five-membered ring with two nitrogen atoms and a methyl substituent at position 5. It is classified as a hazardous substance with multiple danger classes including reproductive toxicity, acute toxicity, and corrosive properties.

5-methyl-1H-pyrazole is a heterocyclic compound that typically appears as a crystalline solid at room temperature. As a pyrazole derivative, it exhibits basic properties due to its nitrogen-containing ring structure. The compound has a molecular weight of 82.1 g/mol and contains two nitrogen atoms in its five-membered ring. Its physicochemical properties make it suitable for various chemical synthesis applications while requiring careful handling due to its hazardous classification.

5-methyl-1H-pyrazole is primarily used as a chemical intermediate in pharmaceutical synthesis and fine chemical manufacturing. It serves as a building block for the production of various bioactive compounds and pharmaceutical ingredients. The compound is also utilized in research and development applications, particularly in medicinal chemistry for the synthesis of pyrazole-containing molecules. Its reactive nature makes it valuable for creating more complex molecular structures in specialized chemical processes.

5-methyl-1H-pyrazole requires strict safety measures due to its corrosive and toxic properties. Personnel must wear full personal protective equipment including chemical-resistant gloves, safety goggles, face protection, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Avoid skin and eye contact completely, as the substance is classified as corrosive (Skin Corr. 1, Eye Dam. 1) and poses reproductive toxicity risks.

5-methyl-1H-pyrazole must be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Storage areas should be equipped with appropriate containment measures and emergency equipment. Keep containers upright and properly labeled according to GHS requirements. Access should be restricted to trained personnel only, and storage facilities must comply with local regulations for corrosive and toxic substances. Regular container inspection is essential to prevent leaks.

Immediate action is critical due to the corrosive nature of 5-methyl-1H-pyrazole. For skin contact, immediately remove contaminated clothing and flush affected areas with copious amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with water for at least 15 minutes and seek immediate medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician in any exposure case.

5-methyl-1H-pyrazole must be disposed of through licensed hazardous waste disposal facilities in accordance with local, national, and EU regulations. The substance cannot be disposed of in regular waste streams due to its toxic and corrosive properties. Waste containers must be properly labeled and segregated from other waste types. Collection, transport, and disposal must be performed by certified waste management companies. Documentation of disposal is required for regulatory compliance and traceability purposes.

5-methyl-1H-pyrazole is classified as ADR Class 8 (corrosive substances) Packing Group II, requiring specific transport regulations compliance. Packages must meet UN specification requirements and be properly labeled with appropriate hazard labels and markings. Transport vehicles must carry appropriate emergency equipment and documentation. Drivers require ADR training certification for dangerous goods transport. Shipping documents must include proper shipping names, hazard classes, and emergency response information according to international dangerous goods regulations.

5-methyl-1H-pyrazole is subject to comprehensive chemical safety regulations under EU REACH and CLP regulations. It must be classified and labeled according to its hazard classes (Repr. 1B, Acute Tox. 4, STOT RE 2, Skin Corr. 1, Eye Dam. 1). While not currently listed as a Substance of Very High Concern (SVHC), it requires safety data sheets and risk assessments. Transportation is regulated under ADR as a Class 8 corrosive substance, and workplace exposure limits may apply under occupational safety regulations.

5-methyl-1H-pyrazole is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support across European markets. As a professional chemical distributor, OYSI ensures proper packaging, labeling, and transport arrangements according to ADR and other applicable regulations. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements.