Furan-2,5-dione

C4H2O3

furan-2,5-dione

CAS108-31-6
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
108-31-6
EC Number
203-571-6
UN Number
2215
Index Number
607-096-00-9
PubChem CID
7923

Physical-chemical properties

Molecular Formula
C4H2O3
Molar Mass
98.06 g/mol
IUPAC Name
furan-2,5-dione

Chemical Identifiers

InChI
InChI=1S/C4H2O3/c5-3-1-2-4(6)7-3/h1-2H
InChI Key
FPYJFEHAWHCUMM-UHFFFAOYSA-N

Overview

Furan-2,5-dione (CAS 108-31-6) is a cyclic anhydride compound with high reactivity and corrosive properties. This organic compound, also known by its IUPAC name furan-2,5-dione, represents a significant chemical intermediate in various industrial processes. With the molecular formula C4H2O3 and a molecular weight of 98.06 g/mol, this cyclic anhydride exhibits characteristic properties that make it valuable for specialized chemical applications while requiring careful handling protocols. The compound presents considerable safety considerations, classified under multiple hazard categories including acute toxicity, skin corrosion, eye damage, and respiratory sensitization. Its classification as Skin Corr. 1B and Eye Dam. 1 indicates severe corrosive potential, while the Resp. Sens. 1 and Skin Sens. 1A classifications highlight its sensitizing properties. The ADR Class 8 designation confirms its corrosive nature for transportation purposes, requiring appropriate packaging and handling procedures. Furan-2,5-dione finds primary applications in polymer chemistry as a crosslinking agent and in the synthesis of specialized resins. The chemical industry utilizes this compound for manufacturing certain pharmaceutical intermediates and in advanced materials development. Its reactivity with amines, similar to interactions seen with compounds like ethane-1,2-diamine, makes it particularly useful in creating specific polymer networks and chemical modifications. Industrial users appreciate furan-2,5-dione for its efficiency in creating durable chemical bonds, particularly in applications requiring enhanced thermal stability and chemical resistance. The compound's ability to undergo rapid reactions with nucleophiles makes it valuable for time-sensitive manufacturing processes. OYSI maintains reliable supply chains for furan-2,5-dione, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Acute Tox. 4; STOT RE 1; Skin Corr. 1B; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1A

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H372

Causes damage to organs through prolonged or repeated exposure.

H314

Causes severe skin burns and eye damage.

H318

Causes serious eye damage.

H334

May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H317

May cause an allergic skin reaction.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2215
ADR Class8
Packing GroupIII
Tunnel CodeE
Proper Shipping NameMaleinsäureanhydrid, geschmolzen
Marine PollutantNo

Frequently Asked Questions

What is furan-2,5-dione?

Furan-2,5-dione is an organic chemical compound with the molecular formula C4H2O3 and CAS number 108-31-6. Also known as maleic anhydride, it is a cyclic anhydride derived from maleic acid. This compound has a molecular weight of 98.06 g/mol and is classified as a hazardous substance with multiple danger classifications including acute toxicity, skin corrosion, respiratory sensitization, and specific target organ toxicity after repeated exposure.

What are the physicochemical properties of furan-2,5-dione?

Furan-2,5-dione typically appears as white crystalline needles or pellets at room temperature. It has a sharp, acrid odor and sublimes readily, producing irritating vapors. The compound is highly soluble in water, reacting to form maleic acid, and is also soluble in acetone, chloroform, and benzene. It has a melting point around 52-56°C and readily hydrolyzes in the presence of moisture.

What is furan-2,5-dione used for?

Furan-2,5-dione serves as an important intermediate in chemical manufacturing, particularly in the production of unsaturated polyester resins, alkyd resins, and copolymers. It is widely used in the synthesis of pharmaceuticals, agricultural chemicals, and food additives. The compound also finds applications in the manufacture of fumaric acid, malic acid, and various polymer additives for industrial processes.

How to handle furan-2,5-dione safely?

Furan-2,5-dione requires careful handling due to its corrosive and sensitizing properties. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work in well-ventilated areas or under fume extraction systems to prevent inhalation exposure. Avoid skin and eye contact completely, and ensure emergency shower and eyewash facilities are readily accessible during handling operations.

How to store furan-2,5-dione correctly?

Furan-2,5-dione must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from moisture and heat sources. Keep containers away from incompatible materials such as strong bases, alcohols, and oxidizing agents. Store in original packaging with proper labeling and ensure storage areas are equipped with appropriate spill containment measures and fire suppression systems.

What to do in case of contact with furan-2,5-dione?

Furan-2,5-dione contact requires immediate action due to its corrosive nature. For skin contact, immediately flush with large amounts of water for at least 15 minutes and remove contaminated clothing. In case of eye contact, rinse immediately with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. Always seek medical advice after any significant exposure.

How to dispose of furan-2,5-dione appropriately?

Furan-2,5-dione disposal must comply with local and national hazardous waste regulations. The substance should be treated as corrosive hazardous waste and disposed of through licensed hazardous waste contractors. Never discharge into drains, water courses, or onto the ground. Small quantities may be neutralized carefully under controlled conditions by trained personnel before disposal, following approved procedures and local environmental regulations.

How to transport furan-2,5-dione?

Furan-2,5-dione is classified as ADR Class 8 (Corrosive substances), Packing Group III for transport purposes. It must be packaged in approved UN specification containers with proper hazard labels and documentation. Transport vehicles must carry appropriate emergency equipment and drivers require ADR training. Shipping papers must include proper shipping names, hazard classes, and emergency response information.

Is furan-2,5-dione subject to specific regulations?

Furan-2,5-dione is subject to various European regulations including REACH registration requirements and CLP classification as a hazardous substance. It is not currently listed as a Substance of Very High Concern (SVHC). Companies must comply with occupational exposure limits, safety data sheet requirements, and workplace health and safety regulations. Industrial users may need specific permits depending on quantities and applications.

Where to buy furan-2,5-dione in Europe?

Furan-2,5-dione is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides high-quality furan-2,5-dione with complete regulatory documentation including safety data sheets and certificates of analysis. As an established chemical distributor, OYSI ensures reliable supply chains and regulatory compliance for industrial customers across Europe requiring this specialized chemical intermediate.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.