2-methoxyacetic acid

C3H6O3

CAS625-45-6
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
625-45-6
EC Number
210-894-6
UN Number
3265
Index Number
607-312-00-1
PubChem CID
12251

Physical-chemical properties

Molecular Formula
C3H6O3
Molar Mass
90.08 g/mol
IUPAC Name
2-methoxyacetic acid

Chemical Identifiers

InChI
InChI=1S/C3H6O3/c1-6-2-3(4)5/h2H2,1H3,(H,4,5)
InChI Key
RMIODHQZRUFFFF-UHFFFAOYSA-N

Overview

2-methoxyacetic acid (CAS 625-45-6) is a methoxy-substituted carboxylic acid with corrosive properties and significant reproductive toxicity concerns. This organic compound represents a specialized chemical intermediate characterized by its unique molecular structure combining methoxy and carboxylic acid functional groups. With the molecular formula C3H6O3 and a molecular weight of 90.08 g/mol, 2-methoxyacetic acid exhibits distinct chemical reactivity patterns that make it valuable in various industrial synthesis processes. The compound's EC number 210-894-6 identifies it within the European chemical inventory system. The substance presents significant safety considerations, classified under multiple hazard categories including reproductive toxicity category 1B, acute toxicity category 4, and skin corrosion category 1B. These classifications necessitate stringent handling protocols and appropriate personal protective equipment during industrial use. The GHS pictograms GHS08, GHS07, and GHS05 clearly communicate the health hazard, harmful, and corrosive nature of this chemical. Transportation falls under ADR class 8, reflecting its corrosive properties. Industrial applications of 2-methoxyacetic acid primarily focus on chemical synthesis and pharmaceutical intermediates, where its methoxy functionality provides specific reactivity profiles. The compound serves in specialized organic synthesis routes and research applications requiring precise chemical modifications. Unlike simpler compounds such as ethane-1,2-diamine or cyclohexanamine, 2-methoxyacetic acid offers unique synthetic pathways due to its dual functional group arrangement. OYSI maintains availability of 2-methoxyacetic acid through our European distribution network, ensuring reliable supply chains for qualified industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Repr. 1B; Acute Tox. 4 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3265
ADR Class8
Packing GroupI
Tunnel CodeE
Proper Shipping NameMethoxyessigsäure
Marine PollutantNo

Frequently Asked Questions

What is 2-methoxyacetic acid?

2-methoxyacetic acid is an organic compound with the molecular formula C3H6O3 and CAS number 625-45-6. This chemical substance has a molecular weight of 90.08 g/mol and belongs to the carboxylic acid family. It is classified as a highly hazardous substance with reproductive toxicity, acute toxicity, and corrosive properties, requiring careful handling and specialized safety measures in industrial applications.

What are the physicochemical properties of 2-methoxyacetic acid?

2-methoxyacetic acid is a liquid organic compound at room temperature with corrosive properties. As a carboxylic acid derivative containing a methoxy group, it typically exhibits good water solubility due to its polar functional groups. The substance has a molecular weight of 90.08 g/mol and contains both acidic and ether functionalities, making it reactive under various conditions.

What is 2-methoxyacetic acid used for?

2-methoxyacetic acid serves as an intermediate in organic synthesis and pharmaceutical manufacturing. It is utilized in the production of specialized chemicals, research applications, and as a building block for more complex molecular structures. Due to its reproductive toxicity classification, its use is strictly regulated and limited to professional industrial applications with appropriate safety controls and expertise.

How to handle 2-methoxyacetic acid safely?

2-methoxyacetic acid requires maximum protection due to its Repr. 1B, Acute Tox. 4, and Skin Corr. 1B classifications. Essential PPE includes chemical-resistant gloves, protective clothing, eye protection, and respiratory protection. Work must be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion. Only trained personnel should handle this substance following strict safety protocols.

How to store 2-methoxyacetic acid correctly?

2-methoxyacetic acid must be stored in a cool, dry, well-ventilated area away from incompatible materials. Use corrosion-resistant containers with tight seals to prevent leakage and vapor release. Storage areas should be restricted to authorized personnel only due to the substance's reproductive toxicity. Maintain temperatures within specified ranges and ensure proper containment systems are in place for spill control.

What to do in case of contact with 2-methoxyacetic acid?

Immediate action is crucial due to the corrosive and toxic nature of 2-methoxyacetic acid. For skin contact, remove contaminated clothing and flush with plenty of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes. If inhaled, move to fresh air. Seek immediate medical attention in all cases of exposure, providing the safety data sheet to medical personnel.

How to dispose of 2-methoxyacetic acid properly?

2-methoxyacetic acid disposal must comply with local and European hazardous waste regulations due to its toxic and corrosive properties. The substance cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment. Contact licensed waste disposal companies for proper collection and treatment. Never pour down drains or release into the environment. Maintain disposal records as required by regulations.

How to transport 2-methoxyacetic acid?

2-methoxyacetic acid is classified as ADR Class 8 (corrosive substances), Packing Group I, indicating high danger level. Transportation requires UN-approved packaging, proper labeling with GHS pictograms (GHS05, GHS07, GHS08), and adherence to dangerous goods regulations. Only certified carriers can transport this substance, and proper documentation including transport documents and emergency response information must accompany shipments.

Is 2-methoxyacetic acid subject to specific regulations?

2-methoxyacetic acid is subject to strict European regulations under REACH and CLP due to its hazardous properties. The substance requires registration, proper classification labeling, and safety data sheets. Its Repr. 1B classification may trigger additional restrictions on use and marketing. Companies handling this chemical must comply with occupational exposure limits, risk assessment requirements, and reporting obligations under relevant chemical legislation.

Where to buy 2-methoxyacetic acid in Europe?

2-methoxyacetic acid is available through specialized chemical distributors in Europe, including OYSI, which supplies high-quality chemical products to industrial customers. Due to the substance's hazardous classification, purchases are typically restricted to qualified industrial users with appropriate handling capabilities. Suppliers must provide proper documentation, safety data sheets, and ensure compliance with transportation and handling regulations for this controlled substance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.