4-methylaniline;sulfuric acid

C7H11NO4S

CAS540-25-0
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
540-25-0
EC Number
208-741-3
UN Number
2811
Index Number
612-160-00-4
PubChem CID
6452932

Physical-chemical properties

Molecular Formula
C7H11NO4S
Molar Mass
205.23 g/mol
IUPAC Name
4-methylaniline;sulfuric acid

Chemical Identifiers

InChI
InChI=1S/C7H9N.H2O4S/c1-6-2-4-7(8)5-3-6;1-5(2,3)4/h2-5H,8H2,1H3;(H2,1,2,3,4)
InChI Key
JWDHUQFIBCVYRH-UHFFFAOYSA-N

Overview

4-methylaniline;sulfuric acid (CAS 540-25-0) is an aromatic amine sulfate salt with significant carcinogenic properties and high acute toxicity. This chemical compound represents the sulfuric acid salt form of 4-methylaniline, also known as para-toluidine sulfate. With a molecular formula of C7H11NO4S and molecular weight of 205.23 g/mol, this substance combines the aromatic amine structure of 4-methylaniline with sulfuric acid, resulting in enhanced stability and modified solubility characteristics compared to the free base form. The compound belongs to the family of substituted anilines, sharing structural similarities with related compounds such as N-methylaniline, though it exhibits distinct toxicological and chemical properties. The substance presents significant safety concerns, classified as a Category 2 carcinogen with multiple acute toxicity classifications across oral, dermal, and inhalation routes. The presence of GHS08, GHS06, and GHS09 pictograms indicates health hazards, acute toxicity, and environmental dangers respectively. Additional hazard classifications include eye irritation, skin sensitization, and acute aquatic toxicity, requiring careful handling protocols and appropriate personal protective equipment. The ADR classification of 6.1 designates it as a toxic substance for transportation purposes. Industrial applications typically involve its use as an intermediate in organic synthesis, particularly in the production of dyes and pigments where the sulfate salt form provides improved handling characteristics. The compound also finds application in pharmaceutical intermediates and specialty chemical manufacturing, where its enhanced stability compared to free anilines proves advantageous. OYSI maintains availability of 4-methylaniline;sulfuric acid for qualified industrial customers requiring this specialized aromatic amine derivative.

Safety & Classification

Danger
Classification:

Carc. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name4-Toluidinsulfat (1:1)
Marine PollutantNo

Frequently Asked Questions

What is 4-methylaniline;sulfuric acid?

4-methylaniline;sulfuric acid is a chemical compound with CAS number 540-25-0 and molecular formula C7H11NO4S. This substance is the sulfate salt form of 4-methylaniline (para-toluidine), created by combining the aromatic amine with sulfuric acid. It has a molecular weight of 205.23 g/mol and is classified as a carcinogenic substance (Category 2) with multiple acute toxicity hazards. The compound presents significant health and environmental risks requiring careful handling procedures.

What are the physicochemical properties of 4-methylaniline;sulfuric acid?

4-methylaniline;sulfuric acid is a solid compound with molecular formula C7H11NO4S and molecular weight 205.23 g/mol. As a sulfate salt of an aromatic amine, it typically appears as crystalline solid that is water-soluble due to the sulfuric acid component. The compound's properties are influenced by both the organic amine portion and the inorganic acid, making it more stable and less volatile than the free base form while maintaining the chemical reactivity of the aromatic amine group.

What is 4-methylaniline;sulfuric acid used for?

4-methylaniline;sulfuric acid is primarily used as an intermediate in the production of dyes, pigments, and other organic compounds. The sulfate form provides better stability and handling characteristics compared to the free amine. It serves as a precursor for manufacturing various azo dyes, pharmaceuticals, and specialty chemicals. Due to its carcinogenic classification, its use is strictly regulated and limited to industrial applications with appropriate safety controls and professional handling requirements.

How to handle 4-methylaniline;sulfuric acid safely?

4-methylaniline;sulfuric acid requires strict safety protocols due to its Carc. 2 and Acute Tox. 3 classifications. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Skin contact must be avoided as the substance is a skin sensitizer. All handling procedures should follow occupational exposure limits and proper training is essential for workers dealing with this hazardous material.

How to store 4-methylaniline;sulfuric acid correctly?

4-methylaniline;sulfuric acid must be stored in a cool, dry, well-ventilated area away from incompatible materials. Containers should be tightly sealed and properly labeled with hazard information. Storage areas should be equipped with appropriate containment systems and restricted access due to the carcinogenic nature of the compound. The substance should be kept away from oxidizing agents, strong bases, and heat sources. Regular inspection of storage containers and implementation of inventory control measures are essential for safe storage.

What to do in case of contact with 4-methylaniline;sulfuric acid?

Immediate action is required for any contact with 4-methylaniline;sulfuric acid. For skin contact, remove contaminated clothing and flush the affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse immediately with water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and provide oxygen if breathing is difficult. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure incident.

How to dispose of 4-methylaniline;sulfuric acid appropriately?

4-methylaniline;sulfuric acid disposal must comply with local, national, and EU waste regulations as hazardous chemical waste. The substance cannot be disposed of in regular waste streams due to its carcinogenic and toxic properties. It requires treatment at authorized hazardous waste facilities with appropriate destruction methods such as high-temperature incineration. Waste containers must be properly labeled and documented. Generators must use licensed waste disposal companies and maintain disposal records as required by environmental regulations.

How to transport 4-methylaniline;sulfuric acid?

4-methylaniline;sulfuric acid is classified under ADR as Class 6.1 (toxic substances), Packing Group II. Transportation requires appropriate UN-certified packaging and hazard labeling including toxic substance markings. Vehicles must carry proper documentation including transport documents and emergency response information. Drivers need ADR training certification for dangerous goods transport. The substance must be segregated from incompatible materials during transport and emergency equipment must be available according to ADR regulations.

Is 4-methylaniline;sulfuric acid subject to specific regulations?

4-methylaniline;sulfuric acid is subject to extensive EU regulations including REACH registration requirements and CLP classification as Carc. 2. The substance falls under occupational exposure limits and requires risk assessments under workplace safety directives. As a carcinogenic substance, it may be subject to authorization procedures and use restrictions. Companies must maintain safety data sheets, implement exposure control measures, and comply with notification requirements. Additional national regulations may apply depending on the specific use and quantities handled.

Where to buy 4-methylaniline;sulfuric acid in Europe?

4-methylaniline;sulfuric acid is available through OYSI, a specialized European distributor of technical chemicals. As a regulated carcinogenic substance, purchases are restricted to qualified industrial users with appropriate safety infrastructure and regulatory compliance. OYSI provides comprehensive documentation including safety data sheets, certificates of analysis, and regulatory support. Due to the hazardous nature of this compound, procurement requires verification of end-use applications and compliance with REACH and other applicable European chemical regulations.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.