4-methylaniline;sulfuric acid

C7H11NO4S

CAS540-25-0
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
540-25-0
EC Number
208-741-3
UN Number
2811
Index Number
612-160-00-4
PubChem CID
6452932

Physical-chemical properties

Molecular Formula
C7H11NO4S
Molar Mass
205.23 g/mol
IUPAC Name
4-methylaniline;sulfuric acid

Chemical Identifiers

InChI
InChI=1S/C7H9N.H2O4S/c1-6-2-4-7(8)5-3-6;1-5(2,3)4/h2-5H,8H2,1H3;(H2,1,2,3,4)
InChI Key
JWDHUQFIBCVYRH-UHFFFAOYSA-N

Overview

4-methylaniline;sulfuric acid (CAS 540-25-0) is an aromatic amine sulfate salt compound with significant industrial applications and notable toxicological properties. This chemical substance represents a sulfate salt derivative of p-toluidine (4-methylaniline), formed through the reaction of the aromatic amine with sulfuric acid. The compound exhibits a molecular formula of C7H11NO4S with a molecular weight of 205.23 g/mol, classified under EC number 208-741-3. As an aromatic amine derivative, it belongs to a chemical family that includes related substances such as N-methylaniline and phenylhydrazine, sharing similar structural characteristics and industrial relevance. The substance presents significant safety considerations, classified as a Category 2 carcinogen with acute toxicity properties across multiple exposure routes. Safety protocols require careful handling due to its classification under GHS pictograms including health hazard (GHS08), acute toxicity (GHS06), and environmental hazard (GHS09) symbols. The compound carries a "Danger" signal word and falls under ADR Class 6.1 for transportation purposes, indicating its toxic nature. Additional hazard classifications include eye irritation, skin sensitization, and acute aquatic toxicity, necessitating comprehensive risk management measures. Industrial applications typically involve its use as a chemical intermediate in organic synthesis processes, particularly in the production of dyes and pigments where aromatic amine compounds serve as essential building blocks. The substance also finds application in pharmaceutical intermediates and specialized chemical manufacturing processes requiring aromatic amine derivatives. OYSI maintains availability of 4-methylaniline;sulfuric acid for qualified industrial customers, ensuring compliance with European chemical regulations and safety standards for professional applications.

Safety & Classification

Danger
Classification:

Carc. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name4-Toluidinsulfat (1:1)
Marine PollutantNo

Frequently Asked Questions

What is 4-methylaniline;sulfuric acid?

4-methylaniline;sulfuric acid is the sulfate salt of 4-methylaniline (p-toluidine), with CAS number 540-25-0 and molecular formula C7H11NO4S. This aromatic amine compound has a molecular weight of 205.23 g/mol and is classified as a carcinogenic substance (Category 2) under CLP regulation. It presents significant health hazards including acute toxicity and potential cancer risks, requiring careful handling in industrial applications.

What are the physicochemical properties of 4-methylaniline;sulfuric acid?

4-methylaniline;sulfuric acid is a solid crystalline compound at room temperature, typically appearing as white to off-white crystals. As a sulfate salt of an aromatic amine, it exhibits good water solubility due to its ionic nature. The compound has a molecular weight of 205.23 g/mol and contains both aromatic and ionic functional groups, making it stable under normal conditions but requiring protection from light and moisture.

What is 4-methylaniline;sulfuric acid used for?

4-methylaniline;sulfuric acid is primarily used as an intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. It serves as a precursor in the production of various aromatic compounds and can be employed in analytical chemistry applications. Due to its carcinogenic classification, its use is restricted to professional industrial settings with appropriate safety measures and is not intended for consumer applications.

How to handle 4-methylaniline;sulfuric acid safely?

4-methylaniline;sulfuric acid requires strict safety protocols due to its carcinogenic and toxic properties. Personal protective equipment must include nitrile gloves, safety goggles, and respiratory protection when handling. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion. Emergency eyewash stations and safety showers should be readily accessible during handling operations.

How to store 4-methylaniline;sulfuric acid correctly?

4-methylaniline;sulfuric acid should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight. Storage areas must be secured and accessible only to trained personnel due to its carcinogenic classification. Keep away from incompatible materials such as strong oxidizers and bases. Containers should be properly labeled with hazard warnings and stored in secondary containment systems.

What to do in case of contact with 4-methylaniline;sulfuric acid?

In case of skin contact with 4-methylaniline;sulfuric acid, immediately remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush with clean water for 15 minutes and seek immediate medical attention. If inhaled, move to fresh air and seek medical care. For ingestion, do not induce vomiting and obtain immediate medical assistance.

How to dispose of 4-methylaniline;sulfuric acid appropriately?

4-methylaniline;sulfuric acid must be disposed of as hazardous chemical waste through licensed waste management companies. Due to its carcinogenic classification and aquatic toxicity, it cannot be discharged into sewers or the environment. Containers should be properly labeled and segregated according to local and European waste regulations. Disposal must comply with REACH and national hazardous waste legislation requirements.

How to transport 4-methylaniline;sulfuric acid?

4-methylaniline;sulfuric acid is classified under ADR Class 6.1 (Toxic substances), Packing Group II, indicating moderate toxicity requiring special transport precautions. Packages must bear appropriate hazard labels including GHS08, GHS06, and GHS09 pictograms with 'Danger' signal word. Transportation requires proper documentation, approved packaging, and compliance with dangerous goods regulations for road, rail, and maritime transport within Europe.

Is 4-methylaniline;sulfuric acid subject to specific regulations?

4-methylaniline;sulfuric acid is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification as Carcinogenic Category 2. While not currently listed as an SVHC substance, its carcinogenic properties may require authorization for certain uses. Users must comply with occupational exposure limits, worker protection measures, and environmental discharge restrictions under various EU directives and national legislation.

Where to buy 4-methylaniline;sulfuric acid in Europe?

4-methylaniline;sulfuric acid can be purchased through OYSI, a European distributor specializing in technical chemicals for industrial applications. As a restricted carcinogenic substance, purchase is limited to qualified industrial users with appropriate handling capabilities and safety infrastructure. Buyers must demonstrate legitimate industrial use and comply with regulatory requirements for procurement, handling, and use of carcinogenic substances.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.