Benzene-1,3-diamine;dihydrochloride

C6H10Cl2N2

benzene-1,3-diamine;dihydrochloride

CAS541-69-5
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
541-69-5
EC Number
208-790-0
UN Number
2811
Index Number
612-148-00-9
PubChem CID
10941

Physical-chemical properties

Molecular Formula
C6H10Cl2N2
Molar Mass
181.06 g/mol
IUPAC Name
benzene-1,3-diamine;dihydrochloride

Chemical Identifiers

InChI
InChI=1S/C6H8N2.2ClH/c7-5-2-1-3-6(8)4-5;;/h1-4H,7-8H2;2*1H
InChI Key
SVTOYMIYCMHPIV-UHFFFAOYSA-N

Overview

Benzene-1,3-diamine dihydrochloride (CAS 541-69-5) is an aromatic diamine salt with significant industrial applications and notable toxicological properties. This crystalline compound, also known by its EC number 208-790-0, represents the dihydrochloride salt form of meta-phenylenediamine with a molecular formula of C6H10Cl2N2 and molecular weight of 181.06 g/mol. The compound belongs to the aromatic amine family, sharing structural similarities with related substances such as benzene-1,3-diamine and phenylhydrazine, though its salt form provides distinct handling and solubility characteristics. The substance exhibits considerable hazard potential, classified under multiple danger categories including mutagenicity (Muta. 2), acute toxicity (Acute Tox. 3), eye irritation (Eye Irrit. 2), skin sensitization (Skin Sens. 1), and aquatic toxicity. These classifications necessitate the "Danger" signal word and require GHS pictograms GHS08 (health hazard), GHS06 (acute toxicity), and GHS09 (environmental hazard). Transportation falls under ADR class 6.1, reflecting its toxic nature. Industrial applications of benzene-1,3-diamine dihydrochloride primarily include its use as an intermediate in dye and pigment manufacturing, where its diamine structure enables formation of complex chromophoric compounds. The pharmaceutical industry utilizes this compound as a building block for various drug synthesis pathways, while polymer chemistry applications leverage its bifunctional amine groups for crosslinking and curing agent formulations. Due to its hazardous nature, proper handling protocols, including appropriate personal protective equipment and ventilation systems, are essential for safe industrial use. OYSI maintains technical-grade benzene-1,3-diamine dihydrochloride inventory to support European industrial customers requiring this specialized aromatic diamine salt.

Safety & Classification

Danger
Classification:

Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acut...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H341

Suspected of causing genetic defects.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameBenzen-1,3-diamin-dihydrochlorid
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,3-diamine;dihydrochloride?

Benzene-1,3-diamine;dihydrochloride is an organic chemical compound with the molecular formula C6H10Cl2N2 and CAS number 541-69-5. This substance is the dihydrochloride salt form of meta-phenylenediamine, featuring two amino groups positioned at the 1 and 3 positions on a benzene ring. With a molecular weight of 181.06 g/mol, it is classified as a hazardous chemical requiring careful handling due to its mutagenic properties and acute toxicity.

What are the physicochemical properties of benzene-1,3-diamine;dihydrochloride?

Benzene-1,3-diamine;dihydrochloride typically appears as a crystalline solid at room temperature. As a dihydrochloride salt, it exhibits enhanced water solubility compared to its free base form, making it more suitable for aqueous applications. The compound's aromatic structure with two amino groups gives it distinctive chemical reactivity, particularly in oxidation reactions. Its salt form provides stability and improved handling characteristics while maintaining the core chemical properties of the diamine structure.

What is benzene-1,3-diamine;dihydrochloride used for?

Benzene-1,3-diamine;dihydrochloride serves as an important intermediate in chemical synthesis and manufacturing processes. It is primarily used in the production of dyes, pigments, and polymer materials due to its reactive amino groups. The compound finds applications in the pharmaceutical industry as a building block for active ingredients and in materials science for creating specialized polymers. Its dihydrochloride form offers improved stability and solubility for various industrial applications.

How to handle benzene-1,3-diamine;dihydrochloride safely?

Benzene-1,3-diamine;dihydrochloride requires strict safety protocols due to its Acute Tox. 3 classification and mutagenic properties. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection when handling this substance. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Skin sensitization potential requires particular attention to prevent direct contact. Emergency procedures and safety data sheets must be readily accessible.

How to store benzene-1,3-diamine;dihydrochloride correctly?

Benzene-1,3-diamine;dihydrochloride should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. The substance must be kept in tightly sealed containers to prevent moisture absorption and contamination. Storage areas should be equipped with appropriate spill containment measures and restricted access due to the substance's hazardous nature. Incompatible materials such as strong oxidizing agents should be stored separately to prevent dangerous reactions.

What to do in case of contact with benzene-1,3-diamine;dihydrochloride?

Benzene-1,3-diamine;dihydrochloride exposure requires immediate action depending on the contact route. For skin contact, immediately remove contaminated clothing and flush the affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water and seek medical attention due to its Eye Irrit. 2 classification. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention due to acute toxicity concerns.

How to dispose of benzene-1,3-diamine;dihydrochloride appropriately?

Benzene-1,3-diamine;dihydrochloride disposal must comply with local and European hazardous waste regulations due to its toxic and mutagenic properties. The substance cannot be disposed of through regular waste streams and requires specialized hazardous waste treatment facilities. Containers should be properly labeled and handled by certified waste management companies. Incineration at appropriate temperatures or chemical treatment may be required. Always consult local environmental authorities for specific disposal requirements and authorized disposal facilities.

How to transport benzene-1,3-diamine;dihydrochloride?

Benzene-1,3-diamine;dihydrochloride is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transportation purposes. Shipments must comply with dangerous goods regulations including proper packaging, labeling, and documentation. Vehicles must display appropriate hazard placards and drivers require ADR certification. The substance must be packaged in UN-approved containers and accompanied by proper shipping papers. Emergency response information and safety data sheets must be available during transport.

Is benzene-1,3-diamine;dihydrochloride subject to specific regulations?

Benzene-1,3-diamine;dihydrochloride falls under European REACH and CLP regulations requiring registration and classification. Its Muta. 2 classification subjects it to strict handling and exposure control requirements. While not currently listed as an SVHC, its mutagenic properties require comprehensive risk assessments and safety measures. Users must comply with occupational exposure limits and implement appropriate risk management measures. Import and use may require specific authorizations depending on quantities and applications.

Where to buy benzene-1,3-diamine;dihydrochloride in Europe?

Benzene-1,3-diamine;dihydrochloride is available through OYSI, a specialized European distributor of chemical products. As a professional chemical supplier, OYSI ensures compliance with all relevant regulations including REACH registration and proper documentation. The company provides technical support, safety data sheets, and regulatory guidance for this hazardous substance. Professional buyers can contact OYSI directly for availability, specifications, and technical assistance regarding benzene-1,3-diamine;dihydrochloride procurement and handling requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.