4-chloro-2-methylphenol

C7H7ClO

CAS1570-64-5
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
1570-64-5
EC Number
216-381-3
UN Number
3437
Index Number
604-012-00-2
PubChem CID
14855

Physical-chemical properties

Molecular Formula
C7H7ClO
Molar Mass
142.58 g/mol
IUPAC Name
4-chloro-2-methylphenol

Chemical Identifiers

InChI
InChI=1S/C7H7ClO/c1-5-4-6(8)2-3-7(5)9/h2-4,9H,1H3
InChI Key
RHPUJHQBPORFGV-UHFFFAOYSA-N

Overview

4-chloro-2-methylphenol (CAS 1570-64-5) is a chlorinated phenolic compound with antimicrobial properties and significant industrial applications. This halogenated aromatic compound, also identified by EC number 216-381-3, belongs to the chlorophenol family and exhibits molecular formula C7H7ClO with a molecular weight of 142.58 g/mol. The compound features both a chlorine substituent at the para position and a methyl group at the ortho position relative to the hydroxyl group on the benzene ring, giving it distinct chemical and biological properties compared to other phenolic derivatives. 4-chloro-2-methylphenol presents significant safety considerations requiring careful handling protocols. Classified under ADR Class 6.1, it carries acute toxicity category 3 designation and demonstrates severe skin corrosive properties (Skin Corr. 1A). The compound also poses environmental concerns with its Aquatic Acute 1 classification, indicating high toxicity to aquatic organisms. Safety protocols must address the GHS06 (skull and crossbones), GHS05 (corrosion), and GHS09 (environmental) pictograms with appropriate "Danger" signal word warnings. Industrial applications primarily focus on its biocidal properties, making it valuable in antimicrobial formulations and preservation systems. The compound serves as an intermediate in pharmaceutical synthesis and specialty chemical manufacturing. Unlike more complex biocides such as 2,2-dibromo-2-cyanoacetamide, this chlorophenol offers specific antimicrobial activity with relatively straightforward synthesis pathways. Its applications extend to wood preservation treatments and industrial disinfectant formulations where controlled antimicrobial activity is required. OYSI maintains reliable supply chains for 4-chloro-2-methylphenol, supporting European industrial customers with consistent quality standards and comprehensive technical documentation for safe handling and application development.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Skin Corr. 1A; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H314

Causes severe skin burns and eye damage.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3437
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name4-Chlor-o-cresol, fest
Marine PollutantNo

Frequently Asked Questions

What is 4-chloro-2-methylphenol?

4-chloro-2-methylphenol is an organochlorine compound with the molecular formula C7H7ClO and CAS number 1570-64-5. This phenolic compound features a chlorine atom at position 4 and a methyl group at position 2 on the benzene ring, with a molecular weight of 142.58 g/mol. It is classified as a hazardous substance with acute toxicity, skin corrosive properties, and aquatic toxicity characteristics.

What are the physicochemical properties of 4-chloro-2-methylphenol?

4-chloro-2-methylphenol is typically a solid or crystalline substance at room temperature with characteristic phenolic properties. As a chlorinated phenol derivative, it exhibits moderate to limited water solubility and has antiseptic properties. The compound has a molecular weight of 142.58 g/mol and contains both hydrophilic (hydroxyl) and lipophilic (chlorinated aromatic) characteristics, making it suitable for various chemical applications.

What is 4-chloro-2-methylphenol used for?

4-chloro-2-methylphenol is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a precursor for manufacturing various antimicrobial agents, preservatives, and disinfectants. The compound is also utilized in the production of antioxidants, polymer additives, and as a building block for more complex organic molecules in fine chemical synthesis applications.

How to handle 4-chloro-2-methylphenol safely?

4-chloro-2-methylphenol requires strict safety measures due to its Acute Tox. 3 and Skin Corr. 1A classifications. Essential PPE includes chemical-resistant gloves, safety goggles, face shield, and protective clothing to prevent skin and eye contact. Work in well-ventilated areas or under fume extraction. Avoid inhalation, ingestion, and direct contact. Emergency eyewash stations and safety showers must be readily accessible when handling this corrosive substance.

How to store 4-chloro-2-methylphenol correctly?

4-chloro-2-methylphenol must be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep away from strong oxidizers, bases, and reducing agents. Storage areas should be equipped with appropriate containment measures and clearly labeled with hazard warnings. Maintain temperatures below decomposition point and ensure containers are properly grounded to prevent static electricity buildup.

What to do in case of contact with 4-chloro-2-methylphenol?

Skin contact requires immediate removal of contaminated clothing and flushing the affected area with copious amounts of water for at least 15 minutes due to its corrosive nature. For eye contact, rinse immediately with water for 15-20 minutes and seek medical attention. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Contact emergency services for severe exposures.

How to dispose of 4-chloro-2-methylphenol properly?

4-chloro-2-methylphenol must be disposed of as hazardous waste through licensed waste management companies in compliance with local and EU regulations. The substance cannot be disposed of in regular waste streams due to its toxicity and environmental hazards. Incineration at appropriate high-temperature facilities or specialized chemical treatment may be required. Always consult waste disposal experts and follow applicable environmental protection guidelines for proper disposal methods.

How to transport 4-chloro-2-methylphenol?

4-chloro-2-methylphenol is classified under ADR Class 6.1 (Toxic substances), Packing Group II, indicating moderate danger during transport. It requires appropriate UN-approved packaging, proper labeling with GHS06, GHS05, and GHS09 pictograms, and transport documentation. Vehicles must comply with ADR regulations for toxic substances, including proper ventilation, emergency equipment, and driver certification. Professional hazardous goods carriers should handle transportation to ensure regulatory compliance.

Is 4-chloro-2-methylphenol subject to specific regulations?

4-chloro-2-methylphenol is regulated under EU REACH and CLP regulations, requiring registration, classification, and labeling as Acute Tox. 3, Skin Corr. 1A, and Aquatic Acute 1. It is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational exposure limits, environmental discharge restrictions, and safety data sheet requirements. Additional national regulations may apply for specific uses or quantities.

Where to buy 4-chloro-2-methylphenol in Europe?

4-chloro-2-methylphenol is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to industrial and professional customers across Europe, ensuring full regulatory compliance, proper documentation, and safe packaging. As an established chemical distributor, OYSI offers technical support, safety data sheets, and reliable supply chain management for businesses requiring this specialized chemical intermediate for their manufacturing processes.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.