4-amino-3-fluorophenol

4-amino-3-fluorophenol is an aromatic organic compound with the molecular formula C6H6FNO and CAS number 399-95-1. This fluorinated phenol derivative contains both amino and hydroxyl functional groups on a benzene ring, with a molecular weight of 127.12 g/mol. It is classified as a Category 1B carcinogen and requires careful handling due to its hazardous properties including acute toxicity and skin sensitization potential.

4-amino-3-fluorophenol is a solid organic compound at room temperature with a molecular weight of 127.12 g/mol. As an aromatic compound containing both amino and hydroxyl groups, it typically exhibits moderate polarity and may show limited water solubility. The presence of the fluorine substituent affects its electronic properties and reactivity compared to unsubstituted aminophenols, influencing its chemical behavior in various applications.

4-amino-3-fluorophenol serves as an important intermediate in pharmaceutical synthesis and fine chemical manufacturing. Its unique substitution pattern makes it valuable for producing fluorinated pharmaceuticals, agrochemicals, and specialty chemicals. The compound is particularly useful in medicinal chemistry for developing drugs where fluorine substitution can enhance metabolic stability, bioavailability, or binding affinity. It may also be used in dye synthesis and other specialized chemical applications.

4-amino-3-fluorophenol requires strict safety precautions due to its carcinogenic properties (Category 1B) and acute toxicity. Essential protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas or fume hoods. Avoid skin contact and inhalation as it may cause sensitization. Work in designated areas with proper containment measures, and ensure personnel are trained in handling carcinogenic substances according to workplace safety regulations.

4-amino-3-fluorophenol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Keep containers in secondary containment and store separately from oxidizing agents, acids, and bases. Storage areas must be clearly labeled as containing carcinogenic material with restricted access. Maintain temperatures below 25°C and protect from light and moisture. Implement inventory controls and regular container inspections for leak detection.

In case of skin contact with 4-amino-3-fluorophenol, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Seek medical attention promptly in all cases, especially given the carcinogenic nature of this substance. Do not induce vomiting if ingested.

4-amino-3-fluorophenol requires disposal as hazardous waste due to its carcinogenic classification and environmental hazard properties. Contact licensed hazardous waste disposal companies authorized to handle Category 1B carcinogens. Do not discharge to drains, soil, or waterways as it poses aquatic chronic toxicity risks. Dispose of in accordance with local, national, and EU regulations including the Waste Framework Directive. Maintain disposal records and waste transfer documentation.

4-amino-3-fluorophenol is classified under ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation. Packages must be properly labeled with UN identification numbers and hazard labels including GHS pictograms GHS07, GHS08, and GHS09. Use appropriate packaging that meets ADR requirements for Class 9 substances. Transport documentation must include proper shipping names, hazard classes, and emergency response information. Only use carriers certified for dangerous goods transport.

4-amino-3-fluorophenol is subject to comprehensive EU chemical regulations including REACH registration requirements and CLP classification obligations. As a Category 1B carcinogen, it falls under strict occupational exposure limits and workplace safety regulations. While not currently listed as an SVHC, its hazard profile requires compliance with worker protection directives and environmental regulations. Users must maintain safety data sheets, implement risk management measures, and follow notification requirements for carcinogenic substance use.

4-amino-3-fluorophenol is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support. As an established chemical distributor, OYSI ensures reliable supply chains for laboratory and industrial customers across Europe. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements.