4-amino-3-fluorophenol

4-amino-3-fluorophenol is an aromatic organic compound with the molecular formula C6H6FNO and CAS number 399-95-1. This fluorinated phenol derivative contains both amino and hydroxyl functional groups on a benzene ring, with a molecular weight of 127.12 g/mol. It is classified as a Category 1B carcinogen and requires careful handling due to its hazardous properties including acute toxicity and skin sensitization potential.

4-amino-3-fluorophenol is a solid aromatic compound at room temperature with a molecular weight of 127.12 g/mol. As a substituted phenol, it typically appears as a crystalline powder and exhibits moderate polarity due to its amino and hydroxyl groups. The fluorine substitution affects its electronic properties and reactivity. Its solubility characteristics are influenced by the polar functional groups, making it partially soluble in polar solvents.

4-amino-3-fluorophenol serves as an important intermediate in pharmaceutical and chemical synthesis processes. It is commonly used in the manufacture of fluorinated pharmaceutical compounds, dyes, and specialty chemicals. The compound's unique substitution pattern makes it valuable for producing biologically active molecules and advanced materials. Its applications are primarily in research and development laboratories and pharmaceutical manufacturing facilities.

4-amino-3-fluorophenol requires strict safety measures due to its carcinogenic and sensitizing properties. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or fume hoods to prevent inhalation exposure. Avoid skin contact and ingestion. Regular health monitoring of exposed workers is recommended due to the substance's acute toxicity and carcinogenic classification.

4-amino-3-fluorophenol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers protected from light and moisture to prevent degradation. Storage areas must be equipped with appropriate containment measures and restricted access due to the carcinogenic nature of the substance. Maintain proper inventory records and ensure containers are properly labeled according to GHS requirements.

Immediate action is required following exposure to 4-amino-3-fluorophenol due to its toxic properties. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. In case of eye contact, flush immediately with clean water for at least 15 minutes. If inhaled, move to fresh air immediately. Seek medical attention promptly for any exposure, especially given the substance's carcinogenic classification and sensitization potential.

4-amino-3-fluorophenol must be disposed of as hazardous waste through licensed waste management companies due to its carcinogenic and environmentally hazardous properties. The substance cannot be disposed of in regular waste streams or sewage systems. Follow local and national regulations for hazardous waste disposal, including proper documentation and manifesting. Incineration at high temperatures in authorized facilities is typically the preferred disposal method for this type of aromatic compound.

4-amino-3-fluorophenol is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. Packages must be properly marked, labeled, and documented according to dangerous goods regulations. Use appropriate packaging that meets UN specification requirements for Class 9 materials. Transport vehicles must carry proper emergency response information and drivers need hazardous materials training certification. Ensure compliance with international transport regulations for cross-border shipments.

4-amino-3-fluorophenol is subject to multiple regulatory frameworks including REACH registration requirements for European market access and CLP classification as a Category 1B carcinogen. The substance requires safety data sheets, proper labeling with GHS08, GHS07, and GHS09 pictograms, and the danger signal word. While not currently listed as an SVHC, its carcinogenic classification subjects it to strict occupational health regulations and potential restrictions on certain uses.

4-amino-3-fluorophenol is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides properly classified and documented chemical products with full regulatory compliance including safety data sheets and transport documentation. As a hazardous substance requiring specialized handling, it is essential to source from qualified suppliers who understand the regulatory requirements and safety protocols necessary for this carcinogenic material.