Benzene-1,4-diol

C6H6O2

benzene-1,4-diol

CAS123-31-9
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
123-31-9
EC Number
204-617-8
UN Number
3077
Index Number
604-005-00-4
PubChem CID
785

Physical-chemical properties

Molecular Formula
C6H6O2
Molar Mass
110.11 g/mol
IUPAC Name
benzene-1,4-diol

Chemical Identifiers

InChI
InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
InChI Key
QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Overview

Benzene-1,4-diol (CAS 123-31-9) is an aromatic diol compound with two hydroxyl groups positioned para to each other on the benzene ring. This organic chemical, also known by its EC number 204-617-8, represents a fundamental building block in industrial chemistry with the molecular formula C6H6O2 and a molecular weight of 110.11 g/mol. The compound features a symmetrical structure where two hydroxyl groups are attached to opposite carbons of a benzene ring, creating a highly reactive and versatile chemical intermediate. The substance exhibits significant safety considerations, classified under multiple hazard categories including carcinogenicity (Category 2), mutagenicity (Category 2), and acute toxicity (Category 4). Additional classifications include serious eye damage, skin sensitization potential, and aquatic toxicity concerns. These properties necessitate careful handling protocols and appropriate personal protective equipment during industrial applications. The compound requires ADR Class 9 transport classification, reflecting its miscellaneous dangerous goods status. Industrially, benzene-1,4-diol serves as a crucial intermediate in polymer synthesis, particularly in the production of engineering plastics and specialty resins. The chemical industry utilizes this compound extensively in the manufacture of antioxidants and rubber processing additives. Its reactive hydroxyl groups make it valuable for developing pharmaceutical intermediates and fine chemicals, where it may be found in synthesis pathways alongside compounds such as (5-acetyl-2-acetyloxyphenyl)methyl acetate in certain specialized applications. The compound's industrial significance stems from its ability to undergo various chemical transformations, including oxidation, alkylation, and condensation reactions. These properties make it indispensable for creating complex molecular structures in specialty chemical manufacturing. OYSI maintains reliable supply chains for benzene-1,4-diol to support European industrial customers requiring this essential chemical intermediate.

Safety & Classification

Danger
Classification:

Carc. 2; Muta. 2; Acute Tox. 4 *; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H341

Suspected of causing genetic defects.

H302

Harmful if swallowed.

H318

Causes serious eye damage.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameHydrochinon, fest
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,4-diol?

Benzene-1,4-diol is an organic chemical compound with the molecular formula C6H6O2 and CAS number 123-31-9. Also known as hydroquinone, it consists of a benzene ring with two hydroxyl groups positioned opposite each other (para position). With a molecular weight of 110.11 g/mol, this aromatic diol is classified as a hazardous substance due to its carcinogenic, mutagenic, and sensitizing properties, requiring careful handling in industrial applications.

What are the physicochemical properties of benzene-1,4-diol?

Benzene-1,4-diol appears as white crystalline needles or powder at room temperature with a characteristic phenolic odor. It has a melting point of approximately 170°C and is moderately soluble in water, highly soluble in alcohol and ether. The compound is prone to oxidation, particularly when exposed to light and air, which can cause discoloration. Its aromatic structure provides stability while the hydroxyl groups confer polar characteristics affecting its solubility profile.

What is benzene-1,4-diol used for?

Benzene-1,4-diol serves primarily as a reducing agent and antioxidant in photographic processing, acting as a developer in black-and-white photography. It is extensively used in the production of polymers, particularly as a monomer for engineering plastics and as a polymerization inhibitor. Additional applications include its use in rubber processing, cosmetic formulations as a skin-lightening agent, and as an intermediate in the synthesis of dyes, pharmaceuticals, and other fine chemicals.

How to handle benzene-1,4-diol safely?

Benzene-1,4-diol requires strict safety precautions due to its carcinogenic and mutagenic properties. Mandatory personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection to prevent inhalation. Work should be conducted in well-ventilated areas or under fume extraction systems. Avoid skin and eye contact, and prevent dust formation. Emergency shower and eyewash stations must be readily accessible, and workers should receive appropriate training on hazard recognition and safe handling procedures.

How to store benzene-1,4-diol correctly?

Benzene-1,4-diol must be stored in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and oxidizing agents. Use original containers or compatible materials, ensuring tight closure to prevent moisture absorption and oxidation. Storage areas should be equipped with appropriate spill containment and emergency equipment. Segregate from incompatible materials such as strong oxidizers, acids, and bases. Implement inventory rotation using first-in-first-out principles to minimize degradation over time.

What to do in case of contact with benzene-1,4-diol?

Benzene-1,4-diol contact requires immediate action due to its toxic properties. For skin contact, remove contaminated clothing and flush affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse immediately with clean water for 15-20 minutes and seek medical attention. If inhaled, move person to fresh air and monitor breathing. For ingestion, do not induce vomiting and seek immediate medical help. Always consult a physician and provide the safety data sheet.

How to dispose of benzene-1,4-diol properly?

Benzene-1,4-diol disposal must comply with local and national hazardous waste regulations due to its classification as dangerous waste. The substance cannot be disposed of in regular waste streams and requires specialized treatment through licensed waste management facilities. Typical disposal methods include high-temperature incineration with proper emission controls or chemical treatment to neutralize its hazardous properties. Maintain detailed disposal records and use only authorized waste carriers for transportation to approved facilities.

How to transport benzene-1,4-diol?

Benzene-1,4-diol is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling with Class 9 hazard labels, and proper shipping documentation including dangerous goods declarations. Vehicles must carry appropriate emergency equipment and drivers need ADR certification. Packages must be secured to prevent movement during transit and marked with proper shipping names, UN numbers, and hazard warnings according to international dangerous goods regulations.

Is benzene-1,4-diol subject to specific regulations?

Benzene-1,4-diol is subject to comprehensive European chemical regulations under REACH and CLP frameworks, requiring registration, classification, and safety data sheet provisions. Its carcinogenic and mutagenic properties mandate strict occupational exposure limits and workplace risk assessments. The substance may be subject to additional restrictions in cosmetic applications and requires authorization for certain uses. Companies must implement appropriate risk management measures and maintain compliance with worker protection directives and environmental discharge standards.

Where to buy benzene-1,4-diol in Europe?

Benzene-1,4-diol is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across Europe. As a professional chemical distributor, OYSI provides high-quality benzene-1,4-diol with proper documentation, safety data sheets, and regulatory compliance support. Their European network ensures reliable supply chains and technical expertise for industrial applications. Contact OYSI directly for specific grades, quantities, pricing, and delivery options tailored to your industrial requirements and regulatory obligations.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.