Benzene-1,4-diol

C6H6O2

benzene-1,4-diol

CAS123-31-9
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
123-31-9
EC Number
204-617-8
UN Number
3077
Index Number
604-005-00-4
PubChem CID
785

Physical-chemical properties

Molecular Formula
C6H6O2
Molar Mass
110.11 g/mol
IUPAC Name
benzene-1,4-diol

Chemical Identifiers

InChI
InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
InChI Key
QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Overview

Benzene-1,4-diol (CAS 123-31-9) is an organic phenolic compound with strong reducing properties and industrial applications in photography and polymer production. This dihydroxybenzene derivative, commonly known as hydroquinone, represents one of three isomeric forms of benzenediol compounds. With the molecular formula C6H6O2 and a molecular weight of 110.11 g/mol, this white crystalline solid exhibits notable chemical reactivity due to its two hydroxyl groups positioned para to each other on the benzene ring. The compound's European Chemical Number (EC 204-617-8) reflects its established presence in commercial chemical markets across Europe. From a safety perspective, benzene-1,4-diol carries significant hazard classifications including carcinogenicity (Category 2), mutagenicity (Category 2), and acute toxicity warnings. The substance requires careful handling protocols due to its potential for eye damage, skin sensitization, and environmental impact on aquatic systems. Transport regulations classify it under ADR Class 9 miscellaneous dangerous substances, emphasizing the need for proper packaging and documentation during shipment. Industrial applications primarily center on photographic processing, where it serves as a developing agent, and rubber manufacturing as an antioxidant and polymerization inhibitor. The chemical industry also utilizes this compound in the synthesis of various derivatives and specialty chemicals. Unlike complex pharmaceutical intermediates such as 1-(2-amino-5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone;hydrochloride, benzene-1,4-diol maintains relatively straightforward synthetic pathways from readily available starting materials. OYSI maintains reliable supply chains for benzene-1,4-diol, ensuring consistent availability for European industrial customers requiring this essential chemical intermediate.

Safety & Classification

Danger
Classification:

Carc. 2; Muta. 2; Acute Tox. 4 *; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H341

Suspected of causing genetic defects.

H302

Harmful if swallowed.

H318

Causes serious eye damage.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameHydrochinon, fest
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,4-diol?

Benzene-1,4-diol is an organic chemical compound with the molecular formula C6H6O2 and CAS number 123-31-9. Also known as hydroquinone, it consists of a benzene ring with two hydroxyl groups positioned opposite each other. With a molecular weight of 110.11 g/mol, this aromatic diol is classified as a hazardous substance due to its potential carcinogenic and mutagenic properties, requiring careful handling in industrial applications.

What are the physicochemical properties of benzene-1,4-diol?

Benzene-1,4-diol appears as white crystalline needles or powder at room temperature. It has a molecular weight of 110.11 g/mol and exhibits good solubility in water, alcohol, and ether. The compound is sensitive to light and air, readily oxidizing to form quinones. It sublimes at room temperature and has a characteristic phenolic odor. Due to its aromatic structure with two hydroxyl groups, it demonstrates both reducing and chelating properties.

What is benzene-1,4-diol used for?

Benzene-1,4-diol serves primarily as a reducing agent and antioxidant in various industrial applications. It is widely used in photographic developers, rubber processing as an antioxidant, and in the production of dyes and pigments. The compound also finds applications in cosmetic formulations, polymerization inhibitors, and as an intermediate in pharmaceutical synthesis. Its reducing properties make it valuable in analytical chemistry and various chemical manufacturing processes.

How to handle benzene-1,4-diol safely?

Benzene-1,4-diol requires strict safety measures due to its carcinogenic and mutagenic classification. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work in well-ventilated areas or under fume hoods to prevent inhalation. Avoid skin and eye contact completely. Use non-sparking tools and prevent dust formation. Ensure emergency eyewash stations and safety showers are readily accessible during handling operations.

How to store benzene-1,4-diol correctly?

Benzene-1,4-diol must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers protected from light and air to prevent oxidation. Store separately from strong oxidizing agents, bases, and incompatible materials. Maintain storage temperatures below 25°C and ensure the storage area is equipped with appropriate spill containment measures. Regular inventory checks help prevent degradation over time.

What to do in case of contact with benzene-1,4-diol?

Immediate action is crucial upon contact with benzene-1,4-diol. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with clean water for 15-20 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, rinse mouth and seek immediate medical attention. Always consult a physician after any exposure incident.

How to dispose of benzene-1,4-diol appropriately?

Benzene-1,4-diol disposal must comply with local and European waste regulations as hazardous chemical waste. Never dispose of this substance through regular waste streams or pour down drains. Contact licensed hazardous waste disposal companies for proper treatment, which typically involves high-temperature incineration in specialized facilities. Maintain proper documentation of waste disposal activities. Empty containers may also require special handling due to potential residue contamination.

How to transport benzene-1,4-diol?

Benzene-1,4-diol is classified under ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. It requires appropriate packaging according to ADR regulations, including proper labeling with GHS pictograms (GHS08, GHS07, GHS05, GHS09) and hazard information. Transport documents must include the correct shipping name and UN identification number. Only qualified carriers with proper training and equipment should handle transportation of this hazardous material.

Is benzene-1,4-diol subject to specific regulations?

Benzene-1,4-diol is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification standards. It carries multiple hazard classifications including carcinogenic (Carc. 2) and mutagenic (Muta. 2) properties. While not currently listed as a Substance of Very High Concern (SVHC), its hazardous properties require strict compliance with occupational health and safety regulations. Users must maintain safety data sheets and implement appropriate risk management measures.

Where to buy benzene-1,4-diol in Europe?

Benzene-1,4-diol is available through OYSI, a professional European distributor of technical chemicals. As specialized chemical distributors, OYSI provides this compound with full regulatory compliance including proper documentation, safety data sheets, and appropriate packaging. Professional customers can contact OYSI for availability, technical specifications, and delivery options across Europe. Given the hazardous nature of this substance, purchases are typically restricted to qualified industrial and research users only.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.