2,3,4,5-tetrachlorobenzoyl chloride

2,3,4,5-tetrachlorobenzoyl chloride is an organochlorine compound with the molecular formula C7HCl5O and CAS number 42221-52-3. This chemical substance belongs to the family of chlorinated benzoyl chlorides, featuring four chlorine atoms attached to the benzene ring and an acyl chloride functional group. With a molecular weight of 278.3 g/mol, it is classified as a hazardous substance requiring careful handling due to its corrosive and sensitizing properties.

2,3,4,5-tetrachlorobenzoyl chloride typically appears as a solid or crystalline material at room temperature. As an acyl chloride, it is highly reactive with water and moisture, readily hydrolyzing to form the corresponding carboxylic acid and hydrochloric acid. The compound is generally soluble in organic solvents but reacts violently with protic solvents. It may emit a pungent, acrid odor characteristic of acyl chlorides and should be handled under anhydrous conditions.

2,3,4,5-tetrachlorobenzoyl chloride serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It functions as an acylating agent in the preparation of amides, esters, and other derivatives through nucleophilic acyl substitution reactions. The compound is valuable in fine chemical synthesis, particularly in the development of agrochemicals, pharmaceuticals, and specialty chemicals where the tetrachlorinated benzoyl moiety is required as a building block for more complex molecular structures.

2,3,4,5-tetrachlorobenzoyl chloride requires strict safety protocols due to its Skin Corr. 1B and Skin Sens. 1 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work must be conducted in a well-ventilated area or under a fume hood to prevent inhalation exposure. Avoid contact with skin, eyes, and clothing. Handle under anhydrous conditions to prevent violent hydrolysis reactions. Emergency eyewash stations and safety showers should be readily accessible.

2,3,4,5-tetrachlorobenzoyl chloride must be stored in a cool, dry place away from moisture and water sources to prevent hydrolysis. Use tightly sealed, corrosion-resistant containers in a well-ventilated storage area. Keep away from incompatible materials such as alcohols, amines, and bases. Storage areas should be equipped with appropriate spill containment and ventilation systems. Maintain storage temperatures below recommended limits and protect from direct sunlight. Regular container inspection is essential to detect any signs of degradation or leakage.

2,3,4,5-tetrachlorobenzoyl chloride exposure requires immediate first aid due to its corrosive nature. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water for several minutes and remove contact lenses if present. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure incident.

2,3,4,5-tetrachlorobenzoyl chloride disposal must comply with local and national hazardous waste regulations. The substance cannot be disposed of through regular waste streams due to its corrosive properties and chlorinated nature. Arrange disposal through licensed hazardous waste contractors who specialize in halogenated organic compounds. Small quantities may be carefully neutralized under controlled conditions before disposal, but this should only be performed by trained professionals. Maintain detailed disposal records as required by environmental regulations.

2,3,4,5-tetrachlorobenzoyl chloride is classified as ADR Class 8 (corrosive substances), Packing Group II, requiring specific transport protocols. Packaging must comply with UN specifications for corrosive materials and be properly labeled with appropriate hazard placards. Transport vehicles must carry emergency response information and spill cleanup materials. Drivers require ADR certification for dangerous goods transport. Shipments must include proper documentation including safety data sheets and emergency contact information. Avoid transport during extreme weather conditions.

2,3,4,5-tetrachlorobenzoyl chloride is subject to multiple regulatory frameworks including REACH registration requirements in Europe and CLP classification as Acute Tox. 4, Skin Corr. 1B, and Skin Sens. 1. While not currently listed as an SVHC (Substance of Very High Concern), it requires safety data sheet provision and proper hazard communication. Industrial users must comply with occupational exposure limits and workplace safety regulations. Import/export may require additional permits depending on jurisdiction. Regular regulatory monitoring is essential for compliance.

2,3,4,5-tetrachlorobenzoyl chloride is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides comprehensive technical support, regulatory documentation, and reliable supply chain management for this specialized chemical intermediate. The company ensures full compliance with European chemical regulations including REACH and CLP requirements. Contact OYSI directly for specific availability, packaging options, and technical specifications to meet your application requirements.