2-piperazin-1-ylethanamine

2-piperazin-1-ylethanamine is an organic chemical compound with the molecular formula C6H15N3 and CAS number 140-31-8. This diamine derivative features a piperazine ring connected to an ethylamine chain, giving it a molecular weight of 129.2 g/mol. It is classified as a corrosive substance with acute toxicity properties and skin sensitization potential, requiring careful handling in industrial applications.

2-piperazin-1-ylethanamine is typically a liquid or solid at room temperature with basic properties due to its amine functional groups. The compound exhibits high water solubility owing to its nitrogen-containing structure and ability to form hydrogen bonds. Its molecular structure includes both primary and secondary amine groups, making it reactive toward acids and electrophilic compounds in various chemical processes.

2-piperazin-1-ylethanamine serves primarily as an intermediate in pharmaceutical synthesis and chemical manufacturing. It is commonly used in the production of various drugs, particularly those targeting central nervous system disorders, due to its piperazine backbone. The compound also finds applications in polymer chemistry, surfactant production, and as a building block for specialty chemicals in research and development activities.

2-piperazin-1-ylethanamine requires strict safety measures due to its corrosive and toxic nature. Personnel must wear chemical-resistant gloves, safety goggles, and protective clothing when handling this substance. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Given its Skin Corr. 1B classification, immediate skin contact must be avoided, and emergency eyewash stations should be readily accessible.

2-piperazin-1-ylethanamine must be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. The storage area should be equipped with appropriate spill containment measures and restricted to authorized personnel only. Given its corrosive properties, containers should be made of compatible materials and regularly inspected for integrity to prevent leaks or contamination.

Immediate action is required upon contact with 2-piperazin-1-ylethanamine due to its corrosive nature. For skin contact, immediately remove contaminated clothing and rinse the affected area with plenty of water for at least 15 minutes. In case of eye contact, flush eyes thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air immediately and contact emergency medical services if breathing difficulties occur.

2-piperazin-1-ylethanamine disposal must comply with local and national hazardous waste regulations due to its toxic and corrosive properties. The substance should never be discharged into sewers, waterways, or regular waste streams. Disposal must be performed by licensed hazardous waste contractors through appropriate treatment methods such as controlled incineration or chemical neutralization, following all applicable environmental protection guidelines.

2-piperazin-1-ylethanamine is classified as ADR Class 8 (corrosive substances), Packing Group III for transportation purposes. Shipments must use appropriate UN-approved packaging designed for corrosive materials and bear proper hazard labels and documentation. Transport vehicles must comply with ADR regulations, including proper placarding, and drivers must be trained in hazardous materials handling and emergency response procedures.

2-piperazin-1-ylethanamine is subject to various chemical regulations including REACH registration requirements in the European Union and CLP classification standards. While not currently listed as a Substance of Very High Concern (SVHC), it must comply with standard chemical safety protocols, workplace exposure limits, and environmental protection measures. Manufacturers and importers must maintain safety data sheets and ensure proper risk assessments are conducted.

2-piperazin-1-ylethanamine is available through OYSI, a trusted European distributor of specialty chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains across Europe with proper documentation, quality assurance, and regulatory compliance support. As an established chemical distributor, OYSI ensures that all products meet European standards and can provide technical support for various industrial applications requiring this specialized compound.