2-methylpropanoyl chloride

2-methylpropanoyl chloride is an organic chemical compound with the molecular formula C4H7ClO and CAS number 79-30-1. It belongs to the family of acyl chlorides, characterized by the presence of a carbonyl group bonded to a chlorine atom. This branched-chain acid chloride has a molecular weight of 106.55 g/mol and is classified as both a flammable liquid and highly corrosive substance, requiring careful handling in industrial applications.

2-methylpropanoyl chloride is a colorless to pale yellow liquid with a pungent, acrid odor typical of acid chlorides. It has high reactivity with water and alcohols, leading to hydrolysis and formation of corresponding acids. The compound is highly volatile and flammable, classified as Flammable Liquid Category 2. It readily dissolves in organic solvents but reacts violently with water, making it moisture-sensitive and requiring anhydrous storage conditions.

2-methylpropanoyl chloride is primarily used as an acylating agent in organic synthesis for the production of esters, amides, and other derivatives. It serves as a key intermediate in pharmaceutical manufacturing, particularly in the synthesis of active pharmaceutical ingredients. The compound is also utilized in the production of specialty chemicals, agrochemicals, and as a reagent in laboratory research for introducing isobutyryl groups into organic molecules.

2-methylpropanoyl chloride requires strict safety measures due to its corrosive and flammable nature. Essential PPE includes chemical-resistant gloves, safety goggles, face shields, and acid-resistant clothing. Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation of vapors. Avoid contact with water, alcohols, and bases. Keep away from ignition sources and heat. Emergency eyewash stations and safety showers should be readily accessible.

2-methylpropanoyl chloride must be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from heat sources and ignition. Storage temperature should be kept below 25°C to prevent decomposition. The compound is incompatible with water, alcohols, amines, and strong bases. Storage areas should be equipped with appropriate fire suppression systems and spill containment measures. Regular inspection of containers for corrosion is essential.

2-methylpropanoyl chloride contact requires immediate emergency response due to its highly corrosive nature. For skin contact, immediately remove contaminated clothing and flush affected areas with large amounts of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes while keeping eyelids open. If inhaled, move to fresh air immediately. Seek immediate medical attention in all cases. Do not induce vomiting if swallowed.

2-methylpropanoyl chloride disposal must comply with local and European waste regulations as hazardous chemical waste. The compound should never be poured down drains or disposed of with regular waste. Small quantities can be carefully hydrolyzed with ice water under controlled conditions to form less hazardous isobutyric acid. Large quantities require disposal through licensed hazardous waste contractors. All containers must be properly labeled and documented according to waste tracking requirements.

2-methylpropanoyl chloride is classified under ADR as Class 3 (Flammable Liquids), Packing Group II, indicating moderate danger level for transport. It requires appropriate UN-specification packaging and proper hazard labeling with flammable liquid and corrosive symbols. Transport vehicles must comply with ADR regulations including appropriate fire extinguishing equipment. Drivers require ADR training certification. Temperature control during transport may be necessary to prevent decomposition and pressure buildup.

2-methylpropanoyl chloride is subject to European REACH regulation requiring registration for manufacture or import above certain tonnages. Under CLP regulation, it must be classified and labeled as Flammable Liquid Category 2 and Skin Corrosive Category 1A with appropriate hazard statements and precautionary measures. It is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational exposure limits and workplace safety regulations in their respective countries.

2-methylpropanoyl chloride is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support. For procurement, customers should contact OYSI directly to discuss specific requirements, quantities, and delivery options. Professional handling and storage guidance is provided with all chemical supplies to ensure safe usage.