2-methylpropanoyl chloride

2-methylpropanoyl chloride is an organic chemical compound with the molecular formula C4H7ClO and CAS number 79-30-1. This acyl chloride has a molecular weight of 106.55 g/mol and belongs to the family of acid chlorides derived from carboxylic acids. It is classified as a flammable liquid and highly corrosive substance, requiring careful handling due to its reactive nature and potential health hazards.

2-methylpropanoyl chloride is a colorless to pale yellow liquid at room temperature with a pungent, acrid odor characteristic of acid chlorides. The compound has a molecular weight of 106.55 g/mol and reacts violently with water, producing hydrogen chloride gas and the corresponding carboxylic acid. It is soluble in organic solvents but hydrolyzes rapidly in the presence of moisture, making it highly reactive toward nucleophiles.

2-methylpropanoyl chloride is primarily used as an acylating agent in organic synthesis for the preparation of esters, amides, and other derivatives. It serves as an important intermediate in pharmaceutical manufacturing, agrochemical production, and fine chemical synthesis. The compound is particularly valuable in pharmaceutical research for introducing isobutyryl groups into target molecules and in the production of specialty chemicals requiring specific acyl functionalities.

2-methylpropanoyl chloride requires strict safety measures including chemical-resistant gloves, safety goggles, and protective clothing due to its corrosive nature (Skin Corr. 1A). Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation of vapors. Keep away from heat sources, sparks, and open flames as it is classified as Flam. Liq. 2. Always have appropriate fire extinguishing equipment and emergency eyewash stations readily available.

2-methylpropanoyl chloride must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from moisture, heat sources, and incompatible materials. Keep containers away from water and alcohols as the compound reacts violently with these substances. Storage areas should be equipped with appropriate fire suppression systems and spill containment measures. Ensure containers are properly labeled and stored according to flammable liquid storage regulations.

In case of skin contact with 2-methylpropanoyl chloride, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. Due to its highly corrosive nature (Skin Corr. 1A), seek immediate medical attention for all exposures and never induce vomiting if ingested.

2-methylpropanoyl chloride must be disposed of as hazardous waste according to local and European waste regulations. The compound cannot be disposed of in regular waste streams due to its corrosive and flammable properties. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may be carefully hydrolyzed under controlled conditions by trained personnel, but this should only be done following established safety protocols and environmental regulations.

2-methylpropanoyl chloride is classified under ADR Class 3 (flammable liquids), Packing Group II, requiring specialized transport procedures. Packages must comply with UN packaging requirements and be properly labeled with appropriate hazard placards. Transport vehicles must be equipped with appropriate safety equipment and drivers must have ADR certification. Shipping documentation must include proper shipping names, hazard classes, and emergency response information according to dangerous goods regulations.

2-methylpropanoyl chloride is subject to European REACH regulation requiring registration for manufacture or import above specified tonnages. It falls under CLP regulation with classifications as Flam. Liq. 2 and Skin Corr. 1A, requiring appropriate labeling with GHS02 and GHS05 pictograms. The compound is not currently listed as an SVHC substance, but users must comply with occupational safety regulations and may need permits for industrial use depending on quantities and applications.

2-methylpropanoyl chloride is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support. As a professional chemical distributor, OYSI ensures proper packaging, labeling, and transport of hazardous materials like 2-methylpropanoyl chloride according to European regulations and customer specifications.