Butanoyl chloride

Butanoyl chloride is an organic compound with the molecular formula C4H7ClO and a molecular weight of 106.55 g/mol. It belongs to the family of acyl chlorides, which are highly reactive chemical intermediates used in organic synthesis. This compound is classified as a flammable liquid and skin corrosive substance, requiring careful handling in industrial applications. Its CAS number is 141-75-3, making it easily identifiable in chemical databases and regulatory documents.

Butanoyl chloride is typically a colorless to pale yellow liquid at room temperature with a pungent, acrid odor characteristic of acyl chlorides. It has a molecular formula of C4H7ClO and molecular weight of 106.55 g/mol. The compound is highly reactive with water, undergoing rapid hydrolysis to form butyric acid and hydrogen chloride. It is soluble in organic solvents but reacts violently with protic solvents like alcohols and water.

Butanoyl chloride is primarily used as an acylating agent in organic synthesis for the production of esters, amides, and anhydrides. It serves as a key intermediate in pharmaceutical manufacturing, helping to introduce butanoyl groups into drug molecules. The compound is also utilized in the production of specialty chemicals, agrochemicals, and as a reagent in laboratory synthesis. Its high reactivity makes it valuable for creating carbon-carbon and carbon-heteroatom bonds in complex organic molecules.

Butanoyl chloride requires strict safety measures due to its flammable and corrosive nature. Personal protective equipment must include chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation of vapors. Keep away from heat sources, sparks, and open flames due to its flammable properties. Always use appropriate grounding procedures when transferring the material.

Butanoyl chloride must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition sources. The storage area should be equipped with appropriate fire suppression systems due to its flammable nature. Keep containers away from water and moisture to prevent hydrolysis reactions. Store separately from alcohols, amines, and other nucleophilic compounds that can react violently. Ensure storage temperature remains stable and below recommended limits.

Butanoyl chloride contact requires immediate emergency response due to its corrosive properties. For skin contact, immediately remove contaminated clothing and flush the affected area with large amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical care. Always consult safety data sheets for complete emergency procedures.

Butanoyl chloride disposal must comply with local and international hazardous waste regulations due to its corrosive and flammable classification. The compound should be neutralized carefully under controlled conditions before disposal, typically through controlled hydrolysis to form less hazardous butyric acid. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never dispose of untreated material down drains or into the environment. Maintain proper documentation of all disposal activities for regulatory compliance.

Butanoyl chloride is classified under ADR Class 3 (flammable liquids), Packing Group II, requiring specific transport regulations for dangerous goods. Packages must meet UN specification requirements and be properly labeled with appropriate hazard pictogrammes (GHS02, GHS05) and the signal word 'Danger'. Transport vehicles must comply with ADR regulations for Class 3 substances. Drivers require specialized training for dangerous goods transport, and proper shipping documentation must accompany all shipments.

Butanoyl chloride is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification as Flam. Liq. 2 and Skin Corr. 1B. The compound is not currently listed as a Substance of Very High Concern (SVHC) but must comply with standard chemical safety regulations. Users must maintain safety data sheets, conduct risk assessments, and implement appropriate risk management measures. Industrial users may need to register uses under REACH depending on tonnage and application.

Butanoyl chloride is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across the continent. OYSI provides reliable supply chains for chemical intermediates like butanoyl chloride, ensuring proper handling, documentation, and regulatory compliance. As a professional chemical distributor, OYSI can assist with technical support, safety data sheets, and regulatory guidance for industrial applications. Contact OYSI directly for availability, specifications, and delivery options for butanoyl chloride in your region.