2-methylaniline

C7H9N

CAS95-53-4
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
95-53-4
EC Number
202-429-0
UN Number
1708
Index Number
612-091-00-X
PubChem CID
7242

Physical-chemical properties

Molecular Formula
C7H9N
Molar Mass
107.15 g/mol
IUPAC Name
2-methylaniline

Chemical Identifiers

InChI
InChI=1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3
InChI Key
RNVCVTLRINQCPJ-UHFFFAOYSA-N

Overview

2-methylaniline (CAS 95-53-4) is an aromatic amine compound with significant industrial applications and notable toxicological properties requiring careful handling protocols. This organic chemical, also known as o-toluidine, belongs to the substituted aniline family and serves as a crucial intermediate in various chemical synthesis processes. With its molecular formula C7H9N and molecular weight of 107.15 g/mol, 2-methylaniline features a benzene ring substituted with both an amino group and a methyl group in the ortho position. This structural configuration distinguishes it from related compounds such as N-methylaniline, which has a different substitution pattern affecting its reactivity and applications. The compound presents significant safety considerations due to its classification as a Category 1B carcinogen under the GHS system, along with acute toxicity properties. The presence of GHS08, GHS06, and GHS09 pictograms indicates serious health hazards, acute toxicity risks, and environmental concerns. Its classification under ADR Class 6.1 reflects its status as a toxic substance requiring specialized transportation and handling procedures. Workers must implement appropriate personal protective equipment and ventilation systems when handling this material. In industrial applications, 2-methylaniline serves primarily as an intermediate in dye manufacturing, particularly for azo dyes and organic pigments. The pharmaceutical industry utilizes this compound in the synthesis of various therapeutic agents, while it also finds application in rubber chemical production. Unlike simpler aromatic amines such as phenylhydrazine, 2-methylaniline's methyl substitution provides specific reactivity patterns valuable in selective chemical transformations. OYSI maintains reliable supply capabilities for 2-methylaniline, supporting European industrial customers with technical-grade material meeting stringent quality specifications for demanding applications.

Safety & Classification

Danger
Classification:

Carc. 1B; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H331

Toxic if inhaled.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1708
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Nameo-Toluidin, flüssig
Marine PollutantNo

Frequently Asked Questions

What is 2-methylaniline?

2-methylaniline is an aromatic amine compound with the molecular formula C7H9N and CAS number 95-53-4. It consists of an aniline molecule with a methyl group attached to the second carbon of the benzene ring. With a molecular weight of 107.15 g/mol, this organic compound is classified as a carcinogenic substance (Category 1B) and poses significant health and environmental risks, requiring careful handling and specialized safety measures.

What are the physicochemical properties of 2-methylaniline?

2-methylaniline is a liquid aromatic amine that typically appears as a pale yellow to amber-colored substance at room temperature. It has a characteristic amine odor and is slightly soluble in water but readily dissolves in organic solvents like alcohol and ether. The compound has a boiling point around 200°C and a density slightly higher than water, making it important to consider these properties during handling and processing operations.

What is 2-methylaniline used for?

2-methylaniline serves primarily as an intermediate in the synthesis of dyes, pigments, and pharmaceuticals. It is commonly used in the production of azo dyes, antioxidants, and various organic compounds in the chemical industry. The compound also finds applications in research and development activities, particularly in organic synthesis processes where aromatic amines are required as building blocks for more complex molecular structures.

How to handle 2-methylaniline safely?

2-methylaniline requires strict safety protocols due to its carcinogenic properties and acute toxicity. Personnel must wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Skin and eye contact must be avoided at all costs, and proper decontamination procedures should be established before handling begins.

How to store 2-methylaniline correctly?

2-methylaniline must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Storage areas should be equipped with appropriate containment measures and restricted access due to the carcinogenic nature of the substance. The compound should be kept away from oxidizing agents, acids, and other reactive chemicals to prevent dangerous reactions or degradation.

What to do in case of contact with 2-methylaniline?

Immediate action is required in case of contact with 2-methylaniline. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air immediately. For any exposure, contact emergency medical services promptly due to the substance's toxicity.

How to dispose of 2-methylaniline appropriately?

2-methylaniline disposal must comply with local and national hazardous waste regulations due to its carcinogenic classification and environmental toxicity. The substance cannot be disposed of through regular waste streams and requires specialized hazardous waste treatment facilities. Waste containing 2-methylaniline should be collected in appropriate containers, properly labeled, and handled by licensed waste disposal companies equipped to manage carcinogenic and toxic materials safely.

How to transport 2-methylaniline?

2-methylaniline is classified under ADR Class 6.1 (toxic substances) Packing Group II, requiring specific transportation protocols for dangerous goods. Packages must be properly labeled with appropriate hazard symbols (GHS08, GHS06, GHS09) and the "Danger" signal word. Transportation vehicles must comply with ADR regulations, including proper documentation, emergency equipment, and driver certification for handling toxic substances during transit.

Is 2-methylaniline subject to specific regulations?

2-methylaniline is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification as a Category 1B carcinogen. The substance falls under strict occupational exposure limits and requires compliance with workplace safety directives. Companies handling this chemical must implement appropriate risk management measures, maintain safety data sheets, and ensure worker protection protocols meet regulatory standards for carcinogenic substances.

Where to buy 2-methylaniline in Europe?

2-methylaniline is available through OYSI, a European distributor of technical chemicals specializing in hazardous and regulated substances. As a professional chemical supplier, OYSI ensures compliance with all relevant European regulations and provides proper documentation for carcinogenic materials. Due to the substance's classification and regulatory requirements, purchases are typically restricted to qualified industrial users with appropriate handling capabilities and safety infrastructure.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.