2-fluoroacetamide

2-fluoroacetamide is an organofluorine compound with the molecular formula C2H4FNO and CAS number 640-19-7. This chemical substance has a molecular weight of 77.06 g/mol and belongs to the acetamide family, where one hydrogen atom is replaced by fluorine. It is classified as a highly toxic substance with acute toxicity categories 2 and 3, requiring careful handling and specialized safety protocols in industrial and research applications.

2-fluoroacetamide typically appears as a white to off-white crystalline solid at room temperature. The compound is polar due to the presence of both fluorine and the amide functional group, making it soluble in polar solvents like water and alcohols. Its fluorine substitution affects its chemical reactivity compared to regular acetamide, influencing its stability and interaction with biological systems. The compound requires proper identification and handling due to its hazardous nature.

2-fluoroacetamide serves primarily as a research chemical and intermediate in pharmaceutical synthesis and organic chemistry research. It is used in the development of fluorinated compounds and as a building block for more complex molecules in medicinal chemistry. The compound finds applications in academic research, pharmaceutical R&D, and specialized chemical synthesis processes. Due to its high toxicity classification, its use is restricted to professional laboratory settings with appropriate safety measures.

2-fluoroacetamide requires extreme caution during handling due to its Acute Toxicity 2 and 3 classifications. Personal protective equipment must include chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas or fume hoods. Avoid skin contact, inhalation, and ingestion completely. Work in controlled laboratory environments with emergency procedures readily available. All personnel handling this substance should receive specialized training on toxic chemical handling protocols and emergency response procedures.

2-fluoroacetamide must be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. The storage area should be restricted to authorized personnel only, with appropriate warning labels and safety data sheets readily accessible. Keep containers upright and secure to prevent spillage. Store separately from oxidizing agents, bases, and food products. Regular inventory checks and container integrity inspections are essential for safe storage management.

Immediate action is critical due to the high toxicity of 2-fluoroacetamide. For skin contact, remove contaminated clothing and rinse affected area with copious amounts of water for at least 15 minutes. If inhaled, move to fresh air immediately. In case of eye contact, flush with water for 15 minutes while holding eyelids open. For ingestion, do not induce vomiting. Seek immediate medical attention in all exposure cases and provide safety data sheet to medical personnel.

2-fluoroacetamide disposal requires compliance with local and national hazardous waste regulations due to its high toxicity classification. The substance must be collected and disposed of through licensed hazardous waste disposal companies specializing in toxic chemical waste. Never dispose of in regular trash, drains, or sewage systems. Small laboratory quantities should be neutralized or destroyed following established protocols before disposal. Maintain detailed disposal records for regulatory compliance and environmental protection.

2-fluoroacetamide is classified under ADR Class 6.1 (Toxic substances) Packing Group I, indicating high toxicity requiring strict transport regulations. Transportation must comply with dangerous goods regulations, using approved packaging and labeling with GHS06 pictogram and 'Danger' signal word. Only certified carriers experienced in hazardous materials transport should handle shipments. Proper documentation including transport documents and safety data sheets must accompany all shipments for regulatory compliance and emergency response.

2-fluoroacetamide is subject to comprehensive chemical safety regulations under REACH and CLP regulations in Europe. Its Acute Toxicity 2 and 3 classifications require compliance with strict labeling, safety data sheet, and handling requirements. While not currently listed as an SVHC substance, its high toxicity subjects it to controlled use provisions and professional handling requirements. Users must ensure regulatory compliance including proper registration, notification, and safety assessment procedures where applicable.

2-fluoroacetamide is available through OYSI, a specialized European distributor of professional chemical products. As a regulated toxic substance, it is only supplied to qualified professional users, research institutions, and industrial customers with appropriate safety credentials. OYSI ensures full regulatory compliance, proper packaging, and comprehensive safety documentation with all shipments. Contact OYSI directly to discuss specific requirements, quantities, and delivery options for your professional chemical needs.