1,4-dichloro-2-nitrobenzene

1,4-dichloro-2-nitrobenzene is an aromatic organic compound with the molecular formula C6H3Cl2NO2 and CAS number 89-61-2. This chemical features a benzene ring substituted with two chlorine atoms at positions 1 and 4, and a nitro group at position 2. With a molecular weight of 192 g/mol, it belongs to the class of chloronitrobenzenes and is classified as a Category 1B carcinogen under GHS regulations.

1,4-dichloro-2-nitrobenzene is typically a yellowish crystalline solid at room temperature with a characteristic aromatic odor. As an aromatic compound with both electron-withdrawing groups (chlorine and nitro), it exhibits limited water solubility but dissolves well in organic solvents such as alcohols, ethers, and aromatic hydrocarbons. The presence of chlorine and nitro substituents significantly influences its physical properties and chemical reactivity.

1,4-dichloro-2-nitrobenzene serves primarily as an intermediate in organic synthesis and chemical manufacturing. It is commonly used in the production of dyes, pigments, and pharmaceuticals where its reactive chlorine atoms and nitro group provide valuable synthetic pathways. The compound also finds application in the manufacture of agrochemicals and as a building block for more complex aromatic compounds in fine chemical synthesis.

1,4-dichloro-2-nitrobenzene requires careful handling due to its Category 1B carcinogenic classification. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection when handling powders or in poorly ventilated areas. Work should be conducted in well-ventilated areas or under fume hoods, avoiding skin contact and inhalation. Due to the GHS08 health hazard pictogram, strict adherence to safety protocols is mandatory.

1,4-dichloro-2-nitrobenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. As an aromatic nitro compound, it should be kept away from strong reducing agents, metals, and bases which could cause dangerous reactions. Storage areas must be clearly labeled with appropriate hazard warnings, and access should be restricted to trained personnel due to its carcinogenic properties.

In case of skin contact with 1,4-dichloro-2-nitrobenzene, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Due to its carcinogenic properties, seek medical attention promptly for any significant exposure and inform medical personnel of the chemical identity.

1,4-dichloro-2-nitrobenzene must be disposed of as hazardous waste through licensed waste management companies in compliance with local and European waste regulations. Due to its carcinogenic classification, it cannot be disposed of in regular waste streams. Incineration at licensed high-temperature facilities is typically the preferred method. Empty containers should also be treated as hazardous waste and properly decontaminated before disposal.

1,4-dichloro-2-nitrobenzene is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transport purposes. It requires appropriate hazardous goods packaging, labeling, and documentation according to ADR regulations. Vehicles must carry proper placarding, and drivers need ADR certification. The shipment must include safety data sheets and emergency response information, and be transported by companies licensed for hazardous materials transport.

1,4-dichloro-2-nitrobenzene is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification as Category 1B carcinogen. While not currently listed as an SVHC, its carcinogenic properties mean it faces strict workplace exposure limits and handling requirements under occupational health regulations. Import, use, and distribution must comply with chemical safety regulations, and downstream users must implement appropriate risk management measures.

1,4-dichloro-2-nitrobenzene is available through OYSI, a European distributor of specialty chemicals serving industrial and research customers across Europe. As a regulated carcinogenic substance, procurement requires proper documentation, safety data sheet acknowledgment, and compliance with intended use restrictions. OYSI ensures full regulatory compliance and provides technical support for safe handling and application of this specialized chemical intermediate.