Trimethyl borate

C3H9BO3

trimethyl borate

CAS121-43-7
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
Danger

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Identification

CAS Number
121-43-7
EC Number
204-468-9
UN Number
2416
Index Number
005-005-00-1
PubChem CID
8470

Physical-chemical properties

Molecular Formula
C3H9BO3
Molar Mass
103.92 g/mol
IUPAC Name
trimethyl borate

Chemical Identifiers

InChI
InChI=1S/C3H9BO3/c1-5-4(6-2)7-3/h1-3H3
InChI Key
WRECIMRULFAWHA-UHFFFAOYSA-N

Overview

Trimethyl borate (CAS 121-43-7) is an organoboron compound with flammable properties and reproductive toxicity concerns used in specialized chemical synthesis applications. This colorless liquid ester represents an important member of the alkyl borate family, characterized by its three methoxy groups bonded to a central boron atom. With the molecular formula C3H9BO3 and a molecular weight of 103.92 g/mol, trimethyl borate serves as a versatile reagent in organic chemistry and industrial processes. The compound exhibits significant volatility and flammability, requiring careful handling protocols in laboratory and manufacturing environments. Safety considerations are paramount when working with trimethyl borate, as it carries multiple hazard classifications including Flam. Liq. 3, Repr. 1B, and Acute Tox. 4 designations. The GHS pictograms GHS02, GHS08, and GHS07 indicate fire hazard, health hazard, and harmful properties respectively. Its ADR Class 3 classification reflects its flammable liquid nature, necessitating appropriate storage and transportation measures. Unlike structurally different compounds such as ethylbenzene or styrene which are primarily hydrocarbon-based, trimethyl borate's boron-oxygen framework provides unique reactivity patterns. Industrial applications of trimethyl borate include its use as a catalyst in organic synthesis reactions, particularly in esterification processes and as a dehydrating agent. The compound also finds application in the production of specialized boron-containing materials and as an intermediate in pharmaceutical synthesis. Additionally, it serves as a flame retardant additive in certain polymer formulations. OYSI maintains regular availability of trimethyl borate to support diverse industrial and research applications across European markets.

Safety & Classification

Danger
Classification:

Flam. Liq. 3; Repr. 1B; Acute Tox. 4 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H312

Harmful in contact with skin.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2416
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameTrimethylborat
Marine PollutantNo

Frequently Asked Questions

What is trimethyl borate?

Trimethyl borate is an organoboron compound with the molecular formula C3H9BO3 and CAS number 121-43-7. This chemical substance has a molecular weight of 103.92 g/mol and belongs to the class of borate esters. It is classified as a flammable liquid with reproductive toxicity and acute toxicity properties, making it a hazardous substance that requires careful handling and appropriate safety measures during use and storage.

What are the physicochemical properties of trimethyl borate?

Trimethyl borate is a colorless liquid at room temperature with a characteristic odor. It has a relatively low boiling point and is volatile under normal conditions. The compound is miscible with most organic solvents but reacts with water, undergoing hydrolysis to form boric acid and methanol. Its flammable nature is reflected in its GHS classification as Flam. Liq. 3, indicating moderate fire hazard potential.

What is trimethyl borate used for?

Trimethyl borate is primarily used as a reagent in organic synthesis, particularly in the preparation of organoborane compounds and as a source of boron in various chemical reactions. It serves as an intermediate in pharmaceutical manufacturing, acts as a catalyst in certain polymerization processes, and is employed in the production of flame retardants. Additionally, it finds applications in the electronics industry for specialized chemical processes.

How to handle trimethyl borate safely?

Trimethyl borate must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection when necessary. Work should be conducted in well-ventilated areas or under fume hoods due to its volatile nature and toxicity. Avoid contact with skin, eyes, and inhalation of vapors. Keep away from ignition sources as it is classified as a flammable liquid. Pregnant women should avoid exposure due to its reproductive toxicity classification.

How to store trimethyl borate correctly?

Trimethyl borate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition points. Keep containers away from moisture as the compound hydrolyzes in the presence of water. Storage areas should comply with flammable liquid storage requirements and maintain temperatures below the substance's flash point. Ensure compatibility with storage materials and avoid contact with oxidizing agents or strong bases.

What to do in case of contact with trimethyl borate?

In case of skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with plenty of clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. If ingested, do not induce vomiting and seek immediate medical attention. Always consult a physician in case of exposure.

How to dispose of trimethyl borate appropriately?

Trimethyl borate must be disposed of according to local and national hazardous waste regulations. It cannot be disposed of in regular waste streams due to its flammable and toxic properties. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small quantities should be allowed to evaporate in a well-ventilated area under controlled conditions, while larger amounts require professional hazardous waste management services following applicable environmental regulations.

How to transport trimethyl borate?

Trimethyl borate is classified under ADR class 3 (flammable liquids) with packing group II, indicating moderate danger level during transport. It must be packaged in UN-approved containers and labeled with appropriate hazard markings including GHS02, GHS07, and GHS08 pictograms. Transport vehicles must comply with ADR requirements for flammable liquids, and drivers need appropriate training. Emergency response information must accompany shipments, and specific routing restrictions may apply.

Is trimethyl borate subject to specific regulations?

Trimethyl borate is subject to REACH regulation in Europe and must comply with CLP classification requirements. It is classified as Repr. 1B (reproductive toxicant category 1B), which subjects it to authorization procedures and strict labeling requirements. The substance carries the signal word 'Danger' and requires safety data sheets for commercial use. It is not currently listed as a SVHC (Substance of Very High Concern) but may be subject to future regulatory restrictions.

Where to buy trimethyl borate in Europe?

Trimethyl borate is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides high-quality trimethyl borate with appropriate documentation including safety data sheets and certificates of analysis. As a professional chemical distributor, OYSI ensures compliance with European regulations and provides technical support for industrial customers. Contact OYSI directly for availability, specifications, and pricing information for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.