Propanoyl chloride

Propanoyl chloride is an organic compound with the molecular formula C3H5ClO and a molecular weight of 92.52 g/mol. It belongs to the acyl chloride family, characterized by the presence of a carbonyl group bonded to a chlorine atom. This colorless liquid is highly reactive and corrosive, making it an important intermediate in organic synthesis. Its CAS number is 79-03-8, and it poses significant safety hazards requiring careful handling procedures.

Propanoyl chloride is a colorless liquid at room temperature with a pungent, acrid odor typical of acyl chlorides. It has a molecular weight of 92.52 g/mol and is highly reactive with water, undergoing rapid hydrolysis to form propanoic acid and hydrogen chloride. The compound is flammable and corrosive, requiring storage under anhydrous conditions. It readily dissolves in organic solvents but reacts violently with water and alcohols.

Propanoyl chloride serves as a key intermediate in organic synthesis, particularly in pharmaceutical and fine chemical manufacturing. It is primarily used for acylation reactions to introduce propanoyl groups into organic molecules, facilitating the synthesis of esters, amides, and other derivatives. The compound finds applications in the production of pharmaceuticals, agrochemicals, and specialty chemicals. Its high reactivity makes it valuable for creating carbon-carbon and carbon-heteroatom bonds in complex organic syntheses.

Propanoyl chloride requires strict safety measures due to its flammable and highly corrosive nature. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation of vapors. Keep away from heat sources, sparks, and open flames. Ensure emergency eyewash stations and safety showers are readily accessible. Never allow contact with water or moisture during handling.

Propanoyl chloride must be stored in tightly sealed containers under anhydrous conditions in a cool, dry, well-ventilated area away from heat sources and ignition sources. Storage temperature should remain below 25°C to maintain stability. Keep strictly separated from water, alcohols, bases, and oxidizing agents to prevent violent reactions. Use corrosion-resistant containers made of suitable materials. Storage areas should be equipped with appropriate fire suppression systems and spill containment measures.

Propanoyl chloride contact requires immediate emergency response due to its corrosive nature. For skin contact, immediately remove contaminated clothing and flush affected areas with copious amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with water for at least 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure incident.

Propanoyl chloride disposal must comply with local and international hazardous waste regulations due to its corrosive and flammable properties. Small quantities can be carefully hydrolyzed with ice water to form less hazardous propanoic acid and hydrochloric acid, which can then be neutralized. Large quantities require professional hazardous waste disposal services. Never dispose of in regular waste streams or pour down drains. Contact authorized waste management companies for proper collection and treatment according to regulatory requirements.

Propanoyl chloride is classified under ADR Class 3 (flammable liquids), Packing Group II, requiring specialized transport procedures. Packaging must meet UN specification standards for dangerous goods, using appropriate containers that resist corrosion and prevent leakage. Transport vehicles must display proper hazard placards and carry emergency response information. Drivers require ADR certification for dangerous goods transport. Shipments must include proper documentation and emergency contact information throughout the transport chain.

Propanoyl chloride is subject to various chemical regulations including REACH registration in the European Union and CLP classification requirements. It is classified as Flam. Liq. 2 and Skin Corr. 1B under CLP, requiring appropriate labeling with danger pictograms GHS02 and GHS05. The substance is not currently listed as an SVHC under REACH. Companies must comply with workplace exposure limits, transport regulations (ADR), and local environmental protection requirements when handling this chemical.

Propanoyl chloride is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across Europe. OYSI provides high-quality propanoyl chloride with proper documentation, safety data sheets, and regulatory compliance certificates. As a professional chemical distributor, OYSI ensures appropriate packaging, labeling, and transport arrangements meeting all European regulatory requirements. Contact OYSI directly for availability, technical specifications, and delivery options to your specific European location.