Propanoyl chloride

Propanoyl chloride is an organic compound with the chemical formula C3H5ClO and a molecular weight of 92.52 g/mol. It belongs to the family of acyl chlorides, which are highly reactive derivatives of carboxylic acids. This colorless liquid is characterized by its pungent odor and high reactivity with water and alcohols. Propanoyl chloride is classified as a flammable liquid and corrosive substance, requiring careful handling in industrial applications.

Propanoyl chloride is a colorless liquid with a sharp, pungent odor typical of acyl chlorides. It has a molecular formula of C3H5ClO and a molecular weight of 92.52 g/mol. The compound is highly reactive with water, undergoing rapid hydrolysis to form propanoic acid and hydrogen chloride gas. It is soluble in organic solvents but reacts violently with protic solvents like water and alcohols.

Propanoyl chloride is primarily used as an acylating agent in organic synthesis for the production of esters, amides, and anhydrides. It serves as a key intermediate in pharmaceutical manufacturing, particularly in the synthesis of active pharmaceutical ingredients. The compound is also utilized in the production of specialty chemicals, agrochemicals, and as a reagent in laboratory synthesis. Its high reactivity makes it valuable for introducing propanoyl groups into organic molecules.

Propanoyl chloride requires strict safety measures due to its corrosive and flammable nature. Personnel must wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation of vapors. Avoid contact with water, alcohols, and other protic substances. Keep away from ignition sources and ensure proper grounding of equipment to prevent static discharge.

Propanoyl chloride must be stored in tightly sealed containers in a cool, dry place away from moisture and heat sources. The storage area should be well-ventilated and equipped with appropriate fire suppression systems. Keep the substance away from incompatible materials such as water, alcohols, amines, and strong bases. Storage containers should be made of compatible materials and regularly inspected for integrity. Maintain temperatures below the flash point and ensure proper labeling.

Immediate action is required in case of contact with propanoyl chloride due to its corrosive properties. For skin contact, immediately remove contaminated clothing and rinse the affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical help if breathing difficulties occur. Never induce vomiting if ingested.

Propanoyl chloride disposal must comply with local and national hazardous waste regulations due to its corrosive and flammable properties. The substance should never be poured down drains or disposed of with regular waste. Unused material should be neutralized carefully under controlled conditions by qualified personnel. Contact licensed hazardous waste disposal companies for proper collection and treatment. Contaminated containers and materials must also be disposed of as hazardous waste following regulatory requirements.

Propanoyl chloride is classified under ADR Class 3 (flammable liquids), Packing Group II, requiring specific transport regulations. The substance must be packaged in approved containers meeting UN specifications and properly labeled with appropriate hazard markings. Transport vehicles must be equipped with suitable fire extinguishing equipment and emergency response information. Drivers require ADR certification for dangerous goods transport. Proper documentation including transport documents and emergency response procedures must accompany shipments.

Propanoyl chloride is subject to various regulatory frameworks including REACH regulation in Europe, requiring registration for manufacture or import above certain tonnages. Under CLP regulation, it must be classified and labeled with appropriate hazard pictogrammes (GHS02, GHS05) and the danger signal word. The substance is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational health and safety regulations and may need specific permits for handling and storage.

Propanoyl chloride is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across Europe. OYSI provides high-quality propanoyl chloride with proper documentation, safety data sheets, and regulatory compliance support. As a professional chemical distributor, OYSI ensures reliable supply chains and technical expertise for industrial applications. Contact OYSI directly for availability, specifications, and pricing information tailored to your specific requirements and location within Europe.