Propane-1,2-diamine

C3H10N2

propane-1,2-diamine

CAS78-90-0
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
78-90-0
EC Number
201-155-9
UN Number
2258
Index Number
612-100-00-7
PubChem CID
6567

Physical-chemical properties

Molecular Formula
C3H10N2
Molar Mass
74.13 g/mol
IUPAC Name
propane-1,2-diamine

Chemical Identifiers

InChI
InChI=1S/C3H10N2/c1-3(5)2-4/h3H,2,4-5H2,1H3
InChI Key
AOHJOMMDDJHIJH-UHFFFAOYSA-N

Overview

Propane-1,2-diamine (CAS 78-90-0) is an aliphatic diamine compound characterized by high reactivity and strong alkaline properties. This primary diamine, also known by its IUPAC designation propane-1,2-diamine, represents a versatile building block in industrial chemistry with the molecular formula C3H10N2 and a molecular weight of 74.13 g/mol. The compound features two amino groups positioned on adjacent carbon atoms of a three-carbon chain, conferring distinct chemical reactivity patterns that make it valuable for various synthetic applications. Its structural similarity to ethane-1,2-diamine places it within the important class of alkyl diamines used extensively in polymer chemistry and materials science. The substance exhibits significant safety considerations, classified under multiple hazard categories including Flammable Liquid Category 3, Acute Toxicity Category 4, and Skin Corrosion Category 1A. These classifications necessitate careful handling protocols, as indicated by the Danger signal word and associated GHS pictograms GHS02, GHS07, and GHS05. The ADR Class 8 designation reflects its corrosive nature during transportation, requiring specialized packaging and handling procedures. In industrial applications, propane-1,2-diamine serves primarily as an intermediate in pharmaceutical synthesis, where its diamine functionality enables the formation of complex heterocyclic structures. The compound also finds use in specialty polymer production, particularly in the manufacture of polyamides and epoxy curing agents. Additionally, it functions as a chelating agent in metal processing applications, similar to other diamine compounds like 2-(diethylamino)ethanol in certain coordination chemistry contexts. OYSI provides propane-1,2-diamine to European industrial customers, ensuring reliable supply chains for pharmaceutical, polymer, and specialty chemical manufacturers requiring this important diamine intermediate.

Safety & Classification

Danger
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2258
ADR Class8
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name1,2-Propylendiamin
Marine PollutantNo

Frequently Asked Questions

What is propane-1,2-diamine?

Propane-1,2-diamine is an organic chemical compound with the molecular formula C3H10N2 and CAS number 78-90-0. This diamine features two amino groups attached to a three-carbon chain, specifically at positions 1 and 2. With a molecular weight of 74.13 g/mol, it belongs to the aliphatic diamine family and serves as an important intermediate in chemical synthesis and industrial applications.

What are the physicochemical properties of propane-1,2-diamine?

Propane-1,2-diamine is typically a colorless to pale yellow liquid at room temperature with a characteristic amine-like odor. The compound is highly polar due to its two amino groups, making it readily soluble in water and polar solvents. It exhibits basic properties typical of primary amines and can form hydrogen bonds, contributing to its relatively high boiling point for its molecular weight.

What is propane-1,2-diamine used for?

Propane-1,2-diamine serves as a versatile chemical intermediate in various industrial applications. It is primarily used in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The compound also finds application in the production of polymers, resins, and as a building block for creating more complex organic molecules. Its diamine structure makes it valuable in cross-linking reactions and polymer chemistry.

How to handle propane-1,2-diamine safely?

Propane-1,2-diamine requires careful handling due to its corrosive nature and toxicity classification. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation exposure. Avoid direct skin and eye contact, as the substance can cause severe burns and tissue damage due to its Skin Corr. 1A classification.

How to store propane-1,2-diamine correctly?

Propane-1,2-diamine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition sources due to its flammable nature (Flam. Liq. 3). Keep away from acids, oxidizing agents, and other incompatible materials. Store in original containers with proper labeling and ensure adequate secondary containment to prevent spills and environmental contamination.

What to do in case of contact with propane-1,2-diamine?

Propane-1,2-diamine contact requires immediate action due to its corrosive properties. For skin contact, immediately remove contaminated clothing and flush affected area with plenty of water for at least 15 minutes. For eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move to fresh air immediately. Always consult a physician after any exposure and have safety data sheets readily available for emergency responders.

How to dispose of propane-1,2-diamine appropriately?

Propane-1,2-diamine disposal must comply with local and national hazardous waste regulations. The substance cannot be disposed of in regular waste streams due to its toxic and corrosive properties. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never pour down drains or sewers, as this can cause environmental contamination and violate environmental protection laws.

How to transport propane-1,2-diamine?

Propane-1,2-diamine is classified under ADR Class 8 (corrosive substances), Packing Group II, indicating moderate danger level for transport. Proper packaging, labeling with appropriate hazard symbols (GHS02, GHS07, GHS05), and documentation are mandatory. Transport vehicles must comply with ADR regulations, and drivers require appropriate training for handling corrosive materials. Emergency response information must accompany shipments.

Is propane-1,2-diamine subject to specific regulations?

Propane-1,2-diamine is subject to various European chemical regulations including REACH registration requirements and CLP classification obligations. While not currently listed as an SVHC (Substance of Very High Concern), it must be handled according to its hazard classifications: Flam. Liq. 3, Acute Tox. 4, and Skin Corr. 1A. Suppliers must provide safety data sheets and ensure proper labeling with danger signal words and appropriate pictograms.

Where to buy propane-1,2-diamine in Europe?

Propane-1,2-diamine is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides quality chemical products with proper documentation, safety data sheets, and regulatory compliance support across European markets. As a professional chemical supplier, OYSI ensures reliable supply chains and technical support for industrial customers requiring propane-1,2-diamine for their manufacturing processes and research applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.