Propane-1,2-diamine

C3H10N2

propane-1,2-diamine

CAS78-90-0
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
78-90-0
EC Number
201-155-9
UN Number
2258
Index Number
612-100-00-7
PubChem CID
6567

Physical-chemical properties

Molecular Formula
C3H10N2
Molar Mass
74.13 g/mol
IUPAC Name
propane-1,2-diamine

Chemical Identifiers

InChI
InChI=1S/C3H10N2/c1-3(5)2-4/h3H,2,4-5H2,1H3
InChI Key
AOHJOMMDDJHIJH-UHFFFAOYSA-N

Overview

Propane-1,2-diamine (CAS 78-90-0) is an aliphatic diamine compound featuring two primary amino groups on adjacent carbon atoms. This versatile chemical intermediate, also known by its IUPAC designation propane-1,2-diamine, serves as a fundamental building block in various industrial synthesis processes. With the molecular formula C3H10N2 and a molecular weight of 74.13 g/mol, this colorless liquid exhibits typical properties of primary aliphatic amines, including strong basicity and high reactivity toward electrophilic compounds. The compound's structure, featuring amino groups on the first and second carbon atoms of a propane chain, provides unique reactivity patterns that distinguish it from other diamines such as ethane-1,2-diamine, which has a shorter carbon chain. Safety considerations are paramount when handling propane-1,2-diamine, as it carries significant hazard classifications including Flammable Liquid Category 3, Acute Toxicity Category 4, and Skin Corrosion Category 1A. The substance requires careful handling procedures and appropriate personal protective equipment, as indicated by its "Danger" signal word and multiple GHS pictograms (GHS02, GHS07, GHS05). Its ADR classification as Class 8 reflects its corrosive nature during transportation. Industrial applications of propane-1,2-diamine primarily focus on polymer synthesis, where it functions as a curing agent for epoxy resins and as a chain extender in polyurethane production. The compound also serves in pharmaceutical intermediate synthesis and specialty chemical manufacturing. Its reactivity profile makes it valuable in producing chelating agents and corrosion inhibitors. OYSI maintains reliable supplies of propane-1,2-diamine to support diverse industrial applications across European markets, ensuring consistent quality and regulatory compliance for technical applications.

Safety & Classification

Danger
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2258
ADR Class8
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name1,2-Propylendiamin
Marine PollutantNo

Frequently Asked Questions

What is propane-1,2-diamine?

Propane-1,2-diamine is an organic chemical compound with the molecular formula C3H10N2 and CAS number 78-90-0. This diamine features two amino groups attached to a three-carbon chain, specifically at positions 1 and 2. With a molecular weight of 74.13 g/mol, it belongs to the aliphatic diamine family and serves as an important building block in various chemical syntheses and industrial applications.

What are the physicochemical properties of propane-1,2-diamine?

Propane-1,2-diamine is typically a colorless to pale yellow liquid at room temperature with a characteristic amine odor. As a polar compound containing two amino groups, it exhibits high water solubility and can form hydrogen bonds. The compound has basic properties due to its amino groups and can readily react with acids to form salts. Its diamine structure makes it highly reactive and suitable for polymerization reactions.

What is propane-1,2-diamine used for?

Propane-1,2-diamine serves as a crucial intermediate in chemical synthesis, particularly in the production of pharmaceuticals, agrochemicals, and specialty chemicals. It is commonly used as a building block for synthesizing various nitrogen-containing compounds, including chelating agents, corrosion inhibitors, and polymer precursors. The compound also finds applications in epoxy curing systems and as a cross-linking agent in polymer chemistry.

How to handle propane-1,2-diamine safely?

Propane-1,2-diamine requires careful handling due to its corrosive nature (Skin Corr. 1A) and acute toxicity. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. Due to its flammable properties (Flam. Liq. 3), keep away from ignition sources and ensure proper grounding of equipment.

How to store propane-1,2-diamine correctly?

Propane-1,2-diamine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition points. Storage areas must be equipped with appropriate fire suppression systems due to its flammable classification. Keep containers away from incompatible materials such as strong acids and oxidizing agents. Ensure storage temperatures remain stable and avoid exposure to direct sunlight or extreme temperature fluctuations.

What to do in case of contact with propane-1,2-diamine?

Immediate action is critical due to the corrosive nature of propane-1,2-diamine. For skin contact, immediately remove contaminated clothing and flush the affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek medical help immediately.

How to dispose of propane-1,2-diamine properly?

Propane-1,2-diamine disposal must comply with local and European waste regulations as it is classified as hazardous waste. The compound should never be disposed of down drains or into the environment. Proper disposal involves collection by licensed hazardous waste contractors who can ensure appropriate treatment or incineration at authorized facilities. Containers must be properly labeled and handled according to ADR transport regulations during disposal transport.

How to transport propane-1,2-diamine?

Propane-1,2-diamine is classified under ADR Class 8 (corrosive substances), Packing Group II, indicating moderate danger level during transport. Transportation requires specialized packaging that meets UN specification requirements and proper hazard labeling with corrosive substance markings. Vehicles must carry appropriate emergency equipment and drivers need ADR certification. Documentation including safety data sheets and transport documents must accompany shipments throughout the European transport network.

Is propane-1,2-diamine subject to specific regulations?

Propane-1,2-diamine is subject to European REACH regulation requiring registration for commercial use and CLP regulation for classification and labeling. While not currently listed as an SVHC (Substance of Very High Concern), its corrosive and toxic properties mean it falls under strict handling and workplace safety regulations. Users must maintain safety data sheets, implement proper risk management measures, and comply with occupational exposure limits where established.

Where to buy propane-1,2-diamine in Europe?

Propane-1,2-diamine is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI can provide this compound with proper documentation, safety data sheets, and regulatory compliance support. Their European distribution network ensures reliable supply chains while maintaining the strict quality and safety standards required for this regulated chemical substance. Contact OYSI directly for availability and technical specifications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.