Morpholine

C4H9NO

morpholine

CAS110-91-8
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
110-91-8
EC Number
203-815-1
UN Number
2054
Index Number
613-028-00-9
PubChem CID
8083

Physical-chemical properties

Molecular Formula
C4H9NO
Molar Mass
87.12 g/mol
IUPAC Name
morpholine

Chemical Identifiers

InChI
InChI=1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2
InChI Key
YNAVUWVOSKDBBP-UHFFFAOYSA-N

Overview

Morpholine (CAS 110-91-8) is a heterocyclic organic compound featuring both amine and ether functionalities within a six-membered saturated ring structure. This versatile chemical intermediate serves as a fundamental building block in numerous industrial applications due to its unique dual functionality combining amine basicity with ether stability. With the molecular formula C4H9NO and a molecular weight of 87.12 g/mol, morpholine exhibits excellent solubility in both water and organic solvents, making it highly valuable for diverse chemical processes. The compound appears as a colorless liquid with a characteristic amine-like odor and demonstrates significant reactivity through its nitrogen atom while maintaining structural integrity via its cyclic ether framework. From a safety perspective, morpholine requires careful handling as it carries multiple hazard classifications including flammable liquid category 3, acute toxicity category 4, and skin corrosion category 1B. The substance displays corrosive properties that can cause severe skin and eye damage, necessitating appropriate personal protective equipment and engineering controls during industrial use. Its flammable nature requires proper storage away from ignition sources and adequate ventilation systems. Morpholine finds extensive application as a corrosion inhibitor in boiler water treatment systems, where it effectively neutralizes carbonic acid and provides film-forming protection for metal surfaces. The pharmaceutical industry utilizes morpholine as a key intermediate in drug synthesis, while the rubber industry employs it as a vulcanization accelerator. Its chemical similarity to compounds like 2-(diethylamino)ethanol makes it particularly valuable in specialized formulations requiring controlled basicity and solubility characteristics. OYSI maintains reliable supply chains for morpholine to support diverse industrial requirements across European markets.

Safety & Classification

Danger
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2054
ADR Class8
Packing GroupI
Tunnel CodeD/E
Proper Shipping NameMorpholin
Marine PollutantNo

Frequently Asked Questions

What is morpholine?

Morpholine is an organic heterocyclic compound with the molecular formula C4H9NO and CAS number 110-91-8. It is a six-membered ring containing both oxygen and nitrogen atoms, making it both an ether and an amine. With a molecular weight of 87.12 g/mol, morpholine serves as an important building block in chemical synthesis and industrial applications due to its dual functional nature.

What are the physicochemical properties of morpholine?

Morpholine is a colorless liquid with a characteristic ammonia-like odor at room temperature. It is highly soluble in water and most organic solvents due to its polar nature and hydrogen bonding capability. The compound is hygroscopic, meaning it readily absorbs moisture from air. Its dual ether-amine structure gives it unique solvent properties and makes it miscible with both polar and non-polar substances.

What is morpholine used for?

Morpholine is primarily used as a corrosion inhibitor in steam boiler systems and as a pH adjuster in water treatment applications. It serves as an important intermediate in pharmaceutical synthesis, rubber processing, and textile treatment. The compound is also utilized in the production of optical brighteners, antioxidants, and various specialty chemicals. Its buffering properties make it valuable in analytical chemistry applications.

How to handle morpholine safely?

Morpholine requires careful handling due to its corrosive nature (Skin Corr. 1B) and acute toxicity. Wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation to prevent inhalation exposure. Avoid skin and eye contact completely. Work in a well-ventilated area or fume hood, keep away from ignition sources due to its flammable properties, and have emergency shower facilities readily available.

How to store morpholine correctly?

Morpholine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers upright and properly labeled according to CLP regulations. Store away from strong acids, oxidizing agents, and reactive metals. Maintain storage temperature below 25°C when possible and ensure storage areas have appropriate spill containment measures and fire suppression systems.

What to do in case of contact with morpholine?

Immediate action is required due to morpholine's corrosive properties. For skin contact, remove contaminated clothing and flush affected area with copious amounts of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention while providing safety data sheet to medical personnel.

How to dispose of morpholine appropriately?

Morpholine disposal must comply with local and European waste regulations as it is classified as hazardous waste. Never discharge into sewers, waterways, or soil. Small quantities should be collected in appropriate containers and disposed of through licensed hazardous waste disposal companies. Large quantities may require specialized treatment or incineration at authorized facilities. Always consult local environmental authorities and follow waste classification codes for proper disposal documentation.

How to transport morpholine?

Morpholine is classified as ADR Class 8 (corrosive substances), Packing Group I, indicating high danger level. Transportation requires UN-approved packaging and proper hazard labeling with corrosive and flammable pictograms. Vehicles must carry appropriate emergency equipment and drivers need ADR certification. Shipping documents must include proper shipping name, UN number, and emergency response information. Ensure compliance with international transport regulations for dangerous goods.

Is morpholine subject to specific regulations?

Morpholine is regulated under REACH and CLP regulations in Europe, requiring registration and proper classification labeling. It is not currently listed as a SVHC (Substance of Very High Concern). Users must comply with occupational exposure limits and workplace safety regulations. Industrial users may need to conduct chemical safety assessments and implement risk management measures. Always check current regulatory status as requirements may change.

Where to buy morpholine in Europe?

Morpholine is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides morpholine with proper documentation, safety data sheets, and regulatory compliance certificates required for European markets. As a professional chemical distributor, OYSI ensures product quality, proper packaging, and adherence to transportation regulations. Contact OYSI directly for availability, specifications, and delivery options across European markets for your morpholine requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.