Morpholine

C4H9NO

morpholine

CAS110-91-8
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
110-91-8
EC Number
203-815-1
UN Number
2054
Index Number
613-028-00-9
PubChem CID
8083

Physical-chemical properties

Molecular Formula
C4H9NO
Molar Mass
87.12 g/mol
IUPAC Name
morpholine

Chemical Identifiers

InChI
InChI=1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2
InChI Key
YNAVUWVOSKDBBP-UHFFFAOYSA-N

Overview

Morpholine (CAS 110-91-8) is a heterocyclic organic compound featuring both amine and ether functional groups in a six-membered ring structure. This versatile chemical intermediate belongs to the saturated heterocycle family and serves as a crucial building block in numerous industrial applications. With its molecular formula C4H9NO and molar mass of 87.12 g/mol, morpholine exhibits unique properties due to its dual nitrogen-oxygen ring structure, which combines the characteristics of both ethers and secondary amines. The compound presents as a colorless liquid with a characteristic amine-like odor and demonstrates good solubility in both water and organic solvents. However, morpholine requires careful handling due to its classification under multiple hazard categories. It is classified as a flammable liquid (Category 3) and exhibits acute toxicity (Category 4) through multiple exposure routes. Most notably, it is categorized as a skin corrosive substance (Category 1B), necessitating appropriate personal protective equipment and safety protocols during handling and storage. From a safety perspective, morpholine displays pictograms GHS02, GHS07, and GHS05, with "Danger" as the signal word. Its ADR classification as Class 8 indicates its corrosive nature for transportation purposes. These safety considerations make proper storage, handling procedures, and worker training essential for industrial applications. Morpholine finds extensive use in the production of rubber accelerators, corrosion inhibitors, and optical brightening agents. It also serves as an important intermediate in pharmaceutical synthesis and acts as a solvent in various chemical processes. Like related compounds such as 2-(diethylamino)ethanol, morpholine's amine functionality makes it valuable in creating specialized chemical formulations. OYSI provides high-quality morpholine to support diverse industrial applications across European markets.

Safety & Classification

Danger
Classification:

Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2054
ADR Class8
Packing GroupI
Tunnel CodeD/E
Proper Shipping NameMorpholin
Marine PollutantNo

Frequently Asked Questions

What is morpholine?

Morpholine is an organic chemical compound with the molecular formula C4H9NO and a molecular weight of 87.12 g/mol. It belongs to the heterocyclic amine family, containing both nitrogen and oxygen atoms in its six-membered ring structure. This versatile chemical intermediate is widely used in industrial applications and is classified as a corrosive and flammable liquid with acute toxicity properties.

What are the physicochemical properties of morpholine?

Morpholine is a colorless liquid with a characteristic amine-like odor at room temperature. It is highly soluble in water and most organic solvents due to its polar nature. The compound has both amine and ether functional groups, making it amphiphilic. It exhibits basic properties due to the nitrogen atom and has a relatively low molecular weight of 87.12 g/mol, contributing to its volatility and miscibility characteristics.

What is morpholine used for?

Morpholine is primarily used as a chemical intermediate in the production of rubber additives, corrosion inhibitors, and optical brighteners. It serves as a building block for pharmaceuticals, agrochemicals, and specialty chemicals. The compound is also utilized in metalworking fluids, boiler water treatment, and as a solvent for resins and dyes. Its dual amine-ether functionality makes it valuable in various industrial synthesis processes.

How to handle morpholine safely?

Morpholine requires careful handling due to its corrosive and toxic properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Avoid contact with skin, eyes, and clothing. Keep away from heat sources, sparks, and open flames due to its flammable nature. Use only non-sparking tools and equipment.

How to store morpholine correctly?

Morpholine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition sources. The storage area must be equipped with appropriate fire suppression systems. Keep containers away from incompatible materials such as strong acids, oxidizing agents, and reactive metals. Storage temperature should be controlled to prevent vapor buildup, and containers should be grounded to prevent static electricity accumulation.

What to do in case of contact with morpholine?

Morpholine contact requires immediate action due to its corrosive properties. For skin contact, immediately flush with plenty of water for at least 15 minutes and remove contaminated clothing. For eye contact, rinse thoroughly with water for at least 15 minutes and seek immediate medical attention. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure.

How to dispose of morpholine properly?

Morpholine disposal must comply with local, national, and international environmental regulations. The substance cannot be disposed of in regular waste streams due to its hazardous classification. Disposal should be carried out through licensed hazardous waste disposal facilities. Container residues require proper treatment before disposal. Incineration at approved facilities under controlled conditions is typically the preferred method, ensuring complete destruction while preventing environmental contamination.

How to transport morpholine?

Morpholine is classified as ADR Class 8 (corrosive substances), Packaging Group I, indicating high danger level during transport. Transportation requires UN-approved packaging and proper hazardous goods documentation. Vehicles must carry appropriate emergency equipment and placarding. Drivers need ADR certification for dangerous goods transport. The substance must be segregated from incompatible materials during transport and protected from temperature extremes and physical damage.

Is morpholine subject to specific regulations?

Morpholine is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification obligations. The substance is classified with multiple hazard classes: Flammable Liquid Category 3, Acute Toxicity Category 4, and Skin Corrosion Category 1B. It carries the 'Danger' signal word and requires specific GHS pictograms (GHS02, GHS07, GHS05). Industrial users must comply with workplace safety regulations and exposure limits.

Where to buy morpholine in Europe?

Morpholine is available through OYSI, a trusted European distributor of technical chemicals. As a specialized chemical distributor, OYSI provides morpholine to industrial customers across Europe with proper documentation and regulatory compliance. Professional buyers can contact OYSI for technical specifications, safety data sheets, and supply arrangements. The company ensures proper handling, packaging, and delivery according to ADR regulations and customer requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.