Ethylene oxide

C2H4O

ethylene oxide

CAS75-21-8
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS04 Gefahrensymbol: Unter Druck stehende Gase – Gasflasche
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
75-21-8
EC Number
200-849-9
UN Number
1040
Index Number
603-001-00-X
PubChem CID
6354

Physical-chemical properties

Molecular Formula
C2H4O
Molar Mass
44.05 g/mol
IUPAC Name
ethylene oxide

Chemical Identifiers

InChI
InChI=1S/C2H4O/c1-2-3-1/h1-2H2
InChI Key
IAYPIBMASNFSPL-UHFFFAOYSA-N

Overview

Ethylene oxide (CAS 75-21-8) is a cyclic ether compound with exceptional reactivity and sterilization properties used extensively in chemical manufacturing and medical applications. This colorless gas represents one of the most important industrial intermediates in modern chemistry, serving as a crucial building block for numerous chemical processes. With its three-membered ring structure containing an oxygen atom, ethylene oxide exhibits extraordinary reactivity due to ring strain, making it highly valuable for producing a wide range of derivatives including ethylene glycol, surfactants, and various polymers. As a highly regulated substance, ethylene oxide requires specialized handling due to its classification as a carcinogen category 1B, mutagen 1B, and reproductive toxicant 1B. The compound presents significant safety considerations as a flammable gas under pressure, necessitating strict adherence to safety protocols during storage, transportation, and use. Its acute toxicity profile demands comprehensive risk management measures in industrial applications. The primary industrial applications include ethylene glycol production for antifreeze and polyester manufacturing, synthesis of ethoxylated surfactants for detergents and personal care products, and sterilization of heat-sensitive medical devices and pharmaceutical products. Unlike simpler compounds such as carbon monoxide, ethylene oxide's unique structure enables complex chemical transformations that are essential for specialty chemical production. Due to its hazardous nature, ethylene oxide falls under ADR class 2 transportation regulations and requires specialized logistics infrastructure. The compound's versatility in chemical synthesis, combined with its sterilization efficacy, maintains its position as an indispensable industrial chemical despite stringent regulatory requirements. OYSI provides ethylene oxide to qualified industrial customers with comprehensive technical support and regulatory compliance documentation.

Safety & Classification

Danger
Classification:

Flam. Gas 1; Press. Gas; Carc. 1B; Muta. 1B; Repr. 1B; Acute Tox. 3; Acute Tox. 3; STOT SE 3; STO...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H220

Extremely flammable gas.

H350

May cause cancer.

H340

May cause genetic defects.

H331

Toxic if inhaled.

H301

Toxic if swallowed.

H335

May cause respiratory irritation.

H336

May cause drowsiness or dizziness.

H372

Causes damage to organs through prolonged or repeated exposure.

H314

Causes severe skin burns and eye damage.

H318

Causes serious eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1040
ADR Class2
Tunnel CodeB/D
Proper Shipping NameEthylenoxid, unter Druck verflüssigt
Marine PollutantNo

Frequently Asked Questions

What is ethylene oxide?

Ethylene oxide is a highly reactive organic compound with the molecular formula C2H4O and CAS number 75-21-8. This cyclic ether has a molecular weight of 44.05 g/mol and exists as a colorless gas at room temperature. It is classified as an extremely hazardous substance due to its flammable, carcinogenic, mutagenic, and reproductive toxicity properties. Ethylene oxide is one of the most important industrial chemicals used primarily as a sterilizing agent and chemical intermediate.

What are the physicochemical properties of ethylene oxide?

Ethylene oxide is a colorless gas at room temperature with a sweet, ether-like odor at low concentrations. It has a boiling point of 10.7°C and is highly soluble in water and most organic solvents. The compound is extremely flammable with a wide explosive range and low ignition energy. As a pressurized gas, it requires special handling equipment. Its high reactivity makes it unstable and prone to polymerization, especially in the presence of acids, bases, or elevated temperatures.

What is ethylene oxide used for?

Ethylene oxide is primarily used as a sterilizing agent for medical devices, pharmaceuticals, and heat-sensitive equipment that cannot withstand traditional steam sterilization. It serves as a key chemical intermediate in producing ethylene glycol, surfactants, and glycol ethers. The compound is also utilized in the manufacture of textiles, detergents, adhesives, and polyurethane foams. Due to its high reactivity, it's valuable in producing various specialty chemicals and as a fumigant in certain industrial applications.

How to handle ethylene oxide safely?

Ethylene oxide requires extreme safety precautions due to its multiple hazards including flammability, carcinogenicity, and acute toxicity. Personnel must wear full chemical protective suits with supplied-air respiratory protection. Work areas need explosion-proof equipment, continuous gas monitoring, and emergency ventilation systems. All ignition sources must be eliminated, and static electricity controlled. Only trained personnel should handle this substance in properly designed facilities with appropriate containment systems, leak detection, and emergency response procedures.

How to store ethylene oxide correctly?

Ethylene oxide must be stored in pressure-rated containers in cool, well-ventilated areas away from heat, ignition sources, and incompatible materials. Storage areas require explosion-proof electrical equipment, continuous gas monitoring, and emergency ventilation. The substance should be kept below 25°C and protected from direct sunlight. It's incompatible with acids, bases, metals, and oxidizing agents. Storage facilities must comply with pressure vessel regulations and have appropriate fire suppression systems designed for flammable gases.

What to do in case of contact with ethylene oxide?

Ethylene oxide exposure requires immediate emergency response due to its acute toxicity and carcinogenic properties. In case of inhalation, move the person to fresh air immediately and provide oxygen if breathing is difficult. For skin contact, remove contaminated clothing and flush with water for at least 15 minutes. Eye contact requires immediate irrigation with water for 15 minutes. Seek immediate medical attention for any exposure. Evacuate the area and eliminate ignition sources due to fire and explosion hazards.

How to dispose of ethylene oxide properly?

Ethylene oxide disposal must comply with hazardous waste regulations as it's classified as carcinogenic and highly flammable. The substance cannot be disposed of in regular waste streams and requires specialized treatment at licensed hazardous waste facilities. Small quantities may be carefully vented in well-ventilated areas away from ignition sources, following local regulations. Contaminated materials must be treated as hazardous waste. Professional waste management companies experienced with toxic and flammable gases should handle disposal operations.

How to transport ethylene oxide?

Ethylene oxide is classified under ADR Class 2 (gases) for transport and requires compliance with dangerous goods regulations. It must be shipped in approved pressure vessels designed for flammable gases, with proper labeling including GHS pictograms for flammability, pressure, carcinogenicity, and acute toxicity. Transport vehicles need appropriate placarding, emergency equipment, and trained drivers with dangerous goods certification. Shipments require proper documentation including safety data sheets and emergency response information.

Is ethylene oxide subject to specific regulations?

Ethylene oxide is heavily regulated due to its classification as carcinogenic (1B), mutagenic (1B), and toxic for reproduction (1B) under CLP regulation. It requires registration under REACH and is subject to workplace exposure limits and occupational health surveillance. Many countries have specific regulations for its use, storage, and emission control. Industrial facilities using ethylene oxide must comply with environmental permits, worker protection standards, and may require specialized ventilation and monitoring systems. Some jurisdictions restrict or prohibit certain applications.

Where to buy ethylene oxide in Europe?

Ethylene oxide is available through specialized chemical distributors like OYSI, which serves the European market with technical-grade chemicals. Due to its extremely hazardous nature and regulatory requirements, purchases are typically restricted to qualified industrial users with appropriate handling facilities and permits. Buyers must demonstrate proper storage capabilities, safety equipment, and trained personnel. The substance requires special shipping arrangements and documentation. Contact OYSI's technical team for availability, specifications, and regulatory compliance support for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.