Ethyl 2-chloroacetate

Ethyl 2-chloroacetate is an organic chemical compound with the molecular formula C4H7ClO2 and CAS number 105-39-5. This chlorinated ester has a molecular weight of 122.55 g/mol and belongs to the family of halogenated acetate esters. It is classified as a hazardous substance with acute toxicity properties and environmental concerns for aquatic organisms, requiring careful handling and storage procedures in industrial applications.

Ethyl 2-chloroacetate is typically a colorless to pale yellow liquid at room temperature with a characteristic ester odor. As an ester compound, it has limited solubility in water but is generally soluble in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of the chlorine atom affects its reactivity and makes it more polar than simple ethyl acetate, influencing its solubility profile and chemical behavior.

Ethyl 2-chloroacetate is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a building block for the production of various chemicals, including pharmaceuticals, agrochemicals, and specialty chemicals. The compound is valuable in chemical reactions where the chloroacetate group can be utilized for further functionalization, making it an important reagent in fine chemical synthesis and research applications.

Ethyl 2-chloroacetate must be handled with extreme caution due to its Acute Tox. 3 classification across multiple exposure routes. Personal protective equipment including chemical-resistant gloves, safety goggles, and appropriate respiratory protection should be worn. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion. The GHS06 pictogram indicates serious health hazards requiring strict safety protocols.

Ethyl 2-chloroacetate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. As a toxic substance, it must be kept in secure storage areas with restricted access. The container should be made of compatible materials and properly labeled according to GHS requirements. Avoid storage near oxidizing agents, strong bases, and materials that could react with chlorinated compounds.

Immediate action is required due to the acute toxicity of ethyl 2-chloroacetate. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. If inhaled, move to fresh air immediately. In case of eye contact, flush with water for 15 minutes. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult emergency services and provide the safety data sheet to medical personnel.

Ethyl 2-chloroacetate must be disposed of as hazardous waste according to local and national regulations. Due to its toxicity and environmental hazard classification (Aquatic Acute 1), it cannot be discharged into sewers or the environment. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities should be collected in appropriate containers and labeled for professional waste management services.

Ethyl 2-chloroacetate is classified under ADR Class 6.1 (toxic substances) Packing Group II, indicating significant transport restrictions. It must be packaged in UN-approved containers with proper labeling and documentation. Transportation requires compliance with dangerous goods regulations, including proper vehicle marking, driver certification, and emergency response information. Only authorized carriers experienced in hazardous materials transport should handle shipments.

Ethyl 2-chloroacetate is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification obligations. While not currently listed as an SVHC (Substance of Very High Concern), its acute toxicity classification means it falls under strict labeling, safety data sheet, and handling requirements. Users must comply with occupational safety regulations and environmental protection measures due to its aquatic toxicity classification.

Ethyl 2-chloroacetate is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI provides this regulated substance to qualified industrial customers with proper documentation and safety data sheets. Due to its hazardous classification and transport restrictions, purchase is typically limited to professional users with appropriate handling facilities and regulatory compliance capabilities.