Benzenesulfonyl chloride

Benzenesulfonyl chloride is an organic chemical compound with the molecular formula C6H5ClO2S and CAS number 98-09-9. It belongs to the family of sulfonyl chlorides, featuring a benzene ring attached to a sulfonyl chloride functional group (-SO2Cl). This compound has a molecular weight of 176.62 g/mol and serves as an important intermediate in organic synthesis and pharmaceutical manufacturing.

Benzenesulfonyl chloride is a colorless to pale yellow liquid at room temperature with a pungent, irritating odor. It has a boiling point of approximately 251°C and a density of about 1.38 g/cm³. The compound is highly reactive with water, undergoing hydrolysis to form benzenesulfonic acid and hydrochloric acid. It is soluble in organic solvents like benzene and chloroform but reacts vigorously with water and alcohols.

Benzenesulfonyl chloride is primarily used as a reagent in organic synthesis for introducing benzenesulfonyl groups into molecules. It serves as a key intermediate in pharmaceutical manufacturing, particularly in the synthesis of sulfonamide drugs and other medicinal compounds. Additionally, it is used in the production of dyes, pesticides, and various specialty chemicals. The compound is also employed in analytical chemistry for derivatization reactions and protein modification studies.

Benzenesulfonyl chloride requires careful handling due to its corrosive nature and reactivity with moisture. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in a well-ventilated area or under a fume hood to avoid inhalation of vapors. Avoid contact with water, alcohols, and other nucleophiles as this can cause violent reactions and release of toxic gases like hydrogen chloride.

Benzenesulfonyl chloride must be stored in a cool, dry place away from moisture and heat sources. Use tightly sealed containers made of compatible materials like glass or PTFE-lined vessels. Keep the chemical away from water, alcohols, amines, and other nucleophilic substances to prevent unwanted reactions. Storage areas should be well-ventilated and equipped with appropriate spill containment measures. Maintain temperatures below 25°C for optimal stability.

Benzenesulfonyl chloride contact requires immediate action due to its corrosive properties. For skin contact, immediately remove contaminated clothing and rinse affected area with copious amounts of water for at least 15 minutes. In case of eye contact, flush thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek emergency medical care. Always consult a physician after any significant exposure.

Benzenesulfonyl chloride disposal must comply with local and national hazardous waste regulations. The compound should never be poured down drains or released into the environment. Small quantities can be carefully hydrolyzed under controlled conditions to form less hazardous products, but this should only be done by trained personnel. Larger quantities require disposal through licensed hazardous waste contractors. Always consult local environmental authorities for specific disposal requirements and approved facilities.

Benzenesulfonyl chloride is classified under ADR Class 8 (Corrosive substances), Packing Group III for transportation purposes. It must be packaged in UN-approved containers suitable for corrosive liquids and properly labeled with appropriate hazard markings. Transportation requires compliance with ADR regulations including proper documentation, vehicle placarding, and driver training. Packages must be secured to prevent damage during transit and protected from temperature extremes and moisture exposure.

Benzenesulfonyl chloride is regulated under various chemical safety frameworks including REACH regulation in Europe, requiring registration for commercial use. While not classified as a Substance of Very High Concern (SVHC), it must comply with CLP regulation for classification and labeling. Users must follow standard industrial chemical handling protocols and may need to report usage depending on quantities. Always check current regulatory status and local requirements before handling or using this chemical.

Benzenesulfonyl chloride is available through specialized chemical distributors across Europe, including OYSI, a trusted European supplier of technical chemicals. OYSI provides this compound to qualified industrial and research customers with proper documentation and safety data sheets. As a regulated chemical, purchases typically require verification of intended use and appropriate handling capabilities. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements.