Benzene-1,2-diol

C6H6O2

benzene-1,2-diol

CAS120-80-9
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
Danger

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Identification

CAS Number
120-80-9
EC Number
204-427-5
UN Number
2811
Index Number
604-016-00-4
PubChem CID
289

Physical-chemical properties

Molecular Formula
C6H6O2
Molar Mass
110.11 g/mol
IUPAC Name
benzene-1,2-diol

Chemical Identifiers

InChI
InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H
InChI Key
YCIMNLLNPGFGHC-UHFFFAOYSA-N

Overview

Benzene-1,2-diol (CAS 120-80-9) is an aromatic diol compound featuring two adjacent hydroxyl groups on a benzene ring. This chemical substance, also known by its IUPAC name benzene-1,2-diol, represents a fundamental dihydroxybenzene isomer with the molecular formula C6H6O2 and a molecular weight of 110.11 g/mol. The compound is characterized by its distinctive ortho-substituted phenolic structure, where two hydroxyl groups are positioned adjacently on the benzene ring, creating unique chemical properties that distinguish it from other phenolic compounds. Benzene-1,2-diol exhibits significant chemical reactivity due to its dual hydroxyl functionality, making it valuable in various synthetic applications. However, this substance requires careful handling due to its serious health hazards. Classified with GHS pictograms GHS08 and GHS06, it carries a "Danger" signal word and is categorized as Carcinogenic 1B, Mutagenic 2, and Acute Toxic 3. The compound also presents skin and eye irritation risks, necessitating appropriate safety measures during storage, handling, and transportation under ADR Class 6.1 regulations. Industrial applications of benzene-1,2-diol span multiple sectors, including its use as an intermediate in pharmaceutical synthesis, as a precursor in polymer chemistry, and in the production of specialized chemical compounds. The substance finds particular relevance in manufacturing processes requiring ortho-dihydroxy functionality, distinguishing it from related aromatic compounds such as N-methylaniline and phenylhydrazine, which serve different industrial purposes despite sharing aromatic structural features. OYSI provides benzene-1,2-diol to European industrial customers, ensuring compliance with all relevant safety and regulatory requirements for this controlled chemical substance.

Safety & Classification

Danger
Classification:

Carc. 1B; Muta. 2; Acute Tox. 3; Acute Tox. 3; Skin Irrit. 2; Eye Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H341

Suspected of causing genetic defects.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H315

Causes skin irritation.

H319

Causes serious eye irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameBrenzcatechin, fest
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,2-diol?

Benzene-1,2-diol is an organic compound with the molecular formula C6H6O2 and CAS number 120-80-9. Also known as catechol or pyrocatechol, it consists of a benzene ring with two adjacent hydroxyl groups. With a molecular weight of 110.11 g/mol, this aromatic diol appears as white crystals that darken upon exposure to air and light. It is classified as a dangerous substance due to its carcinogenic, mutagenic, and toxic properties.

What are the physicochemical properties of benzene-1,2-diol?

Benzene-1,2-diol is a white crystalline solid at room temperature that tends to darken when exposed to air and light due to oxidation. It has a melting point of approximately 105°C and is highly soluble in water, alcohol, and ether. The compound exhibits a characteristic phenolic odor and is sensitive to oxidation. Its aromatic structure with two hydroxyl groups makes it a strong reducing agent and highly reactive towards various chemical reagents.

What is benzene-1,2-diol used for?

Benzene-1,2-diol serves as an important intermediate in chemical synthesis, particularly in the production of pesticides, pharmaceuticals, and antioxidants. It is used in the manufacture of various industrial compounds including flavoring agents, photographic developers, and rubber antioxidants. The compound also finds applications in the synthesis of specialty chemicals and serves as a precursor for other catechol derivatives used in industrial processes.

How to handle benzene-1,2-diol safely?

Benzene-1,2-diol requires careful handling due to its carcinogenic and mutagenic properties. Personal protective equipment must include chemical-resistant gloves, safety goggles, and respiratory protection when handling powders or in poorly ventilated areas. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin and eye contact, inhalation, and ingestion. Emergency washing facilities should be readily available, and all handling procedures should follow strict safety protocols.

How to store benzene-1,2-diol correctly?

Benzene-1,2-diol should be stored in tightly sealed containers in a cool, dry, and dark place to prevent oxidation and discoloration. The storage area must be well-ventilated and away from heat sources, oxidizing agents, and incompatible materials. Containers should be made of suitable materials and properly labeled according to GHS requirements. Access should be restricted to authorized personnel only, and storage conditions should comply with local safety regulations for carcinogenic substances.

What to do in case of contact with benzene-1,2-diol?

In case of skin contact with benzene-1,2-diol, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. If ingested, do not induce vomiting and seek immediate medical attention. Always consult a physician after any significant exposure.

How to dispose of benzene-1,2-diol appropriately?

Benzene-1,2-diol must be disposed of as hazardous waste according to local and national regulations due to its carcinogenic properties. It cannot be disposed of in regular waste streams or poured down drains. Contact licensed hazardous waste disposal companies for proper collection and treatment. Containers must be properly labeled and documented for waste tracking. Disposal methods typically involve high-temperature incineration at authorized facilities equipped to handle toxic and carcinogenic substances.

How to transport benzene-1,2-diol?

Benzene-1,2-diol is classified under ADR as Class 6.1 (toxic substances), Packing Group III, requiring specific packaging and labeling for transport. Packages must bear appropriate hazard labels including GHS06 and GHS08 pictograms with the signal word 'Danger'. Transportation documents must include proper shipping names and hazard identification numbers. Only certified carriers experienced in handling toxic chemicals should transport this substance, following all applicable dangerous goods regulations.

Is benzene-1,2-diol subject to specific regulations?

Benzene-1,2-diol is subject to stringent regulations under REACH and CLP due to its classification as carcinogenic (Category 1B) and mutagenic (Category 2). It requires safety data sheets, hazard communication, and specific risk management measures. While not currently listed as a Substance of Very High Concern (SVHC), its dangerous properties require compliance with occupational exposure limits and worker protection regulations. Users must implement appropriate risk management measures and ensure regulatory compliance.

Where to buy benzene-1,2-diol in Europe?

Benzene-1,2-diol is available through OYSI, a specialized European distributor of chemical products. As an established supplier, OYSI provides this regulated substance to qualified industrial customers with proper documentation and safety data sheets. Due to the substance's hazardous classification, purchases typically require verification of intended use and appropriate handling capabilities. Contact OYSI directly for availability, specifications, and regulatory compliance documentation required for your specific application and location.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.