Azepan-2-one

Azepan-2-one is a seven-membered cyclic lactam with the molecular formula C6H11NO and CAS number 105-60-2. This organic compound has a molecular weight of 113.16 g/mol and belongs to the lactam family of chemicals. It features a heterocyclic ring structure containing both carbon and nitrogen atoms, with a ketone functional group. Azepan-2-one is classified as hazardous with acute toxicity and irritant properties, requiring appropriate safety measures during handling and use.

Azepan-2-one is typically a colorless to pale yellow liquid or crystalline solid at room temperature, depending on purity and conditions. It exhibits good solubility in polar solvents due to its lactam structure and polar carbonyl group. The compound has a characteristic mild odor and is hygroscopic, meaning it can absorb moisture from air. Its seven-membered ring structure provides specific chemical reactivity patterns typical of medium-ring lactams, making it useful in various synthetic applications.

Azepan-2-one serves primarily as an intermediate in pharmaceutical synthesis and polymer chemistry. It is commonly used in the production of polyamides and as a building block for various drug compounds. The substance finds applications in specialty chemical manufacturing, particularly in the synthesis of complex organic molecules. Its lactam structure makes it valuable for creating nitrogen-containing heterocycles and as a precursor for ring-opening polymerization reactions in industrial processes.

Azepan-2-one requires careful handling due to its acute toxicity and irritant properties (GHS07 pictogram). Essential PPE includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work in well-ventilated areas or under fume hoods to avoid inhalation exposure. The substance carries a Warning signal word and requires adherence to STOT SE 3 precautions. Always wash hands thoroughly after handling and avoid eating, drinking, or smoking in work areas.

Azepan-2-one should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers properly labeled and segregated from incompatible materials. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures to prevent degradation. Ensure storage complies with local regulations for hazardous chemicals and implement proper inventory management to track quantities and expiration dates.

Azepan-2-one exposure requires immediate first aid due to its skin and eye irritant properties. For skin contact, immediately remove contaminated clothing and wash affected area with plenty of soap and water for at least 15 minutes. In case of eye contact, flush with clean water for 15-20 minutes and remove contact lenses if present. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention. Always consult medical professionals for any exposure incident.

Azepan-2-one disposal must comply with local and national hazardous waste regulations due to its toxicity classification. The substance cannot be disposed of through regular waste streams and requires specialized hazardous waste treatment. Contact licensed waste management companies for proper collection and disposal. Small quantities may be suitable for incineration at high temperatures in approved facilities. Never discharge into sewers, waterways, or soil. Maintain proper documentation of all disposal activities as required by regulations.

Azepan-2-one transport requirements depend on quantity and packaging specifications, though specific ADR classification details are not assigned for this substance. Standard chemical shipping protocols apply, including proper labeling with hazard information and GHS07 pictogram. Use appropriate packaging materials compatible with the substance and ensure containers are securely sealed and labeled. Transport should comply with general dangerous goods regulations, and carriers must be informed of the chemical's hazardous properties including acute toxicity and irritant characteristics.

Azepan-2-one is subject to standard chemical regulations including REACH registration requirements in Europe and CLP classification for hazard communication. The substance is not currently listed as an SVHC (Substance of Very High Concern) under REACH. However, its acute toxicity and irritant properties require compliance with workplace safety regulations and proper hazard communication through safety data sheets. Users must implement appropriate risk management measures and ensure worker protection according to occupational health and safety legislation.

Azepan-2-one is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers. OYSI provides quality-assured chemical products with proper documentation including safety data sheets and certificates of analysis. As a professional chemical supplier, OYSI ensures compliance with European regulations and offers technical support for customers requiring azepan-2-one for pharmaceutical synthesis, polymer chemistry, or other industrial applications. Contact OYSI directly for availability, specifications, and pricing information.