4-tert-butylphenol

C10H14O

CAS98-54-4
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
98-54-4
EC Number
202-679-0
UN Number
3077
Index Number
604-090-00-8
PubChem CID
7393

Physical-chemical properties

Molecular Formula
C10H14O
Molar Mass
150.22 g/mol
IUPAC Name
4-tert-butylphenol

Chemical Identifiers

InChI
InChI=1S/C10H14O/c1-10(2,3)8-4-6-9(11)7-5-8/h4-7,11H,1-3H3
InChI Key
QHPQWRBYOIRBIT-UHFFFAOYSA-N

Overview

4-tert-butylphenol (CAS 98-54-4) is an alkylated phenolic compound with antioxidant properties and endocrine-disrupting potential. This organic chemical belongs to the family of substituted phenols, characterized by a tert-butyl group attached to the para position of the phenol ring. With the molecular formula C10H14O and a molecular weight of 150.22 g/mol, 4-tert-butylphenol appears as a white to pale yellow crystalline solid at room temperature. The compound is classified under European CLP regulation with significant hazard classifications including reproductive toxicity (Repr. 2), skin irritation (Skin Irrit. 2), serious eye damage (Eye Dam. 1), and chronic aquatic toxicity (Aquatic Chronic 1), requiring careful handling protocols. The substance exhibits typical phenolic reactivity due to its hydroxyl group, while the bulky tert-butyl substituent provides steric hindrance that influences its chemical behavior and applications. Like other phenolic compounds such as benzene-1,4-diol, it demonstrates antioxidant properties, though its specific molecular structure confers distinct characteristics. The compound requires transport classification as Class 9 miscellaneous dangerous goods under ADR regulations. Primary industrial applications include its use as an intermediate in polymer production, particularly in the manufacture of phenolic resins and as a stabilizer in various polymer formulations. It also serves as a precursor for antioxidant compounds and finds application in specialty chemical synthesis. The compound's phenolic structure makes it valuable in applications requiring controlled reactivity and stability enhancement. OYSI provides 4-tert-butylphenol to European industrial customers, ensuring compliance with REACH regulations and maintaining high quality standards for technical applications.

Safety & Classification

Danger
Classification:

Repr. 2; Skin Irrit. 2; Eye Dam. 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H315

Causes skin irritation.

H318

Causes serious eye damage.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name4-tert-Butylphenol, fest
Marine PollutantNo

Frequently Asked Questions

What is 4-tert-butylphenol?

4-tert-butylphenol is an organic chemical compound with the molecular formula C10H14O and CAS number 98-54-4. It belongs to the phenol family, characterized by a hydroxyl group attached to a benzene ring with a tert-butyl substituent at the para position. With a molecular weight of 150.22 g/mol, this substance is classified as hazardous with reproductive toxicity concerns, skin and eye irritation properties, and aquatic toxicity.

What are the physicochemical properties of 4-tert-butylphenol?

4-tert-butylphenol is typically a white to pale yellow crystalline solid at room temperature with a characteristic phenolic odor. It has moderate solubility in water but dissolves readily in organic solvents such as alcohols, ethers, and aromatic hydrocarbons. The compound exhibits typical phenolic properties including acidic behavior due to the hydroxyl group and susceptibility to oxidation under certain conditions.

What is 4-tert-butylphenol used for?

4-tert-butylphenol is primarily used as an intermediate in the production of antioxidants, particularly for rubber and plastic applications. It serves as a precursor for manufacturing butylated hydroxytoluene (BHT) and other phenolic antioxidants. Additionally, it finds applications in the synthesis of resins, adhesives, and specialty chemicals. The compound is also utilized in research and development activities within the chemical industry.

How to handle 4-tert-butylphenol safely?

4-tert-butylphenol requires careful handling due to its hazardous classification including reproductive toxicity and irritant properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles or face shield, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume hoods. Avoid inhalation of dust or vapors, and prevent contact with eyes and skin. Emergency eyewash stations and safety showers should be readily accessible.

How to store 4-tert-butylphenol correctly?

4-tert-butylphenol should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly sealed to prevent contamination and oxidation. Store away from incompatible materials such as strong oxidizing agents and bases. The storage area should be equipped with appropriate spill containment measures and fire protection systems. Maintain temperatures below 25°C when possible to ensure product stability.

What to do in case of contact with 4-tert-butylphenol?

In case of skin contact with 4-tert-butylphenol, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention due to the eye damage classification. If inhaled, move to fresh air immediately. If swallowed, do not induce vomiting and seek immediate medical attention. Always consult a physician in case of exposure.

How to dispose of 4-tert-butylphenol properly?

4-tert-butylphenol must be disposed of according to local, national, and international hazardous waste regulations due to its environmental toxicity classification. The substance should not be released into waterways or soil due to its aquatic chronic toxicity. Contact licensed hazardous waste disposal companies for proper treatment, which may include high-temperature incineration or other approved methods. Empty containers should also be treated as hazardous waste unless properly decontaminated.

How to transport 4-tert-butylphenol?

4-tert-butylphenol is classified under ADR as Class 9 (Miscellaneous dangerous goods), Packing Group III, indicating moderate transport hazard. It must be packaged in UN-approved containers with appropriate marking, labeling, and documentation. Transport vehicles require proper placarding and drivers need ADR certification. The substance should be secured to prevent spillage during transport and separated from incompatible materials. Emergency response information must accompany shipments.

Is 4-tert-butylphenol subject to special regulations?

4-tert-butylphenol is subject to various European regulations including REACH registration requirements and CLP classification for hazard communication. It must be labeled with GHS pictograms (GHS08, GHS05, GHS09) and the danger signal word due to its reproductive toxicity, corrosive, and environmental hazard properties. While not currently listed as an SVHC, it requires safety data sheets and may be subject to workplace exposure limits and environmental discharge restrictions in various EU member states.

Where to buy 4-tert-butylphenol in Europe?

4-tert-butylphenol is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides high-quality 4-tert-butylphenol with complete regulatory documentation including safety data sheets, certificates of analysis, and REACH compliance documentation. As a professional chemical distributor, OYSI ensures proper packaging, labeling, and transport arrangements throughout Europe, serving industries requiring this specialized phenolic intermediate for their manufacturing processes.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.