1,2-benzothiazol-3-one

1,2-benzothiazol-3-one is an organic heterocyclic compound with the molecular formula C7H5NOS and CAS number 2634-33-5. This benzothiazole derivative has a molecular weight of 151.19 g/mol and features a fused benzene-thiazole ring system with a ketone group at position 3. It is classified as a hazardous substance with multiple risk categories including acute toxicity, skin and eye irritation, skin sensitization, and aquatic toxicity.

1,2-benzothiazol-3-one is a solid organic compound at room temperature with a molecular weight of 151.19 g/mol. The substance contains sulfur, nitrogen, and oxygen atoms within its heterocyclic structure, giving it polar characteristics. Its benzothiazole backbone provides aromatic stability while the ketone functionality influences its reactivity. Specific physical properties such as melting point, solubility, and appearance may vary depending on purity and crystalline form.

1,2-benzothiazol-3-one serves as an important intermediate in pharmaceutical and chemical synthesis. It is commonly used in the production of various pharmaceutical compounds, particularly those requiring benzothiazole moieties. The compound also finds applications in the synthesis of dyes, pigments, and other specialty chemicals. Its heterocyclic structure makes it valuable for developing biologically active molecules and as a building block in organic synthesis processes.

1,2-benzothiazol-3-one requires careful handling due to its classification as Acute Tox. 2 and multiple hazard categories. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work in well-ventilated areas or under fume hoods to avoid inhalation. The substance is a strong skin sensitizer (Skin Sens. 1A), so preventing dermal exposure is critical. Follow strict hygiene protocols and wash hands thoroughly after handling.

1,2-benzothiazol-3-one should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers upright and properly labeled according to GHS requirements with appropriate pictograms (GHS06, GHS05, GHS09). Store separately from incompatible materials and ensure access is restricted to trained personnel only. Regular inspection of containers for damage or leaks is essential to maintain storage integrity and safety.

In case of skin contact with 1,2-benzothiazol-3-one, immediately remove contaminated clothing and wash the affected area with plenty of soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for at least 15 minutes and seek medical attention due to its Eye Dam. 1 classification. If inhaled, move to fresh air immediately. If ingested, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for specific first aid measures.

1,2-benzothiazol-3-one must be disposed of as hazardous waste through authorized waste management companies in compliance with local and European regulations. The substance cannot be disposed of in regular waste streams due to its toxicity and environmental hazard classification (Aquatic Acute 1). Container disposal should follow the same hazardous waste protocols. Incineration at licensed high-temperature facilities is typically the preferred treatment method, ensuring complete destruction while meeting emission standards.

1,2-benzothiazol-3-one is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to European transport regulations. Packages must display proper shipping names, UN numbers, and hazard labels. Transport vehicles should carry appropriate emergency response information and drivers must have ADR certification. Special handling procedures apply during loading, transport, and unloading operations.

1,2-benzothiazol-3-one is subject to European REACH regulation and CLP classification requirements. While not currently listed as an SVHC (Substance of Very High Concern), its multiple hazard classifications require compliance with occupational safety regulations and environmental protection measures. Users must maintain safety data sheets, implement appropriate risk management measures, and ensure worker protection standards are met. Import/export may require additional documentation depending on destination countries and quantities involved.

1,2-benzothiazol-3-one is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to pharmaceutical, chemical, and research industries across Europe with appropriate documentation including certificates of analysis and safety data sheets. As an established chemical distributor, OYSI ensures regulatory compliance and proper handling procedures. Contact OYSI directly for availability, technical specifications, packaging options, and delivery information for your specific requirements.