4-nitrosophenol

4-nitrosophenol is an organic chemical compound with the molecular formula C6H5NO2 and CAS number 104-91-6. It belongs to the family of nitrosophenols, characterized by the presence of both a nitroso group (-NO) and a hydroxyl group (-OH) attached to a benzene ring. With a molecular weight of 123.11 g/mol, this compound is classified as hazardous due to its mutagenic properties, acute toxicity, and potential for causing serious eye damage.

4-nitrosophenol typically appears as a crystalline solid at room temperature, often displaying a yellowish to brownish coloration due to the presence of the nitroso functional group. The compound has a molecular weight of 123.11 g/mol and contains both polar (hydroxyl and nitroso groups) and nonpolar (benzene ring) regions, affecting its solubility characteristics. Its physicochemical properties are influenced by intramolecular hydrogen bonding and the electron-withdrawing nature of the nitroso group.

4-nitrosophenol serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of dyes, pigments, and other organic compounds where the nitroso functionality is required. The compound also finds applications in analytical chemistry as a reagent for various chemical tests and reactions. Additionally, it may be employed in research settings for studying nitrosation reactions and developing new chemical processes in the pharmaceutical and chemical industries.

4-nitrosophenol requires careful handling due to its classification as Muta. 2, Acute Tox. 4, and Eye Dam. 1. Essential personal protective equipment includes chemical-resistant gloves, safety goggles or face shield, and appropriate respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin and eye contact, and ensure emergency washing facilities are readily available. All handling procedures should follow established safety protocols and risk assessments.

4-nitrosophenol should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. As a Class 4.1 substance, it requires storage conditions that prevent decomposition or unwanted reactions. Keep containers properly labeled and segregated from incompatible materials. Storage areas should be equipped with appropriate spill containment measures and emergency response equipment. Regular inspection of containers for signs of deterioration or leakage is recommended to maintain storage integrity.

Immediate action is required following contact with 4-nitrosophenol due to its Eye Dam. 1 and Acute Tox. 4 classifications. For eye contact, flush immediately with plenty of clean water for at least 15 minutes and seek medical attention urgently. In case of skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention immediately while providing the safety data sheet to medical personnel.

4-nitrosophenol disposal must comply with local and European waste regulations due to its hazardous classification including mutagenic properties and aquatic toxicity (Aquatic Chronic 2). The substance should never be disposed of down drains or into the environment. Waste should be collected in appropriate containers, properly labeled, and handed over to licensed waste disposal companies specializing in hazardous chemical waste. Incineration at authorized facilities capable of handling toxic substances is typically the preferred disposal method.

4-nitrosophenol is classified under ADR Class 4.1, indicating it is a flammable solid requiring specific transport regulations. Packaging must comply with UN packaging requirements for Class 4.1 substances, using approved containers that prevent leakage and contamination. Transport documents must include proper shipping names, hazard classes, and emergency response information. Vehicles transporting this substance should carry appropriate emergency equipment and drivers must be trained in hazardous materials transport procedures according to ADR regulations.

4-nitrosophenol is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification obligations. While not currently listed as a SVHC (Substance of Very High Concern), its Muta. 2 classification means it falls under strict regulatory oversight. Companies handling this substance must comply with worker protection regulations, environmental discharge limits, and proper classification and labeling requirements. Regular monitoring and risk assessment documentation may be required depending on usage volumes and applications.

4-nitrosophenol is available through specialized chemical distributors across Europe, with OYSI serving as a reliable European supplier for this regulated substance. As a professional chemical distributor, OYSI ensures compliance with all relevant European regulations including REACH registration and proper documentation. When sourcing 4-nitrosophenol, it's essential to work with established suppliers who provide complete safety data sheets, certificates of analysis, and regulatory compliance documentation to ensure safe and legal procurement of this hazardous material.