Trimethyl(oxiran-2-ylmethyl)azanium chloride

C6H14ClNO

trimethyl(oxiran-2-ylmethyl)azanium chloride

CAS3033-77-0
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
3033-77-0
EC Number
221-221-0
UN Number
1325
Index Number
603-211-00-1
PubChem CID
18205

Physical-chemical properties

Molecular Formula
C6H14ClNO
Molar Mass
151.63 g/mol
IUPAC Name
trimethyl(oxiran-2-ylmethyl)azanium chloride

Chemical Identifiers

InChI
InChI=1S/C6H14NO.ClH/c1-7(2,3)4-6-5-8-6;/h6H,4-5H2,1-3H3;1H/q+1;/p-1
InChI Key
PUVAFTRIIUSGLK-UHFFFAOYSA-M

Overview

Trimethyl(oxiran-2-ylmethyl)azanium chloride (CAS 3033-77-0) is a quaternary ammonium compound with epoxide functionality and significant health hazard classifications. This specialized chemical compound, also identified by EC number 221-221-0 and molecular formula C6H14ClNO, represents an important class of reactive intermediates in industrial chemistry. With a molecular weight of 151.63 g/mol, trimethyl(oxiran-2-ylmethyl)azanium chloride combines the properties of quaternary ammonium salts with the reactivity of epoxide groups, making it valuable for specific synthetic applications where both cationic charge and ring-opening reactions are required. The compound carries extensive safety warnings with GHS08, GHS07, and GHS05 pictograms, reflecting its classification as a Category 1B carcinogen, Category 2 mutagen, and Category 2 reproductive toxin. Additional hazards include acute toxicity, eye damage potential, skin sensitization, and specific target organ toxicity with repeated exposure. Its ADR classification as Class 4.1 indicates it requires careful handling as a flammable solid during transport and storage. Primary industrial applications include use as a reactive intermediate in polymer synthesis, particularly for introducing quaternary ammonium functionality into epoxy-based materials, and as a crosslinking agent in specialized coating formulations. The compound also serves in the production of antimicrobial polymers where both the epoxide reactivity and quaternary ammonium properties are essential. Unlike simpler reactive compounds such as 2-bromo-2-nitropropane-1,3-diol, this material offers unique dual functionality for advanced chemical synthesis. OYSI provides trimethyl(oxiran-2-ylmethyl)azanium chloride to qualified industrial customers with comprehensive safety documentation and regulatory compliance support throughout Europe.

Safety & Classification

Danger
Classification:

Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H341

Suspected of causing genetic defects.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H318

Causes serious eye damage.

H317

May cause an allergic skin reaction.

H412

Harmful to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1325
ADR Class4.1
Packing GroupII
Tunnel CodeE
Proper Shipping NameGlycidyltrimethylammoniumchlorid
Marine PollutantNo

Frequently Asked Questions

What is trimethyl(oxiran-2-ylmethyl)azanium chloride?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is a quaternary ammonium compound with the molecular formula C6H14ClNO and CAS number 3033-77-0. This chemical has a molecular weight of 151.63 g/mol and contains both an epoxide ring and a quaternary nitrogen center. It is classified as a hazardous substance with multiple danger classifications including carcinogenic, mutagenic, and reproductive toxicity properties, requiring careful handling in industrial applications.

What are the physicochemical properties of trimethyl(oxiran-2-ylmethyl)azanium chloride?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is a quaternary ammonium salt that typically appears as a solid or crystalline material at room temperature. As a chloride salt of a quaternary ammonium compound, it generally exhibits good water solubility due to its ionic nature. The presence of the epoxide group contributes to its reactivity, while the quaternary ammonium structure provides cationic properties typical of surfactant-like behavior.

What is trimethyl(oxiran-2-ylmethyl)azanium chloride used for?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is primarily used as a chemical intermediate in organic synthesis and as a crosslinking agent in polymer chemistry. Its epoxide functionality makes it valuable for curing reactions with amino and hydroxyl-containing compounds. The quaternary ammonium structure also provides antimicrobial properties, making it useful in specialized formulations. However, due to its hazardous classification, its applications are restricted to professional industrial uses with appropriate safety measures.

How to handle trimethyl(oxiran-2-ylmethyl)azanium chloride safely?

Trimethyl(oxiran-2-ylmethyl)azanium chloride requires strict safety protocols due to its carcinogenic, mutagenic, and eye-damaging properties. Essential PPE includes chemical-resistant gloves, safety goggles or face shield, and protective clothing. Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Avoid skin and eye contact completely. Only trained personnel should handle this substance, and emergency procedures must be readily available due to its multiple hazard classifications.

How to store trimethyl(oxiran-2-ylmethyl)azanium chloride correctly?

Trimethyl(oxiran-2-ylmethyl)azanium chloride must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Due to the reactive epoxide group, avoid contact with acids, bases, and nucleophilic compounds that could cause ring-opening reactions. Store in original, tightly sealed containers with appropriate hazard labeling. Access should be restricted to authorized personnel only, and storage areas must comply with regulations for carcinogenic substances.

What to do in case of contact with trimethyl(oxiran-2-ylmethyl)azanium chloride?

Immediate action is critical due to the substance's eye-damaging and sensitizing properties. For eye contact, flush immediately with plenty of water for at least 15 minutes and seek immediate medical attention. For skin contact, remove contaminated clothing and wash thoroughly with soap and water. If inhaled, move to fresh air immediately. Due to its carcinogenic classification, all exposure incidents require prompt medical evaluation and documentation for occupational health records.

How to dispose of trimethyl(oxiran-2-ylmethyl)azanium chloride properly?

Trimethyl(oxiran-2-ylmethyl)azanium chloride must be disposed of as hazardous waste through licensed waste management companies specializing in carcinogenic substances. Never discharge to sewers, waterways, or regular waste streams. Disposal must comply with local and EU waste regulations, particularly for Category 1B carcinogens. All containers, contaminated materials, and PPE used during handling must also be treated as hazardous waste and disposed of through appropriate channels with proper documentation.

How to transport trimethyl(oxiran-2-ylmethyl)azanium chloride?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is classified under ADR Class 4.1 (Flammable solids) with Packing Group II, indicating moderate danger level during transport. Packages must meet UN specification requirements for this classification and display appropriate hazard labels and markings. Transport must comply with ADR regulations including driver training, vehicle equipment, and routing restrictions. Shipping documents must include proper shipping names, hazard classes, and emergency response information.

Is trimethyl(oxiran-2-ylmethyl)azanium chloride subject to special regulations?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is subject to extensive EU chemical regulations under REACH and CLP due to its hazardous properties. As a Category 1B carcinogen with mutagenic and reproductive toxicity, it requires strict occupational exposure controls and may face authorization requirements. Companies must maintain safety data sheets, conduct risk assessments, and implement appropriate risk management measures. While not currently listed as SVHC, its hazard profile requires compliance with worker protection and environmental regulations.

Where to buy trimethyl(oxiran-2-ylmethyl)azanium chloride in Europe?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is available through OYSI, a specialized European distributor of technical chemicals with expertise in hazardous substances. As a professional chemical supplier, OYSI ensures proper packaging, documentation, and regulatory compliance for this controlled substance. Due to its hazardous classification, purchase is restricted to qualified industrial users who can demonstrate appropriate handling capabilities, safety measures, and legitimate business applications requiring this specific chemical intermediate.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.