Trimethyl(oxiran-2-ylmethyl)azanium chloride

C6H14ClNO

trimethyl(oxiran-2-ylmethyl)azanium chloride

CAS3033-77-0
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
3033-77-0
EC Number
221-221-0
UN Number
1325
Index Number
603-211-00-1
PubChem CID
18205

Physical-chemical properties

Molecular Formula
C6H14ClNO
Molar Mass
151.63 g/mol
IUPAC Name
trimethyl(oxiran-2-ylmethyl)azanium chloride

Chemical Identifiers

InChI
InChI=1S/C6H14NO.ClH/c1-7(2,3)4-6-5-8-6;/h6H,4-5H2,1-3H3;1H/q+1;/p-1
InChI Key
PUVAFTRIIUSGLK-UHFFFAOYSA-M

Overview

Trimethyl(oxiran-2-ylmethyl)azanium chloride (CAS 3033-77-0) is a quaternary ammonium compound with epoxide functionality and significant toxicological hazards. This specialized chemical intermediate represents a unique class of bifunctional compounds that combine the reactivity of epoxide groups with the stability of quaternary ammonium salts. With the molecular formula C6H14ClNO and a molecular weight of 151.63 g/mol, this compound exhibits dual chemical reactivity patterns that make it valuable for specific industrial applications requiring both cationic character and ring-opening potential. The compound presents significant safety considerations, classified under multiple hazard categories including carcinogenicity (Category 1B), mutagenicity (Category 2), and reproductive toxicity (Category 2). Additional acute toxicity concerns and potential for serious eye damage necessitate strict handling protocols and appropriate personal protective equipment. The ADR classification 4.1 indicates its status as a flammable solid requiring specialized transport conditions. From a chemical perspective, the oxirane ring provides nucleophilic attack sites, while the quaternary ammonium group offers cationic functionality for various chemical transformations. This dual nature distinguishes it from simpler compounds like 4-nitrosophenol, which lacks the quaternary ammonium character. The compound's structure enables participation in ring-opening polymerization reactions and quaternary ammonium-mediated processes. Primary industrial applications include use as a chemical intermediate in polymer synthesis, particularly in the production of specialty resins and cross-linking agents. It also finds application in the manufacture of cationic surfactants and as a reactive component in epoxy-based formulations. OYSI maintains availability of trimethyl(oxiran-2-ylmethyl)azanium chloride for qualified industrial customers requiring this specialized chemical intermediate for their manufacturing processes.

Safety & Classification

Danger
Classification:

Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H341

Suspected of causing genetic defects.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H318

Causes serious eye damage.

H317

May cause an allergic skin reaction.

H412

Harmful to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1325
ADR Class4.1
Packing GroupII
Tunnel CodeE
Proper Shipping NameGlycidyltrimethylammoniumchlorid
Marine PollutantNo

Frequently Asked Questions

What is trimethyl(oxiran-2-ylmethyl)azanium chloride?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is a quaternary ammonium compound with the molecular formula C6H14ClNO and CAS number 3033-77-0. This chemical has a molecular weight of 151.63 g/mol and contains an epoxide (oxirane) ring attached to a trimethylammonium group. It is classified as a hazardous substance with multiple health concerns including carcinogenic, mutagenic, and reproductive toxicity properties, requiring careful handling and specialized safety protocols in industrial applications.

What are the physicochemical properties of trimethyl(oxiran-2-ylmethyl)azanium chloride?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is a quaternary ammonium salt that typically appears as a solid or crystalline material at room temperature. As an ionic compound containing both hydrophilic quaternary ammonium and chloride components, it generally exhibits good water solubility. The presence of the epoxide ring makes it reactive towards nucleophiles. Due to its quaternary ammonium structure, it likely has surface-active properties and can act as a cationic surfactant in aqueous solutions.

What is trimethyl(oxiran-2-ylmethyl)azanium chloride used for?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is primarily used as a chemical intermediate in organic synthesis and polymer chemistry. Its epoxide functionality makes it valuable for crosslinking reactions and as a reactive monomer in polymer production. The quaternary ammonium structure provides cationic properties useful in surfactant applications, antimicrobial formulations, and as a phase transfer catalyst. However, due to its high toxicity classification, its use is restricted to specialized industrial applications with appropriate safety controls.

How to handle trimethyl(oxiran-2-ylmethyl)azanium chloride safely?

Trimethyl(oxiran-2-ylmethyl)azanium chloride requires extensive personal protective equipment due to its severe health hazards. Essential PPE includes chemical-resistant gloves, full face protection or safety goggles, and respiratory protection when handling powders or during potential aerosol generation. Work must be conducted in well-ventilated areas or under fume hoods. Given its carcinogenic, mutagenic, and reproductive toxicity properties, minimize exposure time and ensure proper decontamination procedures. Only trained personnel should handle this substance.

How to store trimethyl(oxiran-2-ylmethyl)azanium chloride correctly?

Trimethyl(oxiran-2-ylmethyl)azanium chloride should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Due to the reactive epoxide group, avoid contact with strong bases, acids, and nucleophiles that could cause ring-opening reactions. Storage areas must be restricted to authorized personnel and equipped with appropriate spill containment measures. Given its multiple health hazards, implement strict inventory control and ensure containers are properly labeled with current safety data sheets readily available.

What to do in case of contact with trimethyl(oxiran-2-ylmethyl)azanium chloride?

Immediate action is critical upon contact with trimethyl(oxiran-2-ylmethyl)azanium chloride due to its severe toxicity. For skin contact, immediately remove contaminated clothing and flush affected areas with copious amounts of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes and seek immediate medical attention due to its eye damage classification. If inhaled, move to fresh air immediately. In all cases, seek immediate medical attention and provide the safety data sheet to medical personnel.

How to dispose of trimethyl(oxiran-2-ylmethyl)azanium chloride appropriately?

Trimethyl(oxiran-2-ylmethyl)azanium chloride must be disposed of as hazardous waste through licensed waste disposal companies due to its carcinogenic, mutagenic, and toxic properties. Never discharge into drains, soil, or water systems. Contaminated materials including packaging, absorbents, and PPE must also be treated as hazardous waste. Disposal must comply with local, national, and EU waste regulations including the Waste Framework Directive. Maintain detailed disposal records and ensure proper waste classification codes are used for tracking.

How to transport trimethyl(oxiran-2-ylmethyl)azanium chloride?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is classified under ADR Class 4.1 (flammable solids) with Packing Group II, indicating moderate danger level for transport. Packages must comply with UN specification requirements and bear appropriate hazard labels including GHS08, GHS07, and GHS05 pictograms. Transport documents must include proper shipping name, UN number, and emergency response information. Only trained personnel should handle loading and unloading operations, and transport vehicles must carry appropriate emergency equipment and spill response materials.

Is trimethyl(oxiran-2-ylmethyl)azanium chloride subject to specific regulations?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is subject to extensive EU chemical regulations including REACH registration requirements and CLP classification obligations. Its multiple hazard classifications (Carc. 1B, Muta. 2, Repr. 2) trigger strict occupational exposure limits and workplace safety requirements under OSH directives. While not currently listed as an SVHC, its hazard profile may result in authorization requirements or use restrictions. Companies must maintain safety data sheets, implement risk management measures, and ensure worker training complies with chemical safety regulations.

Where to buy trimethyl(oxiran-2-ylmethyl)azanium chloride in Europe?

Trimethyl(oxiran-2-ylmethyl)azanium chloride is available through OYSI, a specialized European distributor of technical chemicals with expertise in hazardous substances. Due to its severe toxicity classification and regulatory requirements, this compound is only supplied to qualified industrial users with appropriate handling capabilities and safety protocols. OYSI ensures full regulatory compliance including proper documentation, safety data sheets, and transport classification. Contact OYSI directly to discuss availability, specifications, and regulatory requirements for your specific application.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.