4-chlorophenol

C6H5ClO

CAS106-48-9
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
106-48-9
EC Number
203-402-6
UN Number
2020
Index Number
604-008-00-0
PubChem CID
4684

Physical-chemical properties

Molecular Formula
C6H5ClO
Molar Mass
128.55 g/mol
IUPAC Name
4-chlorophenol

Chemical Identifiers

InChI
InChI=1S/C6H5ClO/c7-5-1-3-6(8)4-2-5/h1-4,8H
InChI Key
WXNZTHHGJRFXKQ-UHFFFAOYSA-N

Overview

4-Chlorophenol (CAS 106-48-9) is an organochlorine compound with antimicrobial properties and moderate toxicity characteristics. This chlorinated phenolic compound represents an important intermediate in chemical manufacturing and industrial applications. With the molecular formula C6H5ClO and a molecular weight of 128.55 g/mol, 4-chlorophenol exhibits the characteristic properties of both phenolic compounds and organochlorine substances. The molecule consists of a benzene ring substituted with both a hydroxyl group and a chlorine atom in the para position, which significantly influences its chemical reactivity and biological activity. From a safety perspective, 4-chlorophenol is classified under multiple acute toxicity categories (Acute Tox. 4) for oral, dermal, and inhalation exposure routes, requiring careful handling procedures in industrial environments. The compound also presents aquatic chronic toxicity concerns (Aquatic Chronic 2), necessitating appropriate environmental protection measures during use and disposal. Transportation falls under ADR Class 6.1, reflecting its toxic nature, and proper protective equipment must be employed when handling this substance. Industrial applications of 4-chlorophenol include its use as a chemical intermediate in pharmaceutical synthesis, particularly in the production of antimicrobial agents and preservatives. The compound also serves as a precursor in the manufacture of specialized polymers and as a component in certain biocide formulations. Unlike some related compounds such as chloromercury, which has more restricted applications due to mercury content, 4-chlorophenol maintains broader industrial utility while requiring appropriate safety protocols. OYSI provides 4-chlorophenol to European industrial customers with comprehensive technical support and regulatory documentation.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2020
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name4-Chlorphenol, flüssig*
Marine PollutantNo

Frequently Asked Questions

What is 4-chlorophenol?

4-chlorophenol is an organic chemical compound with the molecular formula C6H5ClO and CAS number 106-48-9. It belongs to the chlorinated phenol family, featuring a hydroxyl group and a chlorine atom attached to a benzene ring in para position. With a molecular weight of 128.55 g/mol, this substance is classified as moderately toxic and poses environmental hazards, particularly to aquatic organisms.

What are the physicochemical properties of 4-chlorophenol?

4-chlorophenol appears as white to pale yellow crystalline solid at room temperature with a characteristic phenolic odor. It has a melting point of approximately 43°C and is moderately soluble in water. The compound is more soluble in organic solvents like alcohol and ether. It exhibits typical phenolic properties including weak acidity and can form salts with bases.

What is 4-chlorophenol used for?

4-chlorophenol serves primarily as an intermediate in the synthesis of pharmaceuticals, pesticides, and dyes. It is used in the production of antiseptics, disinfectants, and preservatives. The compound also finds applications in the manufacture of herbicides and as a chemical intermediate for producing other chlorinated organic compounds in various industrial processes.

How to handle 4-chlorophenol safely?

4-chlorophenol requires careful handling using appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. The substance carries GHS07 and GHS09 pictograms with 'Warning' signal word, indicating moderate toxicity risks. Avoid skin and eye contact, and prevent environmental release.

How to store 4-chlorophenol correctly?

4-chlorophenol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep away from incompatible materials such as strong oxidizing agents and bases. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures to prevent degradation or hazardous reactions.

What to do in case of contact with 4-chlorophenol?

In case of skin contact with 4-chlorophenol, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. If ingested, do not induce vomiting and seek immediate medical care.

How to dispose of 4-chlorophenol appropriately?

4-chlorophenol must be disposed of as hazardous waste in accordance with local and national regulations. The substance cannot be disposed of in regular waste streams due to its toxicity and environmental impact classification (Aquatic Chronic 2). Contact licensed waste disposal companies specialized in chemical waste treatment. Incineration at high temperatures in authorized facilities is typically the preferred disposal method.

How to transport 4-chlorophenol?

4-chlorophenol is classified under ADR as Class 6.1 (toxic substances), Packing Group III for transport purposes. It requires appropriate hazardous materials packaging, labeling, and documentation during transportation. Vehicles must display proper placarding, and drivers need hazardous materials training certification. Transport should comply with international dangerous goods regulations and route restrictions may apply.

Is 4-chlorophenol subject to specific regulations?

4-chlorophenol is subject to REACH regulation requiring registration for manufacture or import in the EU above certain tonnages. It falls under CLP classification showing Acute Tox. 4 and Aquatic Chronic 2 hazard classes. The substance is not currently listed as SVHC (Substance of Very High Concern), but users must comply with safety data sheet requirements and exposure limit regulations.

Where to buy 4-chlorophenol in Europe?

4-chlorophenol is available through OYSI, a European distributor specializing in technical chemicals. As an established chemical supplier, OYSI can provide this substance to qualified industrial customers with proper documentation and safety data sheets. Professional buyers should contact OYSI directly to discuss specific requirements, quantities, and delivery options across European markets while ensuring regulatory compliance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.