4-chlorophenol

C6H5ClO

CAS106-48-9
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
106-48-9
EC Number
203-402-6
UN Number
2020
Index Number
604-008-00-0
PubChem CID
4684

Physical-chemical properties

Molecular Formula
C6H5ClO
Molar Mass
128.55 g/mol
IUPAC Name
4-chlorophenol

Chemical Identifiers

InChI
InChI=1S/C6H5ClO/c7-5-1-3-6(8)4-2-5/h1-4,8H
InChI Key
WXNZTHHGJRFXKQ-UHFFFAOYSA-N

Overview

4-chlorophenol (CAS 106-48-9) is an aromatic chlorinated compound with antimicrobial properties and moderate toxicity characteristics. This halogenated phenolic compound serves as an important intermediate in chemical manufacturing and industrial processes. With its molecular formula C6H5ClO and molecular weight of 128.55 g/mol, 4-chlorophenol exhibits both the reactive properties of phenols and the enhanced stability provided by chlorine substitution. The compound appears as white to pale yellow crystals with a characteristic phenolic odor. The safety profile of 4-chlorophenol requires careful handling protocols due to its classification as Acute Tox. 4 across multiple exposure routes and its Aquatic Chronic 2 environmental hazard rating. The GHS07 and GHS09 pictograms indicate both health hazards and environmental concerns, while the ADR Class 6.1 classification designates it as a toxic substance for transport purposes. Proper personal protective equipment and containment measures are essential when working with this material. In industrial applications, 4-chlorophenol finds primary use as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a precursor for herbicide manufacturing and is utilized in the production of antimicrobial agents. The compound also functions as a building block for polymer additives and serves in analytical chemistry applications. Unlike more complex organomercury compounds such as chloromercury, 4-chlorophenol offers a more straightforward synthetic pathway while maintaining effective antimicrobial properties. The environmental persistence and bioaccumulation potential of chlorinated phenols require careful waste management and disposal procedures to minimize ecological impact. OYSI maintains reliable supply chains for 4-chlorophenol, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2020
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name4-Chlorphenol, flüssig*
Marine PollutantNo

Frequently Asked Questions

What is 4-chlorophenol?

4-chlorophenol is an organic chemical compound with the molecular formula C6H5ClO and CAS number 106-48-9. It belongs to the family of chlorinated phenols, featuring a benzene ring with both a hydroxyl group (-OH) and a chlorine atom attached at the para position. With a molecular weight of 128.55 g/mol, this compound is classified as moderately toxic and poses environmental hazards, particularly to aquatic ecosystems.

What are the physicochemical properties of 4-chlorophenol?

4-chlorophenol is typically a white to pale yellow crystalline solid at room temperature with a characteristic phenolic odor. It has moderate solubility in water and is readily soluble in organic solvents such as ethanol and acetone. The compound exhibits typical phenolic properties including weak acidity and the ability to form hydrogen bonds. Its chlorinated structure provides increased stability compared to unsubstituted phenol.

What is 4-chlorophenol used for?

4-chlorophenol serves as an important intermediate in the production of pharmaceuticals, pesticides, and dyes. It is commonly used in the synthesis of herbicides and fungicides, particularly in agricultural applications. The compound also finds use in the manufacturing of polymers, resins, and various organic chemicals. Additionally, it serves as a precursor for the production of other chlorinated aromatic compounds in industrial chemistry.

How to handle 4-chlorophenol safely?

4-chlorophenol requires careful handling due to its Acute Tox. 4 classification across multiple exposure routes. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume extraction systems. Avoid inhalation of dust or vapors, and ensure no eating, drinking, or smoking in work areas. Regular hand washing and proper hygiene practices are mandatory.

How to store 4-chlorophenol correctly?

4-chlorophenol should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly sealed to prevent moisture absorption and contamination. Store away from strong oxidizing agents, strong bases, and incompatible materials. Ensure storage areas are equipped with appropriate spill containment measures and emergency response equipment. Maintain proper inventory rotation and regular container inspection for integrity.

What to do in case of contact with 4-chlorophenol?

Immediate action is required for any contact with 4-chlorophenol. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention promptly. Always consult a physician after any significant exposure.

How to dispose of 4-chlorophenol properly?

4-chlorophenol waste must be disposed of as hazardous waste in accordance with local and European regulations. It cannot be disposed of in regular waste streams or sewage systems due to its toxicity and environmental persistence. Contact licensed hazardous waste disposal companies for proper treatment, which typically involves high-temperature incineration or specialized chemical treatment. Maintain proper documentation and waste tracking records as required by applicable regulations.

How to transport 4-chlorophenol?

4-chlorophenol is classified under ADR as Class 6.1 (toxic substances), Packing Group III, indicating moderate toxicity during transport. It must be packaged in UN-approved containers with appropriate labeling including GHS07 and GHS09 pictograms and 'Warning' signal word. Transport documentation must include proper shipping names, hazard classes, and emergency response information. Only trained personnel should handle transportation, and vehicles must carry appropriate emergency equipment.

Is 4-chlorophenol subject to specific regulations?

4-chlorophenol is subject to various European chemical regulations including REACH registration requirements and CLP classification standards. It is not currently listed as a Substance of Very High Concern (SVHC), but its Aquatic Chronic 2 classification means it requires careful environmental risk assessment. Users must comply with occupational exposure limits, waste disposal regulations, and transport requirements. Regular safety data sheet updates and worker training are mandatory compliance elements.

Where to buy 4-chlorophenol in Europe?

4-chlorophenol is available through OYSI, a European distributor of technical chemicals, serving customers across the continent with reliable supply chains. As a specialized chemical requiring proper handling and documentation, it's essential to source from reputable distributors who ensure product quality, regulatory compliance, and proper safety documentation. Professional distributors provide technical support, safety data sheets, and guidance on handling requirements for industrial applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.