3-aminophenol
C6H7NO
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Identification
- CAS Number
- 591-27-5
- EC Number
- 209-711-2
- UN Number
- 2512
- Index Number
- 612-127-00-4
- PubChem CID
- 11568
Physical-chemical properties
- Molecular Formula
- C6H7NO
- Molar Mass
- 109.13 g/mol
- IUPAC Name
- 3-aminophenol
Chemical Identifiers
- InChI
- InChI=1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
- InChI Key
- CWLKGDAVCFYWJK-UHFFFAOYSA-N
Overview
3-aminophenol (CAS 591-27-5) is an aromatic amine compound with hydroxyl and amino functional groups that exhibits moderate toxicity and environmental impact potential. This organic intermediate belongs to the aminophenol family and serves as a crucial building block in various chemical synthesis processes. With its molecular formula C6H7NO and molecular weight of 109.13 g/mol, 3-aminophenol features both phenolic and aniline characteristics, making it a versatile compound for industrial applications. The compound is classified under EC number 209-711-2 and requires careful handling due to its Acute Tox. 4 classification and aquatic chronic toxicity properties. The dual functional nature of 3-aminophenol, containing both hydroxyl (-OH) and amino (-NH2) groups in meta position, provides unique reactivity patterns that distinguish it from other aminophenol isomers. This positioning allows for selective chemical transformations and makes it particularly valuable in pharmaceutical intermediates and dye manufacturing. The compound falls under ADR Class 6.1 for transportation, indicating its toxic nature, and displays GHS07 and GHS09 pictograms with a "Warning" signal word. Key industrial applications include its use as an intermediate in pharmaceutical synthesis, particularly for analgesic and antipyretic compounds, as well as in the production of hair dyes and textile colorants. The compound also finds application in the manufacture of specialty chemicals where its bifunctional nature enables complex molecular architectures. Unlike more complex compounds such as 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1,2,4-triazole used in agricultural applications, 3-aminophenol serves primarily as a versatile synthetic intermediate. OYSI provides reliable access to high-quality 3-aminophenol for European industrial customers requiring consistent supply and technical support.
Safety & Classification
Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2512 |
| ADR Class | 6.1 |
| Packing Group | III |
| Tunnel Code | E |
| Proper Shipping Name | 3-Aminophenol, fest |
| Marine Pollutant | No |
Frequently Asked Questions
What is 3-aminophenol?
3-aminophenol is an organic chemical compound with the molecular formula C6H7NO and a molecular weight of 109.13 g/mol. It belongs to the aminophenol family, featuring both amino (-NH2) and hydroxyl (-OH) functional groups attached to a benzene ring. This aromatic compound with CAS number 591-27-5 appears as crystalline solid and serves as an important intermediate in various chemical syntheses and industrial applications.
What are the physicochemical properties of 3-aminophenol?
3-aminophenol presents as a crystalline solid at room temperature, typically appearing as light brown to gray crystals or powder. It exhibits good solubility in water and polar organic solvents due to its amino and hydroxyl functional groups. The compound has a characteristic phenolic odor and demonstrates amphoteric properties, meaning it can act as both an acid and a base in chemical reactions.
What is 3-aminophenol used for?
3-aminophenol serves primarily as an intermediate in pharmaceutical synthesis, particularly in the production of analgesics and antipyretics. It is widely used in the manufacture of hair dyes and cosmetic formulations due to its color-forming properties. Additionally, it functions as a building block in organic synthesis for producing various aromatic compounds and serves as a precursor in the synthesis of certain polymers and specialty chemicals.
How to handle 3-aminophenol safely?
3-aminophenol requires careful handling due to its Acute Tox. 4 classification. Personal protective equipment including nitrile gloves, safety goggles, and lab coats should be worn during manipulation. Work in well-ventilated areas or under fume hoods to avoid inhalation exposure. Prevent skin and eye contact, and avoid generating dust. Emergency eyewash stations and safety showers should be readily accessible in work areas.
How to store 3-aminophenol correctly?
3-aminophenol should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Keep containers upright and properly labeled with hazard information. Store separately from strong oxidizing agents and acids to prevent incompatible reactions. Maintain storage temperatures below 25°C and ensure the storage area has appropriate spill containment measures and is accessible only to authorized personnel.
What to do in case of contact with 3-aminophenol?
Immediate action is required upon contact with 3-aminophenol. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eyes are affected, flush immediately with clean water for 15 minutes while holding eyelids open. In case of inhalation, move the person to fresh air immediately. Seek medical attention promptly for all exposure routes, especially if symptoms develop.
How to dispose of 3-aminophenol properly?
3-aminophenol disposal must comply with local and national hazardous waste regulations due to its toxicity and environmental hazard classification. The substance cannot be disposed of in regular waste streams or sewers. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small laboratory quantities may be collected through institutional hazardous waste programs. Always consult safety data sheets and local authorities for specific disposal requirements.
How to transport 3-aminophenol?
3-aminophenol is classified as dangerous goods under ADR regulations with Class 6.1 (toxic substances) and Packing Group III. Transportation requires appropriate UN-specification packaging with proper hazard labels and documentation. Vehicles must carry emergency response information and drivers need hazardous materials training certification. Ensure packages are secure, properly labeled, and accompanied by transport documents specifying the toxic nature of the cargo.
Is 3-aminophenol subject to specific regulations?
3-aminophenol is subject to various European regulations including REACH registration requirements and CLP classification standards. It carries GHS07 and GHS09 pictograms with "Warning" signal word due to its acute toxicity and aquatic chronic hazards. While not listed as a SVHC (Substance of Very High Concern), it requires proper hazard communication and safety measures in workplace settings according to occupational health regulations.
Where to buy 3-aminophenol in Europe?
3-aminophenol is available through OYSI, a European distributor specializing in technical chemicals. As an established chemical supplier, OYSI provides 3-aminophenol with proper documentation including safety data sheets and certificates of analysis. The company ensures compliance with European regulations and maintains quality standards for industrial and research applications. Contact OYSI directly for availability, specifications, and technical support for your 3-aminophenol requirements.
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3-aminophenol is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.