3-aminophenol

C6H7NO

CAS591-27-5
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
591-27-5
EC Number
209-711-2
UN Number
2512
Index Number
612-127-00-4
PubChem CID
11568

Physical-chemical properties

Molecular Formula
C6H7NO
Molar Mass
109.13 g/mol
IUPAC Name
3-aminophenol

Chemical Identifiers

InChI
InChI=1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
InChI Key
CWLKGDAVCFYWJK-UHFFFAOYSA-N

Overview

3-aminophenol (CAS 591-27-5) is an aromatic amine compound with hydroxyl and amino functional groups positioned meta to each other on a benzene ring. This organic intermediate serves as a crucial building block in various chemical synthesis processes across multiple industries. With the molecular formula C6H7NO and a molecular weight of 109.13 g/mol, 3-aminophenol exhibits the characteristic properties of both phenolic compounds and aromatic amines. The compound appears as a crystalline solid and demonstrates moderate solubility in water due to its polar functional groups. From a safety perspective, 3-aminophenol is classified under Acute Toxicity Category 4 and Aquatic Chronic Category 2, requiring careful handling protocols in industrial applications. The substance carries GHS07 and GHS09 pictograms with a "Warning" signal word, indicating potential health and environmental hazards. Transportation falls under ADR Class 6.1, reflecting its toxic properties that necessitate appropriate packaging and shipping procedures. The compound finds extensive use in pharmaceutical intermediate synthesis, where its dual functionality enables diverse chemical transformations. It serves as a key precursor in the production of various drugs and active pharmaceutical ingredients. Additionally, 3-aminophenol plays an important role in dye and pigment manufacturing, contributing to the synthesis of azo dyes and other colorants. The hair dye industry also utilizes this compound as an intermediate for producing permanent hair coloring formulations. In chemical synthesis applications, 3-aminophenol shares certain structural similarities with other specialized compounds like 3,5-dichloro-2,6-difluoropyridin-4-amine, though their specific applications differ significantly based on their unique substituent patterns. OYSI provides reliable access to high-quality 3-aminophenol for European industrial customers requiring this essential chemical intermediate.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H332

Harmful if inhaled.

H302

Harmful if swallowed.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2512
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name3-Aminophenol, fest
Marine PollutantNo

Frequently Asked Questions

What is 3-aminophenol?

3-aminophenol is an organic chemical compound with the molecular formula C6H7NO and CAS number 591-27-5. It belongs to the aminophenol family, featuring both amino (-NH2) and hydroxyl (-OH) functional groups attached to a benzene ring. With a molecular weight of 109.13 g/mol, this compound is classified as moderately hazardous with acute toxicity warnings and environmental concerns for aquatic life.

What are the physicochemical properties of 3-aminophenol?

3-aminophenol typically appears as white to light brown crystalline powder or crystals at room temperature. The compound is moderately soluble in water and readily dissolves in alcohols and other polar organic solvents. It has a characteristic phenolic odor and tends to darken upon exposure to air and light due to oxidation. The melting point is around 122-123°C, and it exhibits both basic and acidic properties.

What is 3-aminophenol used for?

3-aminophenol serves primarily as an intermediate in pharmaceutical synthesis, particularly for producing analgesic and antipyretic drugs. It is widely used in the manufacture of hair dyes and cosmetic colorants due to its ability to form stable colored complexes. The compound also finds applications in the production of photographic developers, antioxidants, and various organic synthesis processes in the chemical industry.

How to handle 3-aminophenol safely?

3-aminophenol requires careful handling due to its Acute Tox. 4 classification. Always wear appropriate personal protective equipment including nitrile gloves, safety goggles, and lab coats. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent skin and eye contact, and avoid generating dust. Use non-sparking tools and ensure proper grounding to prevent static electricity buildup during transfer operations.

How to store 3-aminophenol correctly?

3-aminophenol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep away from strong oxidizing agents, acids, and bases to prevent incompatible reactions. Store below 25°C in original packaging and protect from moisture to prevent degradation. Ensure storage areas are equipped with appropriate spill containment and fire protection systems.

What to do in case of contact with 3-aminophenol?

Skin contact with 3-aminophenol requires immediate removal of contaminated clothing and thorough washing with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist.

How to dispose of 3-aminophenol properly?

3-aminophenol disposal must comply with local environmental regulations due to its aquatic toxicity classification (Aquatic Chronic 2). Never dispose of in regular waste or pour down drains. Contact licensed hazardous waste disposal companies for proper treatment through approved incineration or chemical treatment facilities. Small laboratory quantities may be collected through institutional waste programs. Always consult local authorities for specific disposal requirements.

How to transport 3-aminophenol?

3-aminophenol is classified under ADR Class 6.1 (Toxic substances), Packing Group III, requiring specific transport protocols. Packages must be properly labeled with GHS07 and GHS09 pictograms and carry the 'Warning' signal word. Use appropriate packaging that meets UN specifications and ensure proper documentation including transport documents. Only trained personnel should handle transportation, following ADR regulations for toxic substances.

Is 3-aminophenol subject to specific regulations?

3-aminophenol is regulated under various European frameworks including REACH registration requirements and CLP classification standards. It carries mandatory hazard classifications for acute toxicity and aquatic environmental impact. The substance is not currently listed as SVHC (Substance of Very High Concern) under REACH. Users must comply with occupational safety limits and environmental discharge restrictions as specified by local authorities.

Where to buy 3-aminophenol in Europe?

3-aminophenol is available through OYSI, a leading European distributor of specialty chemicals serving industrial and research customers across the continent. OYSI provides high-quality 3-aminophenol with proper documentation, safety data sheets, and regulatory compliance support. Their European distribution network ensures reliable supply chains and technical expertise for safe handling and application guidance to meet your specific requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.