3,5-dimethylphenol

C8H10O

CAS108-68-9
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
108-68-9
EC Number
203-606-5
UN Number
2261
Index Number
604-037-00-9
PubChem CID
7948

Physical-chemical properties

Molecular Formula
C8H10O
Molar Mass
122.16 g/mol
IUPAC Name
3,5-dimethylphenol

Chemical Identifiers

InChI
InChI=1S/C8H10O/c1-6-3-7(2)5-8(9)4-6/h3-5,9H,1-2H3
InChI Key
TUAMRELNJMMDMT-UHFFFAOYSA-N

Overview

3,5-dimethylphenol (CAS 108-68-9) is a substituted phenolic compound with two methyl groups positioned at the 3 and 5 carbon atoms of the benzene ring. This aromatic organic compound, also known by its IUPAC name 3,5-dimethylphenol, belongs to the family of dimethylphenol isomers and serves as an important intermediate in various chemical synthesis processes. With a molecular formula of C8H10O and molecular weight of 122.16 g/mol, this crystalline solid exhibits typical phenolic properties while displaying distinct reactivity patterns due to its specific substitution pattern. The compound presents significant safety considerations, classified under GHS pictograms GHS06 and GHS05 with a "Danger" signal word. Its hazard profile includes Acute Toxicity Category 3 and Skin Corrosion Category 1B, requiring careful handling protocols and appropriate personal protective equipment. The ADR classification of 6.1 indicates its toxic nature during transportation, necessitating compliance with specific shipping regulations for dangerous goods. 3,5-dimethylphenol finds primary applications in the pharmaceutical industry as a synthetic intermediate for various drug compounds, in the production of specialty polymers and resins, and as a building block for antioxidant formulations. Its structural similarity to compounds like 4-methylphenol makes it valuable in comparative synthetic pathways, though its unique substitution pattern provides distinct selectivity advantages in certain chemical transformations. The compound's phenolic hydroxyl group combined with the electron-donating methyl substituents influences its reactivity profile, making it particularly useful in electrophilic aromatic substitution reactions and condensation polymerizations. OYSI maintains reliable supply chains for 3,5-dimethylphenol to support diverse industrial applications across European markets.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2261
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name3,5-Xylenol, fest
Marine PollutantNo

Frequently Asked Questions

What is 3,5-dimethylphenol?

3,5-dimethylphenol is an organic chemical compound with the molecular formula C8H10O and CAS number 108-68-9. It belongs to the phenol family and features two methyl groups positioned at the 3 and 5 positions on the benzene ring. With a molecular weight of 122.16 g/mol, this aromatic compound is classified as a hazardous substance due to its acute toxicity and corrosive properties.

What are the physicochemical properties of 3,5-dimethylphenol?

3,5-dimethylphenol is typically a crystalline solid at room temperature with a characteristic phenolic odor. As a phenolic compound, it exhibits moderate solubility in water and good solubility in organic solvents such as alcohols and ethers. The presence of the hydroxyl group and methyl substituents influences its physical properties, including melting point, boiling point, and volatility characteristics.

What is 3,5-dimethylphenol used for?

3,5-dimethylphenol serves as an important intermediate in organic synthesis and chemical manufacturing. It is primarily used in the production of pharmaceuticals, agrochemicals, and specialty chemicals. The compound also finds applications in the manufacture of antioxidants, polymer additives, and as a building block for more complex aromatic compounds in various industrial processes.

How to handle 3,5-dimethylphenol safely?

3,5-dimethylphenol requires careful handling due to its Acute Tox. 3 and Skin Corr. 1B classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume hoods. Avoid inhalation, ingestion, and direct skin contact. Emergency eyewash and shower facilities should be readily accessible.

How to store 3,5-dimethylphenol correctly?

3,5-dimethylphenol should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep containers away from oxidizing agents and strong bases. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures to prevent degradation. Ensure proper labeling and inventory management according to safety regulations.

What to do in case of contact with 3,5-dimethylphenol?

Immediate action is required upon contact with 3,5-dimethylphenol due to its corrosive nature. For skin contact, remove contaminated clothing and flush affected areas with plenty of water for at least 15 minutes. In case of eye contact, rinse immediately with water for 15 minutes and seek medical attention. If inhaled, move to fresh air. For ingestion, do not induce vomiting and seek immediate medical care.

How to dispose of 3,5-dimethylphenol appropriately?

3,5-dimethylphenol must be disposed of as hazardous waste in accordance with local, national, and EU regulations. The substance cannot be disposed of through regular waste streams due to its toxic and corrosive properties. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Ensure proper documentation and waste tracking throughout the disposal process to maintain regulatory compliance.

How to transport 3,5-dimethylphenol?

3,5-dimethylphenol is classified under ADR as Class 6.1 (toxic substances), Packing Group II, indicating moderate danger during transport. Proper UN-approved packaging must be used, and vehicles must display appropriate hazard placards. Transport documentation must include safety data sheets and emergency response information. Only authorized carriers with proper training and equipment should handle the transportation of this hazardous material.

Is 3,5-dimethylphenol subject to specific regulations?

3,5-dimethylphenol is subject to various European chemical regulations including REACH registration requirements and CLP classification and labeling obligations. The substance is not currently listed as an SVHC (Substance of Very High Concern). Manufacturers and importers must comply with safety data sheet requirements, risk assessment procedures, and workplace exposure limits as defined by relevant occupational health and safety regulations.

Where to buy 3,5-dimethylphenol in Europe?

3,5-dimethylphenol is available through OYSI, a trusted European distributor of specialty chemicals and industrial raw materials. OYSI provides high-quality 3,5-dimethylphenol with proper documentation, safety data sheets, and regulatory compliance support. As an established chemical supplier, OYSI ensures reliable supply chain management and technical support for customers across Europe requiring this specialized phenolic compound.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.