3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is an alkaloid compound commonly known as nicotine, with the molecular formula C10H14N2 and CAS number 54-11-5. This organic compound features a pyridine ring connected to a methylated pyrrolidine ring in a specific stereochemical configuration. With a molecular weight of 162.23 g/mol, it is classified as highly toxic with significant environmental concerns, requiring careful handling in industrial and research applications.

3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is typically a colorless to pale yellow liquid at room temperature with a characteristic sharp, acrid odor. The compound is miscible with water and most organic solvents due to its dual polar and nonpolar character. It has a boiling point around 247°C and is hygroscopic, readily absorbing moisture from air. The substance is volatile and can form vapors at room temperature, contributing to its inhalation hazard potential.

3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is primarily used in pharmaceutical research, analytical chemistry, and as a chemical intermediate in organic synthesis. It serves as a reference standard in laboratories for analytical methods development and quality control procedures. The compound is also utilized in neuroscience research for studying receptor binding and pharmacological effects. Due to its high toxicity classification, its use is restricted to specialized industrial and research applications with appropriate safety measures.

Safe handling of 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine requires full personal protective equipment including nitrile gloves, safety goggles, and respiratory protection due to its Acute Tox. 2 classification. Work must be conducted in a well-ventilated area or fume hood to prevent inhalation exposure. Avoid skin contact and ingestion at all costs, as the substance is highly toxic through all exposure routes. Emergency shower and eyewash stations should be readily accessible when working with this dangerous material.

3-[(2S)-1-methylpyrrolidin-2-yl]pyridine must be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight in tightly sealed containers. Storage should be in a designated hazardous materials area with restricted access due to its high toxicity. The substance should be kept away from oxidizing agents and strong acids. Containers must be properly labeled with GHS06 and GHS09 pictograms, and storage areas should have appropriate spill containment measures to prevent environmental release.

Immediate action is critical due to the substance's Acute Tox. 2 classification for all exposure routes. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with plenty of water for 15 minutes and remove contact lenses if present. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting. Seek immediate medical attention for any exposure and provide safety data sheet to medical personnel.

Disposal of 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine must be conducted through licensed hazardous waste disposal companies due to its high toxicity and environmental hazard classification. The substance cannot be disposed of in regular waste streams or sewage systems due to its Aquatic Chronic 2 classification. Waste must be collected in appropriate containers, properly labeled, and handled according to local and EU waste regulations. Incineration at authorized high-temperature facilities is typically the preferred disposal method for this type of toxic organic compound.

Transportation of 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine falls under ADR Class 6.1 (Toxic substances), Packing Group II, indicating high toxicity requiring special transport precautions. Packages must bear appropriate hazard labels and comply with UN packaging specifications for toxic liquids. Transport vehicles must carry appropriate emergency equipment and documentation. Drivers require ADR training for dangerous goods transport, and shipments must follow designated routing restrictions. Emergency response information must accompany all shipments for potential incident management.

3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is subject to extensive EU regulations including REACH registration requirements and CLP classification as a highly toxic substance with environmental hazards. While not currently listed as an SVHC, its Acute Tox. 2 classification requires compliance with strict labeling, safety data sheet, and handling requirements. The substance may be subject to additional restrictions under national legislation due to its toxicity profile. Import/export may require specific permits and documentation depending on intended use and quantities.

3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is available through OYSI, a specialized European distributor of technical chemicals with expertise in handling highly toxic substances. OYSI ensures full regulatory compliance, proper packaging, and safe transport of this ADR Class 6.1 material throughout Europe. Due to the substance's high toxicity classification and regulatory requirements, purchases are restricted to qualified industrial and research customers with appropriate handling capabilities and valid business justification for use.