3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
C10H14N2
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Identification
- CAS Number
- 54-11-5
- EC Number
- 200-193-3
- UN Number
- 1654
- Index Number
- 614-001-00-4
- PubChem CID
- 89594
Physical-chemical properties
- Molecular Formula
- C10H14N2
- Molar Mass
- 162.23 g/mol
- IUPAC Name
- 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
Chemical Identifiers
- InChI
- InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
- InChI Key
- SNICXCGAKADSCV-JTQLQIEISA-N
Overview
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine (CAS 54-11-5) is a heterocyclic alkaloid compound with potent biological activity and significant toxicity concerns. This chiral nitrogen-containing compound, with molecular formula C10H14N2 and molecular weight 162.23 g/mol, represents a bicyclic structure combining a pyridine ring with a methylated pyrrolidine moiety. The (2S) stereochemistry indicates the specific spatial arrangement that contributes to its distinctive pharmacological properties. Also known by its EC number 200-193-3, this substance belongs to the family of pyridine alkaloids and shares structural similarities with other nitrogen-containing aromatic compounds. The compound exhibits extremely high toxicity across multiple exposure routes, classified as Acute Tox. 2 for oral, dermal, and inhalation pathways under the CLP regulation. This classification necessitates the "Danger" signal word and requires both GHS06 (skull and crossbones) and GHS09 (environmental hazard) pictograms on safety labeling. Its ADR classification of 6.1 indicates it falls under toxic substances for transport purposes. Additionally, the Aquatic Chronic 2 classification highlights its potential for long-term environmental harm to aquatic ecosystems. In industrial applications, this compound finds primary use in pharmaceutical research as a reference standard and in specialized chemical synthesis processes. It also serves as an intermediate in the production of certain agrochemical formulations and as a research tool in neuroscience studies. Unlike related compounds such as N-methylaniline, which has broader industrial applications, this substance requires extremely careful handling protocols due to its high toxicity profile. OYSI maintains availability of this specialized compound for qualified industrial and research customers, ensuring full regulatory compliance and comprehensive safety documentation.
Safety & Classification
Acute Tox. 2; Acute Tox. 2; Acute Tox. 2; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1654 |
| ADR Class | 6.1 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | Nicotin |
| Marine Pollutant | No |
Frequently Asked Questions
What is 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is a pyrrolidine alkaloid compound with the molecular formula C10H14N2 and CAS number 54-11-5. This organic compound features a pyridine ring connected to a methylated pyrrolidine structure in a specific stereochemical configuration. With a molecular weight of 162.23 g/mol, it is classified as highly toxic with acute toxicity category 2 and presents environmental hazards to aquatic life with chronic effects.
What are the physicochemical properties of 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is an organic compound with molecular formula C10H14N2 and molecular weight 162.23 g/mol. As a nitrogen-containing heterocyclic compound, it typically exists as a liquid at room temperature with characteristic alkaloid properties. The compound contains both pyridine and pyrrolidine functional groups, which influence its solubility behavior and chemical reactivity. Specific physical properties such as boiling point, density, and solubility parameters should be confirmed from detailed technical datasheets.
What is 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine used for?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine serves as an important intermediate in pharmaceutical and chemical synthesis applications. This compound is primarily utilized in research and development activities, particularly in the synthesis of complex organic molecules and pharmaceutical compounds. Its unique pyrrolidine-pyridine structure makes it valuable for medicinal chemistry applications and as a building block in fine chemical manufacturing. Due to its high toxicity classification, its use is restricted to professional and industrial applications with appropriate safety measures.
How to handle 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine safely?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine requires extreme caution due to its Acute Toxicity Category 2 classification across multiple exposure routes. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas or fume hoods. Avoid skin contact, inhalation, and ingestion completely. Work should be conducted by trained personnel only, following strict safety protocols. Emergency procedures and first aid measures must be readily available. The compound displays GHS06 (skull and crossbones) and GHS09 (environmental) hazard pictograms.
How to store 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine correctly?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine must be stored in a secure, well-ventilated area away from heat sources, ignition sources, and incompatible materials. Storage should be in original, tightly sealed containers made of compatible materials, preferably in a designated chemical storage facility with appropriate containment measures. Due to its high toxicity and environmental hazard classification, access must be restricted to authorized personnel only. Storage areas should be equipped with appropriate spill containment and emergency response equipment.
What to do in case of contact with 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine?
Immediate action is critical due to the compound's Acute Toxicity Category 2 classification. For skin contact, immediately remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. In case of eye contact, flush with clean water for 15 minutes. If ingested, do not induce vomiting and seek immediate medical attention. Always contact poison control or emergency services promptly and provide the safety data sheet to medical personnel.
How to dispose of 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine appropriately?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine must be disposed of as hazardous waste through licensed waste management facilities due to its high toxicity and environmental hazard classification. The compound cannot be disposed of in regular waste streams or sewage systems due to its Aquatic Chronic 2 classification. Waste disposal must comply with local, national, and EU regulations including the Waste Framework Directive. Empty containers should also be treated as hazardous waste. Consult local environmental authorities for specific disposal requirements and approved waste contractors.
How to transport 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is classified under ADR Class 6.1 (Toxic substances), Packing Group II, indicating high toxicity requiring strict transport regulations. Transportation must comply with ADR/RID regulations for dangerous goods, requiring appropriate packaging, labeling, and documentation. Vehicles must display proper hazard placards and drivers need dangerous goods training certification. Transport should only be conducted by licensed dangerous goods carriers with appropriate emergency response procedures. Proper shipping papers and emergency response information must accompany all shipments.
Is 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine subject to specific regulations?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification and labeling obligations. The compound is not currently identified as a Substance of Very High Concern (SVHC) but must comply with standard chemical safety requirements. Its Acute Toxicity Category 2 classification requires specific handling, storage, and transport procedures under multiple regulatory frameworks. Users must maintain safety data sheets, conduct risk assessments, and implement appropriate risk management measures according to REACH and occupational safety regulations.
Where to buy 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine in Europe?
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. As a professional chemical supplier, OYSI can provide this highly regulated compound to qualified industrial and research customers with appropriate handling capabilities and regulatory compliance. Due to the compound's high toxicity classification and regulatory requirements, purchases are restricted to professional users with demonstrated expertise in handling dangerous chemicals. Contact OYSI directly for availability, specifications, and regulatory documentation requirements.
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3-[(2S)-1-methylpyrrolidin-2-yl]pyridine is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.