Pyrrolidine

Pyrrolidine is a saturated five-membered heterocyclic amine with the molecular formula C4H9N and CAS number 123-75-1. This organic compound has a molecular weight of 71.12 g/mol and consists of a five-membered ring containing four carbon atoms and one nitrogen atom. It serves as an important building block in organic synthesis and pharmaceutical chemistry due to its basic nitrogen functionality and ring structure.

Pyrrolidine is a colorless liquid at room temperature with a characteristic ammonia-like or fishy odor. It has a boiling point of approximately 87°C and is highly soluble in water due to its basic nitrogen atom which can form hydrogen bonds. The compound is also miscible with most organic solvents including alcohols and ethers. It exhibits basic properties with a pKa around 11.3, making it a relatively strong organic base.

Pyrrolidine is primarily used as a building block in pharmaceutical synthesis, particularly in the production of various drugs and active pharmaceutical ingredients. It serves as an intermediate in organic synthesis for creating complex molecules and is utilized in the manufacture of agrochemicals, polymers, and specialty chemicals. The compound is also employed as a catalyst in certain organic reactions and as a solvent in specific industrial applications.

Pyrrolidine should be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation of vapors. Avoid contact with skin, eyes, and clothing. Keep away from heat sources, sparks, and open flames as it is a flammable liquid. Use non-sparking tools and ensure proper grounding when transferring the material.

Pyrrolidine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers away from incompatible materials such as strong acids and oxidizing agents. Storage areas should be equipped with appropriate fire suppression systems due to its flammable nature. Containers should be properly labeled and stored according to local fire codes and chemical storage regulations.

In case of skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with plenty of clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical attention if breathing difficulties occur. In case of ingestion, do not induce vomiting and seek immediate medical attention.

Pyrrolidine should be disposed of according to local, regional, and national waste regulations. It must not be poured down drains or released into the environment. Contact authorized waste disposal companies for proper treatment and disposal. Small quantities may be neutralized with appropriate acids under controlled conditions by trained personnel, but this should only be done following proper safety protocols and regulatory guidelines.

Pyrrolidine is classified under ADR as Class 3 (flammable liquids), Packing Group II, indicating it is a moderately dangerous flammable liquid for transport. It must be packaged in UN-approved containers with proper labeling and documentation. Vehicles transporting this material must comply with ADR regulations including appropriate placarding, driver training, and equipment requirements. Proper shipping papers and emergency response information must accompany shipments.

Pyrrolidine is subject to standard chemical regulations including REACH registration requirements in Europe and CLP classification and labeling regulations. It is not classified as a Substance of Very High Concern (SVHC) under REACH. Users must comply with workplace safety regulations, environmental protection laws, and proper chemical handling standards. Industrial users may need to register uses and maintain safety data sheets according to applicable chemical safety regulations.

Pyrrolidine is available through OYSI, a specialized European distributor of technical chemicals serving industrial and professional customers across Europe. OYSI provides high-quality pyrrolidine with proper documentation, safety data sheets, and regulatory compliance support. As an established chemical distributor, OYSI ensures reliable supply chains and technical support for customers requiring this important organic intermediate for their industrial applications and synthesis processes.