3-chloro-4-nitroaniline

C6H5ClN2O2

CAS825-41-2
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
825-41-2
UN Number
2237
Index Number
610-006-00-0
PubChem CID
69996

Physical-chemical properties

Molecular Formula
C6H5ClN2O2
Molar Mass
172.57 g/mol
IUPAC Name
3-chloro-4-nitroaniline

Chemical Identifiers

InChI
InChI=1S/C6H5ClN2O2/c7-5-3-4(8)1-2-6(5)9(10)11/h1-3H,8H2
InChI Key
LDSIOPGMLLPSSR-UHFFFAOYSA-N

Overview

3-chloro-4-nitroaniline (CAS 825-41-2) is a chlorinated nitroaniline derivative with significant toxicological properties and industrial chemical applications. This aromatic amine compound represents an important intermediate in organic synthesis, characterized by the presence of both chlorine and nitro functional groups on the benzene ring. With a molecular formula of C6H5ClN2O2 and molecular weight of 172.57 g/mol, 3-chloro-4-nitroaniline exhibits the typical reactivity patterns associated with substituted anilines while presenting unique chemical behavior due to its specific substitution pattern. The compound is classified under multiple hazard categories, including acute toxicity categories 1 and 2, specific target organ toxicity (repeated exposure) category 2, and aquatic chronic toxicity category 2. These classifications necessitate careful handling protocols and appropriate safety measures during storage, transportation, and processing. The GHS pictograms GHS06, GHS08, and GHS09 indicate skull and crossbones, health hazard, and environmental hazard symbols respectively, emphasizing the compound's dangerous nature and potential environmental impact. In industrial applications, 3-chloro-4-nitroaniline serves primarily as a chemical intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. It is particularly valuable in the production of azo dyes and as a building block for more complex aromatic compounds. The compound shares structural similarities with other nitroaniline derivatives such as 2,4-dinitroaniline, though its unique substitution pattern provides distinct synthetic advantages in specific applications. As a class 6.1 ADR substance, this material requires specialized transportation and handling expertise. OYSI provides 3-chloro-4-nitroaniline to qualified industrial customers across Europe, ensuring compliance with all relevant safety and regulatory requirements.

Safety & Classification

Danger
Classification:

Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; STOT RE 2 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H330

Fatal if inhaled.

H310

Fatal in contact with skin.

H300

Fatal if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Fatal

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Fatal

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Fatal

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2237
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name3-Chlor-4-nitroanilin, fest
Marine PollutantNo

Frequently Asked Questions

What is 3-chloro-4-nitroaniline?

3-chloro-4-nitroaniline is an aromatic amine compound with the molecular formula C6H5ClN2O2 and CAS number 825-41-2. This chemical substance contains both chlorine and nitro functional groups attached to an aniline ring structure, giving it a molecular weight of 172.57 g/mol. It is classified as a highly hazardous chemical with acute toxicity properties and requires careful handling due to its dangerous classification under GHS regulations.

What are the physicochemical properties of 3-chloro-4-nitroaniline?

3-chloro-4-nitroaniline is typically a solid crystalline compound at room temperature with a characteristic yellow to orange coloration. As an aromatic amine derivative, it exhibits limited water solubility but dissolves in organic solvents. The presence of both electron-withdrawing groups (chlorine and nitro) on the benzene ring influences its chemical reactivity and stability. Its molecular structure makes it relatively stable under normal conditions but reactive under specific chemical environments.

What is 3-chloro-4-nitroaniline used for?

3-chloro-4-nitroaniline serves primarily as an intermediate in the synthesis of dyes, pigments, and pharmaceuticals. It is commonly used in the production of azo dyes and other colorants for textile and industrial applications. The compound also functions as a building block in organic synthesis for creating more complex chemical structures. Its unique substitution pattern makes it valuable in specialized chemical manufacturing processes requiring specific reactivity profiles.

How to handle 3-chloro-4-nitroaniline safely?

3-chloro-4-nitroaniline requires strict safety protocols due to its Acute Tox. 1 and 2 classifications. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection when handling this substance. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. The compound's high toxicity demands immediate medical attention if exposure occurs, and all handling procedures must follow established safety protocols.

How to store 3-chloro-4-nitroaniline correctly?

3-chloro-4-nitroaniline must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Storage areas should be equipped with appropriate containment measures and emergency response equipment. The compound should be kept away from strong oxidizers and reducing agents that could cause dangerous reactions. Regular inspection of storage containers is essential to detect any signs of degradation or leakage.

What to do in case of contact with 3-chloro-4-nitroaniline?

Immediate action is critical due to the high acute toxicity of 3-chloro-4-nitroaniline. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes. If inhaled, move the person to fresh air immediately. Seek immediate medical attention for any exposure route, as this compound can cause severe health effects requiring professional medical intervention.

How to dispose of 3-chloro-4-nitroaniline appropriately?

3-chloro-4-nitroaniline disposal must comply with local, national, and EU waste regulations due to its hazardous classification. The compound cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment. Contact licensed hazardous waste disposal companies for proper collection and treatment. Incineration at high temperatures in approved facilities is typically the preferred disposal method. All disposal activities must be documented according to waste tracking regulations.

How to transport 3-chloro-4-nitroaniline?

3-chloro-4-nitroaniline is classified as ADR Class 6.1, Packing Group III for transport purposes. This classification identifies it as a toxic substance requiring specific packaging, labeling, and documentation during transportation. Packages must display appropriate hazard labels and proper shipping names. Drivers must possess valid ADR certification for Class 6.1 substances. Transport vehicles require appropriate emergency equipment and documentation, including safety data sheets and emergency response procedures.

Is 3-chloro-4-nitroaniline subject to particular regulations?

3-chloro-4-nitroaniline is subject to comprehensive EU chemical regulations including REACH registration requirements and CLP classification obligations. While not currently listed as an SVHC substance, its high toxicity classification means it falls under strict handling and notification requirements. Industrial users must comply with occupational exposure limits and workplace safety regulations. Import and use may require specific authorizations depending on quantities and applications, particularly in pharmaceutical and dye manufacturing sectors.

Where to buy 3-chloro-4-nitroaniline in Europe?

OYSI serves as a reliable European distributor for 3-chloro-4-nitroaniline, providing quality chemical products to industrial customers across Europe. As a specialized chemical distributor, OYSI ensures proper handling, documentation, and regulatory compliance for this hazardous substance. Customers can access technical support and safety documentation along with their chemical supply needs. Contact OYSI directly to discuss specific requirements, quantities, and delivery arrangements for 3-chloro-4-nitroaniline procurement.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.