3-chloro-4-nitroaniline

3-chloro-4-nitroaniline is an aromatic amine compound with the molecular formula C6H5ClN2O2 and CAS number 825-41-2. This chemical substance features both chlorine and nitro functional groups attached to an aniline backbone, giving it a molecular weight of 172.57 g/mol. It is classified as a highly toxic substance with significant health and environmental hazards, requiring careful handling and storage procedures in industrial applications.

3-chloro-4-nitroaniline is typically a crystalline solid at room temperature with a characteristic yellow to orange color. As an aromatic amine derivative, it exhibits limited water solubility but dissolves well in organic solvents such as alcohols and ethers. The compound has a molecular weight of 172.57 g/mol and contains both electron-withdrawing groups (chloro and nitro) that influence its chemical reactivity and stability properties.

3-chloro-4-nitroaniline is primarily used as an intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. In the chemical industry, it serves as a building block for producing azo dyes and other colorants used in textiles and printing applications. Additionally, it functions as a precursor in the manufacture of certain pharmaceutical active ingredients and specialty chemicals requiring specific substitution patterns on the aromatic ring.

3-chloro-4-nitroaniline requires strict safety measures due to its high toxicity classification (Acute Tox. 1 and 2). Personnel must wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. All handling procedures must follow established safety protocols to minimize skin contact and vapor exposure risks.

3-chloro-4-nitroaniline must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. The substance should be kept in tightly sealed, labeled containers to prevent moisture absorption and contamination. Storage areas must be secured and accessible only to trained personnel due to the compound's high toxicity. Regular inspection of storage conditions and container integrity is essential for maintaining safety standards.

Immediate action is required for any contact with 3-chloro-4-nitroaniline due to its high toxicity. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes. If inhaled, move to fresh air immediately. Seek immediate medical attention in all cases of exposure and provide safety data sheet information to medical personnel.

3-chloro-4-nitroaniline disposal must comply with local and international hazardous waste regulations due to its toxic and environmentally harmful properties. The substance requires treatment by licensed hazardous waste disposal facilities equipped to handle toxic organic compounds. Incineration at high temperatures in specialized facilities is typically the preferred disposal method. Never dispose of this chemical through regular waste streams or drainage systems due to environmental contamination risks.

3-chloro-4-nitroaniline is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transportation purposes. Shipments must use UN-approved packaging and proper hazard labels including the toxic substance pictogram. Transport documentation must include proper shipping names, hazard classifications, and emergency response information. Only certified carriers experienced in handling toxic chemicals should transport this substance, following all applicable dangerous goods regulations.

3-chloro-4-nitroaniline is subject to comprehensive chemical safety regulations including REACH registration requirements in Europe and CLP classification obligations. The substance carries multiple hazard classifications (Acute Tox. 1-2, STOT RE 2, Aquatic Chronic 2) requiring detailed safety data sheets and risk assessments. While not currently listed as an SVHC substance, its high toxicity classification means it may face additional restrictions or monitoring requirements under evolving chemical safety legislation.

3-chloro-4-nitroaniline is available through OYSI, a specialized European distributor of technical chemicals and intermediates. As a professional chemical supplier, OYSI provides proper documentation, safety data sheets, and regulatory compliance support for this highly toxic substance. Due to the strict handling and regulatory requirements associated with this chemical, procurement should only be conducted through established distributors with expertise in hazardous chemical supply chains and appropriate safety protocols.