3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is a synthetic organic compound with the molecular formula C16H8Cl2FN5O and CAS number 136426-54-5. This quinazoline derivative contains multiple halogen atoms (chlorine and fluorine) and a triazole ring system. With a molecular weight of 376.2 g/mol, it represents a complex heterocyclic structure typically used in pharmaceutical or agrochemical applications due to its specific bioactive properties.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is a crystalline solid at room temperature with a molecular weight of 376.2 g/mol. The compound contains multiple aromatic rings with halogen substituents, which typically confer low water solubility and moderate lipophilicity. The presence of nitrogen-containing heterocycles and halogen atoms influences its chemical stability and reactivity. Specific physical properties such as melting point and solubility data should be obtained from detailed analytical certificates.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is primarily used as an intermediate in pharmaceutical synthesis and agrochemical research. The quinazoline scaffold combined with triazole functionality makes it valuable for developing bioactive compounds with potential antifungal, antiviral, or anticancer properties. It serves as a building block in medicinal chemistry for creating more complex therapeutic molecules. Industrial applications include use in specialized chemical synthesis and research laboratories developing new active pharmaceutical ingredients.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one requires careful handling due to its Acute Tox. 3 and 4 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin contact and ingestion. The compound's skin irritant properties (Skin Irrit. 2) necessitate immediate washing if contact occurs. Handle with appropriate laboratory safety protocols for toxic substances.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one should be stored in a cool, dry place away from direct sunlight and heat sources. Keep containers tightly closed in a well-ventilated area, preferably in a dedicated chemical storage facility. Due to its toxic properties, store separately from food, feed, and incompatible materials. Maintain storage temperature as specified on the product label. Ensure proper labeling with hazard information and implement appropriate access controls to prevent unauthorized handling.

Immediate action is required upon contact with 3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one due to its toxic and irritant properties. For skin contact, immediately wash with plenty of soap and water for at least 15 minutes. If inhaled, move to fresh air immediately. In case of eye contact, rinse thoroughly with water for several minutes. If ingested, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for complete first aid procedures and contact poison control if necessary.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one must be disposed of as hazardous waste due to its toxic properties and environmental hazard classification (Aquatic Acute 1). Contact licensed hazardous waste disposal companies for proper handling and destruction. Never dispose of this substance in regular waste streams, sewers, or water bodies. Follow local and national regulations for hazardous chemical disposal. Maintain disposal records as required by environmental authorities. Consider incineration at authorized high-temperature facilities as the preferred disposal method.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transportation. This classification requires appropriate UN-specification packaging, proper labeling with toxic substance markings, and accompanying transport documents. Vehicles must display appropriate placards during transport. Drivers need ADR training certification for Class 6.1 materials. Ensure compliance with international dangerous goods regulations (ADR/RID/IMDG/IATA) depending on transport mode. Use certified packaging providers and experienced logistics companies familiar with toxic substance transport requirements.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is subject to standard EU chemical regulations including REACH and CLP classifications. The substance is not currently listed as a Substance of Very High Concern (SVHC). However, its toxic properties require compliance with workplace safety regulations, environmental protection laws, and proper classification under the CLP Regulation with appropriate hazard pictogrammes (GHS06, GHS08, GHS09). Users must ensure proper risk assessments, safety data sheet distribution, and worker protection measures according to relevant occupational health and safety directives.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chain management, proper documentation, and regulatory compliance support for hazardous substances throughout Europe. As an established chemical distributor, OYSI ensures appropriate packaging, transport compliance, and technical support for professional users. Contact OYSI directly for availability, specifications, and regulatory documentation including safety data sheets and certificates of analysis for this specialized quinazoline compound.