3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is a synthetic organic compound with CAS number 136426-54-5 and molecular formula C16H8Cl2FN5O. This quinazolinone derivative contains multiple functional groups including dichlorophenyl, fluoro, and triazole moieties. With a molecular weight of 376.2 g/mol, it belongs to the class of heterocyclic compounds and is classified as a hazardous substance requiring careful handling due to its toxicological properties.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is a solid crystalline compound at room temperature with a molecular weight of 376.2 g/mol. The presence of multiple aromatic rings and halogen substituents suggests limited water solubility but good solubility in organic solvents. The compound's stability and specific physical properties like melting point, color, and odor depend on purity and crystalline form, requiring analytical characterization for precise determination.

3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one is primarily used as a research chemical and pharmaceutical intermediate in drug discovery and development. Its quinazolinone structure with triazole and halogenated aromatic substituents makes it valuable for medicinal chemistry applications, particularly in the development of antifungal or anticancer agents. The compound may also serve as a synthetic building block for creating more complex pharmaceutical compounds.

Safe handling requires wearing appropriate personal protective equipment including nitrile gloves, safety goggles, and lab coats due to its Acute Tox. 3 and Skin Irrit. 2 classifications. Work should be conducted in a well-ventilated area or fume hood to prevent inhalation exposure. Avoid skin and eye contact, and prevent dust formation during weighing and transfer operations. Always wash hands thoroughly after handling and follow good laboratory practices.

Proper storage requires keeping the compound in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Store in tightly sealed original containers, preferably under inert atmosphere to prevent degradation. Due to its hazardous classification, it should be stored in a designated chemical storage area with restricted access, separated from incompatible materials like strong oxidizers and reducing agents. Maintain storage temperature as recommended by the manufacturer.

Immediate first aid measures include removing contaminated clothing and flushing affected skin areas with plenty of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water and remove contact lenses if easily removable. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician in case of exposure, bringing the safety data sheet for reference.

Disposal must comply with local, national, and international regulations for hazardous waste due to its toxic and environmentally hazardous properties. The compound should be collected in suitable containers and disposed of through licensed hazardous waste disposal companies. Never dispose of in regular trash, sewers, or water bodies due to its Aquatic Acute 1 classification. Incineration at authorized facilities capable of handling halogenated compounds is typically the preferred disposal method.

Transportation is regulated under ADR Class 6.1 (Toxic substances), Packing Group III, requiring appropriate packaging, labeling, and documentation. Packages must bear proper shipping names, UN numbers, and hazard labels including GHS06, GHS08, and GHS09 pictograms. Only authorized carriers trained in hazardous materials transport should handle shipments. Proper shipping papers and emergency response information must accompany the shipment throughout transit.

The compound is subject to European CLP regulation requiring proper classification and labeling with Danger signal word and appropriate pictograms. Under REACH regulation, it requires registration for commercial use above tonnage thresholds. It is not currently listed as a Substance of Very High Concern (SVHC). Import/export may require permits depending on end-use and destination country regulations. Workplace exposure limits and safety measures must comply with national occupational health regulations.

OYSI serves as a reliable European distributor for 3-(2,4-dichlorophenyl)-6-fluoro-2-(1,2,4-triazol-1-yl)quinazolin-4-one, providing quality chemicals to research institutions and pharmaceutical companies across Europe. As a specialized chemical distributor, OYSI ensures proper handling, packaging, and regulatory compliance for hazardous substances. Contact OYSI directly for availability, specifications, and pricing information, along with technical support and safety documentation required for your specific application needs.