[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate is a synthetic organic compound with CAS number 70987-78-9 and molecular formula C10H12O4S. This substance features an epoxide ring (oxirane) attached to a tosylate group, making it a valuable intermediate in organic synthesis. With a molecular weight of 228.27 g/mol, it belongs to the class of glycidyl tosylates and is classified as highly hazardous due to its carcinogenic and mutagenic properties.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate is typically a solid or viscous liquid at room temperature with a molecular weight of 228.27 g/mol. The compound contains both polar tosylate and reactive epoxide functional groups, which influence its solubility characteristics. Due to the presence of the aromatic ring and polar sulfonate group, it likely exhibits moderate solubility in polar organic solvents while being less soluble in water.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate serves as an important synthetic intermediate in pharmaceutical and chemical manufacturing. The compound's epoxide and tosylate functionalities make it valuable for nucleophilic substitution reactions and ring-opening processes. It is commonly used in the synthesis of complex organic molecules, particularly in the development of pharmaceutical compounds where stereochemical control is crucial, given its (2S)-configuration.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate requires strict safety measures due to its carcinogenic (1B) and mutagenic (2) properties. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. The substance can cause severe eye damage and skin sensitization, requiring immediate safety protocols and emergency procedures to be readily available.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Due to its reactive epoxide group, avoid exposure to acids, bases, and nucleophiles that could cause ring-opening reactions. Storage areas must be designed to contain spills and prevent environmental release, considering its aquatic chronic toxicity classification. Access should be restricted to trained personnel only.

Immediate action is required upon contact with [(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate due to its severe hazard profile. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. In case of eye contact, flush immediately with water for at least 15 minutes and seek medical attention urgently due to its eye-damaging properties. If inhaled, move to fresh air immediately and seek medical attention, especially considering its carcinogenic nature.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate must be disposed of as hazardous waste through licensed waste management companies due to its carcinogenic and mutagenic properties. Disposal must comply with local, national, and EU waste regulations including the Waste Framework Directive. The substance cannot be disposed of in regular waste streams and requires specialized treatment facilities. Container disposal must also follow hazardous waste protocols, and all disposal activities must be properly documented.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. Transport requires appropriate packaging, labeling with GHS pictograms (GHS08, GHS05, GHS07, GHS09), and proper documentation including safety data sheets. Vehicles must comply with ADR regulations for Class 9 substances, and drivers require appropriate training. Emergency response information must accompany shipments, and transport routes should consider environmental protection requirements.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate is subject to extensive EU chemical regulations including REACH registration requirements and CLP classification obligations. While not currently listed as an SVHC, its Carcinogenic 1B classification subjects it to strict occupational exposure controls under EU workplace directives. The substance requires safety data sheets, appropriate hazard communication, and may be subject to authorization or restriction procedures. Users must comply with national implementation of EU chemical safety legislation.

[(2S)-oxiran-2-yl]methyl 4-methylbenzenesulfonate is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides comprehensive regulatory documentation, safety data sheets, and technical support for this controlled substance. Due to its hazardous classification, purchases require appropriate documentation of end-use and compliance with regulatory requirements. Contact OYSI directly for availability, specifications, and regulatory guidance for your specific application.