N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine
C10H9NOS
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Identification
- CAS Number
- 147396-08-5
- EC Number
- 410-780-8
- UN Number
- 3077
- Index Number
- 612-157-00-8
- PubChem CID
- 72729745
Physical-chemical properties
- Molecular Formula
- C10H9NOS
- Molar Mass
- 191.25 g/mol
- IUPAC Name
- N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine
Chemical Identifiers
- InChI
- InChI=1S/C10H9NOS/c1-7(11-12)10-6-8-4-2-3-5-9(8)13-10/h2-6,12H,1H3
- InChI Key
- LYNWDHNMGAKITE-UHFFFAOYSA-N
Overview
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine (CAS 147396-08-5) is a benzothiophene-derived oxime compound with notable chemical reactivity and specialized industrial applications. This organic compound, with molecular formula C10H9NOS and molecular weight 191.25 g/mol, belongs to the hydroxylamine derivatives family and features a distinctive benzothiophene ring system. The compound exhibits characteristic oxime functionality, making it valuable in various synthetic chemistry applications where controlled nitrogen introduction is required. Its structural similarity to other heterocyclic compounds, including benzene-1,4-diol derivatives, positions it within a broader class of aromatic compounds used in pharmaceutical and chemical synthesis. From a safety perspective, N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine requires careful handling due to its classification under multiple hazard categories. The compound presents acute toxicity concerns (Category 4), potential for specific target organ toxicity following repeated exposure (Category 2), serious eye damage risks (Category 1), and skin sensitization potential (Category 1). Additionally, it poses chronic aquatic toxicity risks (Category 2). These properties necessitate appropriate personal protective equipment and containment measures during handling and storage. The compound is classified under ADR Class 9 for transportation purposes. Industrial applications of this specialized chemical intermediate include pharmaceutical synthesis, where its oxime functionality serves as a building block for more complex molecules, agrochemical manufacturing for active ingredient development, and specialty chemical production requiring benzothiophene-containing compounds. The compound's unique structural features make it particularly valuable in medicinal chemistry research and custom synthesis projects. OYSI maintains reliable supply chains for N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.
Safety & Classification
Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 2
GHS Pictograms
Exclamation Mark
GHS07
Harmful. May cause irritation, allergic reactions, or drowsiness.
Health Hazard
GHS08
Serious health hazard. May cause cancer, organ damage, or genetic defects.
Corrosion
GHS05
Corrosive. Causes severe skin burns and eye damage.
Environment
GHS09
Environmental hazard. Toxic to aquatic life with long lasting effects.
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | cis-1-Benzo[b]thien-2-ylethanonoxim-hydrochlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is an organic chemical compound with the molecular formula C10H9NOS and CAS number 147396-08-5. This substance belongs to the hydroxylamine derivatives family and contains a benzothiophene moiety. With a molecular weight of 191.25 g/mol, it is classified as a hazardous substance requiring careful handling due to its toxicological properties and potential environmental impact.
What are the physicochemical properties of N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is a solid organic compound at room temperature with a molecular weight of 191.25 g/mol. The substance contains sulfur, nitrogen, and oxygen heteroatoms within its benzothiophene structure. Specific physical properties such as melting point, boiling point, and solubility characteristics should be verified through technical documentation, as these parameters are critical for proper handling and application in industrial processes.
What is N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine used for?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is primarily used as an intermediate in pharmaceutical and fine chemical synthesis. Its benzothiophene structure makes it valuable for developing pharmaceutical compounds, particularly those targeting specific biological pathways. The compound may also serve as a building block in organic synthesis for creating more complex molecules in research and development applications within the pharmaceutical and specialty chemical industries.
How to handle N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine safely?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. The substance can cause serious eye damage and skin sensitization, so direct contact must be avoided. Always follow GHS safety data sheet recommendations and establish emergency procedures before handling.
How to store N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine correctly?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Keep containers protected from light and moisture to prevent degradation. Storage areas must be equipped with appropriate spill containment measures and emergency equipment. Maintain proper inventory control and ensure containers are properly labeled according to GHS requirements. Regular inspection of storage conditions is essential for product stability.
What to do in case of contact with N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
Immediate action is required if contact occurs with N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine. For eye contact, rinse immediately with plenty of water for at least 15 minutes and seek medical attention due to potential serious eye damage. For skin contact, wash thoroughly with soap and water and remove contaminated clothing. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for specific first aid measures.
How to dispose of N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine appropriately?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine must be disposed of according to local, national, and international environmental regulations as hazardous waste. Contact licensed hazardous waste disposal companies for proper treatment and disposal. The substance cannot be disposed of via regular waste streams due to its toxicological and environmental hazard classification. Maintain detailed waste disposal records and ensure all disposal activities comply with REACH and local environmental protection requirements.
How to transport N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. The substance requires appropriate UN-specification packaging and proper shipping documentation including dangerous goods declarations. Transport vehicles must comply with ADR regulations and carry appropriate emergency information. Only trained personnel should handle transportation arrangements, and all shipments must be properly labeled with hazard identification numbers and emergency contact information.
Is N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine subject to specific regulations?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is subject to European REACH regulation and CLP classification requirements. The substance is classified with multiple hazard categories including acute toxicity, eye damage, skin sensitization, and environmental hazards, requiring comprehensive safety data sheets and risk assessments. While not currently listed as an SVHC substance, users must comply with occupational exposure limits and implement appropriate risk management measures as outlined in the extended safety data sheet.
Where to buy N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine in Europe?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is available through OYSI, a specialized European distributor of technical chemical products. OYSI provides comprehensive technical support, regulatory documentation, and quality assurance for this specialty chemical compound. As an established supplier in the European market, OYSI ensures compliance with REACH registration requirements and provides detailed safety data sheets and certificates of analysis to support your industrial applications and regulatory compliance needs.
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ADR Consulting for N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.