N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine
C10H9NOS
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Identification
- CAS Number
- 147396-08-5
- EC Number
- 410-780-8
- UN Number
- 3077
- Index Number
- 612-157-00-8
- PubChem CID
- 72729745
Physical-chemical properties
- Molecular Formula
- C10H9NOS
- Molar Mass
- 191.25 g/mol
- IUPAC Name
- N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine
Chemical Identifiers
- InChI
- InChI=1S/C10H9NOS/c1-7(11-12)10-6-8-4-2-3-5-9(8)13-10/h2-6,12H,1H3
- InChI Key
- LYNWDHNMGAKITE-UHFFFAOYSA-N
Overview
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine (CAS 147396-08-5) is an oxime compound featuring a benzothiophene ring system with notable chemical reactivity and specific hazard characteristics. This specialized organic compound belongs to the oxime family, characterized by its N-OH functional group attached to a carbon-nitrogen double bond. The molecule incorporates a benzothiophene moiety, which consists of a benzene ring fused to a thiophene ring, providing unique electronic and structural properties. With a molecular formula of C10H9NOS and a molecular weight of 191.25 g/mol, this compound exhibits distinct chemical behavior due to the combination of its heterocyclic sulfur-containing ring system and oxime functionality. The substance presents significant safety considerations, classified under multiple hazard categories including acute toxicity (Category 4), eye damage (Category 1), skin sensitization (Category 1), and specific target organ toxicity following repeated exposure (Category 2). The presence of GHS pictograms including GHS07, GHS08, GHS05, and GHS09 indicates the need for comprehensive safety protocols during handling and storage. Its ADR Class 9 classification requires appropriate transportation precautions as a miscellaneous dangerous substance. In industrial applications, N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine serves primarily as an intermediate in pharmaceutical synthesis and specialty chemical manufacturing. Its oxime functionality makes it valuable for organic transformations and as a building block for more complex molecular structures. The compound shares certain synthetic pathways with related benzothiophene derivatives, though it offers distinct reactivity compared to compounds like 1-(2-amino-5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone hydrochloride. OYSI maintains reliable supply chains for this specialized chemical intermediate, supporting European industrial customers with consistent quality and regulatory compliance.
Safety & Classification
Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 2
GHS Pictograms
Exclamation Mark
GHS07
Harmful. May cause irritation, allergic reactions, or drowsiness.
Health Hazard
GHS08
Serious health hazard. May cause cancer, organ damage, or genetic defects.
Corrosion
GHS05
Corrosive. Causes severe skin burns and eye damage.
Environment
GHS09
Environmental hazard. Toxic to aquatic life with long lasting effects.
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | cis-1-Benzo[b]thien-2-ylethanonoxim-hydrochlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is an organic chemical compound with the molecular formula C10H9NOS and CAS number 147396-08-5. This substance has a molecular weight of 191.25 g/mol and contains a benzothiophene ring system linked to a hydroxylamine functional group through an ethylidene bridge. It is classified as a hazardous substance requiring careful handling due to its toxicological properties and potential environmental impact.
What are the physicochemical properties of N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is a solid organic compound at room temperature with a molecular weight of 191.25 g/mol. The compound contains sulfur, nitrogen, and oxygen heteroatoms within its benzothiophene-based structure. Specific physical properties such as melting point, boiling point, and solubility characteristics should be confirmed through technical documentation, as these parameters are critical for proper handling and application procedures.
What is N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine used for?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is primarily used as a chemical intermediate in organic synthesis and pharmaceutical research applications. Its benzothiophene structure makes it valuable for developing compounds with potential biological activity. The hydroxylamine functionality allows for further chemical modifications in synthetic pathways. Industrial applications may include use in specialty chemical manufacturing and advanced material development, though specific end-uses depend on regulatory approvals and safety assessments.
How to handle N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine safely?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine requires careful handling due to its classification as Acute Tox. 4, Eye Dam. 1, and Skin Sens. 1. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid skin and eye contact completely. Handle quantities carefully and ensure emergency procedures are readily available before beginning work with this substance.
How to store N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine correctly?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine should be stored in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly sealed and properly labeled according to GHS requirements. Storage areas must be equipped with appropriate spill containment measures and emergency equipment. Due to its hazard classification, restrict access to authorized personnel only and maintain inventory records. Check containers regularly for signs of deterioration or leakage.
What to do in case of contact with N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
Immediate action is required upon contact with N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine due to its Eye Dam. 1 and Skin Sens. 1 classifications. For eye contact, flush immediately with plenty of water for at least 15 minutes and seek medical attention urgently. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. If inhaled, move to fresh air immediately. Seek medical advice in all cases of exposure and provide safety data sheet to medical personnel.
How to dispose of N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine appropriately?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine waste must be disposed of through licensed hazardous waste contractors in accordance with local and European regulations. The substance's Aquatic Chronic 2 classification requires special attention to prevent environmental contamination. Do not discharge to sewers, waterways, or soil. Collect waste in appropriate containers, properly labeled with hazard information. Maintain waste disposal records and ensure compliance with REACH and national waste management regulations.
How to transport N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. Packages must be properly labeled with appropriate hazard markings and UN identification numbers. Use approved packaging materials and ensure compliance with ADR regulations for road transport within Europe. Transportation documents must include proper shipping names and emergency response information. Only qualified carriers experienced in handling hazardous materials should transport this substance.
Is N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine subject to specific regulations?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is subject to European REACH and CLP regulations due to its hazardous properties. While not currently identified as a SVHC (Substance of Very High Concern), its toxicological profile requires compliance with occupational exposure limits and risk assessment procedures. Users must ensure proper registration status and follow safety data sheet requirements. National regulations may impose additional restrictions on handling, storage, and use of this substance.
Where to buy N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine in Europe?
N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this substance with complete regulatory documentation including safety data sheets and certificates of analysis. As a professional chemical distributor, OYSI ensures compliance with European regulations and provides technical support for safe handling and application. Contact OYSI directly for availability, specifications, and regulatory information specific to your intended use and location.
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N-[1-(1-benzothiophen-2-yl)ethylidene]hydroxylamine is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.