2,4-dinitrophenol

C6H4N2O5

CAS51-28-5
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
51-28-5
EC Number
200-087-7
UN Number
0076
Index Number
609-041-00-4
PubChem CID
1493

Physical-chemical properties

Molecular Formula
C6H4N2O5
Molar Mass
184.11 g/mol
IUPAC Name
2,4-dinitrophenol

Chemical Identifiers

InChI
InChI=1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H
InChI Key
UFBJCMHMOXMLKC-UHFFFAOYSA-N

Overview

2,4-dinitrophenol (CAS 51-28-5) is a highly toxic nitrophenol compound with explosive properties and potent biological activity. 2,4-dinitrophenol, commonly abbreviated as DNP, represents a significant nitroaromatic compound characterized by two nitro groups positioned at the 2 and 4 positions on a phenol ring. With the molecular formula C6H4N2O5 and a molecular weight of 184.11 g/mol, this yellow crystalline substance exhibits remarkable chemical reactivity and biological potency that demands careful handling protocols. The compound's classification under ADR Class 1 reflects its explosive nature, while its comprehensive hazard profile includes acute toxicity categories ranging from 2 to 3, specific target organ toxicity, and acute aquatic toxicity. The presence of GHS06, GHS08, and GHS09 pictograms emphasizes the critical safety considerations required when working with this material, particularly regarding its potential for severe health effects and environmental impact. DNP's unique mechanism involves uncoupling oxidative phosphorylation in cellular mitochondria, making it historically significant in biochemical research and metabolic studies. This property, while scientifically valuable, contributes to its high toxicity profile. The compound shares structural similarities with other nitroaromatic compounds such as 2,3-dinitrophenol, though each exhibits distinct reactivity patterns and safety profiles. Industrial applications primarily focus on chemical synthesis as an intermediate, particularly in the production of dyes, explosives, and specialized organic compounds. Research laboratories utilize DNP in biochemical studies investigating cellular metabolism and as a reagent in analytical chemistry applications. OYSI maintains availability of 2,4-dinitrophenol through established supply channels, ensuring proper handling, documentation, and regulatory compliance for qualified industrial and research customers requiring this specialized chemical compound.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3; Acute Tox. 2; STOT RE 1; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H300

Fatal if swallowed.

H372

Causes damage to organs through prolonged or repeated exposure.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Fatal

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number0076
ADR Class1
Packing Group
Tunnel CodeB1000C
Proper Shipping Name2,4-Dinitrophenol, trocken, nicht pulverförmig
Marine PollutantNo

Frequently Asked Questions

What is 2,4-dinitrophenol?

2,4-dinitrophenol is an organic chemical compound with the molecular formula C6H4N2O5 and CAS number 51-28-5. This nitrophenol derivative has a molecular weight of 184.11 g/mol and belongs to the class of dinitrophenols. It is classified as a highly toxic substance with significant health and environmental hazards, requiring strict handling protocols and safety measures during use.

What are the physicochemical properties of 2,4-dinitrophenol?

2,4-dinitrophenol is typically a yellow crystalline solid at room temperature with a characteristic phenolic odor. It exhibits moderate solubility in water and higher solubility in organic solvents such as alcohol and ether. The compound has a melting point around 108-112°C and is sensitive to heat, shock, and friction due to its explosive nature, making proper handling essential.

What is 2,4-dinitrophenol used for?

2,4-dinitrophenol is primarily used as an intermediate in the synthesis of dyes, pesticides, and other organic chemicals. It serves as a precursor for manufacturing certain herbicides and fungicides. Additionally, it finds application in analytical chemistry as a reagent and in research laboratories for biochemical studies. Its use is highly regulated due to its toxic and explosive properties.

How to handle 2,4-dinitrophenol safely?

2,4-dinitrophenol must be handled with extreme caution using appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Avoid contact with skin, eyes, and clothing. Use non-sparking tools and eliminate all ignition sources due to its explosive nature and high toxicity.

How to store 2,4-dinitrophenol correctly?

2,4-dinitrophenol should be stored in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and incompatible materials. Keep containers tightly sealed and store separately from reducing agents, metals, and organic materials. The storage area must be equipped with appropriate fire suppression systems and emergency response equipment due to its explosive and toxic properties.

What to do in case of contact with 2,4-dinitrophenol?

In case of skin contact with 2,4-dinitrophenol, immediately remove contaminated clothing and wash affected areas thoroughly with soap and water for at least 15 minutes. For eye contact, flush with clean water for 15 minutes. If inhaled, move to fresh air immediately. Seek immediate medical attention in all cases of exposure, as this substance is highly toxic and can cause severe health effects.

How to dispose of 2,4-dinitrophenol properly?

2,4-dinitrophenol waste must be disposed of through licensed hazardous waste disposal facilities in accordance with local and national environmental regulations. It cannot be disposed of in regular waste streams due to its toxic and explosive properties. Contact certified waste management companies specializing in hazardous chemical disposal and follow all applicable waste classification and transportation requirements.

How to transport 2,4-dinitrophenol?

2,4-dinitrophenol is classified under ADR Class 1 as an explosive substance, requiring specialized transportation procedures. It must be packaged in approved containers according to dangerous goods regulations and transported by qualified carriers with proper documentation. All transport vehicles must comply with ADR requirements for explosive materials, including appropriate labeling, placarding, and emergency response information.

Is 2,4-dinitrophenol subject to specific regulations?

2,4-dinitrophenol is subject to strict regulations under REACH and CLP in Europe due to its high toxicity and explosive properties. It requires safety data sheets, hazard classification, and proper labeling with GHS pictograms GHS06, GHS08, and GHS09. The substance may be subject to authorization or restriction procedures and requires compliance with occupational exposure limits and environmental protection measures.

Where to buy 2,4-dinitrophenol in Europe?

2,4-dinitrophenol can be purchased from OYSI, a specialized European distributor of technical chemicals. As a professional supplier, OYSI ensures compliance with all regulatory requirements and provides proper documentation including safety data sheets. Due to the substance's hazardous nature, purchases are typically restricted to qualified industrial users with appropriate handling and storage capabilities.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.