2,4-dinitrophenol

C6H4N2O5

CAS51-28-5
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
51-28-5
EC Number
200-087-7
UN Number
0076
Index Number
609-041-00-4
PubChem CID
1493

Physical-chemical properties

Molecular Formula
C6H4N2O5
Molar Mass
184.11 g/mol
IUPAC Name
2,4-dinitrophenol

Chemical Identifiers

InChI
InChI=1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H
InChI Key
UFBJCMHMOXMLKC-UHFFFAOYSA-N

Overview

2,4-dinitrophenol (CAS 51-28-5) is a nitroaromatic compound with explosive properties and high toxicity to humans and aquatic organisms. This yellow crystalline solid represents one of the most hazardous chemicals in industrial applications, requiring exceptional safety protocols throughout its handling, storage, and transportation. As a dinitrophenol derivative, 2,4-dinitrophenol exhibits both the characteristic properties of phenolic compounds and the dangerous nature of nitroaromatic explosives. The compound's classification under ADR Class 1 reflects its explosive potential, while multiple acute toxicity classifications and the STOT RE 1 designation underscore its severe health risks, including potential for systemic organ damage through repeated exposure. The chemical structure features two nitro groups positioned at the 2 and 4 positions on the phenol ring, creating a highly reactive and energetic molecule. Unlike related compounds such as 2,3-dinitrophenol, the specific positioning of nitro groups in 2,4-dinitrophenol contributes to its particular explosive characteristics and toxicological profile. This positioning also influences its chemical reactivity and industrial utility compared to other nitroaromatic compounds like 2-methyl-1,3,5-trinitrobenzene. Industrial applications of 2,4-dinitrophenol include its use as an intermediate in the synthesis of dyes, pesticides, and other specialty chemicals. The compound also finds application in analytical chemistry as a derivatizing agent and in certain manufacturing processes requiring its unique chemical properties. However, all applications must account for its extreme hazard profile and regulatory restrictions. OYSI maintains strict protocols for the supply of 2,4-dinitrophenol, ensuring compliance with all European safety and transportation regulations while supporting legitimate industrial requirements.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3; Acute Tox. 2; STOT RE 1; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H300

Fatal if swallowed.

H372

Causes damage to organs through prolonged or repeated exposure.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Fatal

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number0076
ADR Class1
Packing Group
Tunnel CodeB1000C
Proper Shipping Name2,4-Dinitrophenol, trocken, nicht pulverförmig
Marine PollutantNo

Frequently Asked Questions

What is 2,4-dinitrophenol?

2,4-dinitrophenol is an organic chemical compound with the molecular formula C6H4N2O5 and CAS number 51-28-5. This nitrophenol derivative has a molecular weight of 184.11 g/mol and appears as yellow crystalline solid. It is classified as a highly hazardous substance with multiple toxicity concerns, including acute toxicity and specific target organ toxicity. The compound is regulated under various safety frameworks due to its dangerous properties.

What are the physicochemical properties of 2,4-dinitrophenol?

2,4-dinitrophenol is a yellow crystalline solid at room temperature with a distinctive phenolic structure. The compound is moderately soluble in water and readily dissolves in organic solvents like ethanol and acetone. It has a melting point around 108-112°C and exhibits acidic properties due to its phenolic hydroxyl group. The presence of two nitro groups makes it highly reactive and contributes to its hazardous nature.

What is 2,4-dinitrophenol used for?

2,4-dinitrophenol is primarily used as a chemical intermediate in the synthesis of dyes, pesticides, and other organic compounds. It serves as a precursor for manufacturing various industrial chemicals and has applications in analytical chemistry as a reagent. The compound is also used in research laboratories for biochemical studies. Due to its hazardous properties, its industrial applications are strictly regulated and require specialized handling procedures.

How to handle 2,4-dinitrophenol safely?

Safe handling of 2,4-dinitrophenol requires comprehensive personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin contact and ensure all personnel are trained in emergency procedures. The compound's Acute Tox. 2/3 classification demands strict adherence to safety protocols and immediate access to emergency equipment.

How to store 2,4-dinitrophenol correctly?

2,4-dinitrophenol must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. The compound should be kept in tightly sealed, properly labeled containers made of compatible materials. Storage areas must be equipped with appropriate containment measures and fire suppression systems. Due to its explosive classification (ADR Class 1), special storage requirements apply, including quantity limitations and segregation from other hazardous materials.

What to do in case of contact with 2,4-dinitrophenol?

Immediate action is required for any contact with 2,4-dinitrophenol due to its high toxicity. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. For eye contact, flush with clean water for 15 minutes. In all cases of exposure, contact emergency medical services immediately and provide them with the safety data sheet information.

How to dispose of 2,4-dinitrophenol properly?

2,4-dinitrophenol disposal must comply with local and international hazardous waste regulations due to its acute toxicity and environmental hazard classification. The compound requires specialized treatment through licensed hazardous waste disposal facilities equipped to handle explosive and toxic materials. Incineration at high temperatures in approved facilities is typically required. Never dispose of this substance through regular waste streams or drain systems due to its Aquatic Acute 1 classification.

How to transport 2,4-dinitrophenol?

2,4-dinitrophenol is classified under ADR Class 1 as an explosive substance, requiring specialized transport procedures and documentation. Transportation must comply with dangerous goods regulations, including proper packaging, labeling with GHS06, GHS08, and GHS09 pictogrammes, and appropriate shipping papers. Only certified carriers qualified for explosive materials transport should handle shipments. Special routing and quantity restrictions may apply depending on local regulations.

Is 2,4-dinitrophenol subject to special regulations?

2,4-dinitrophenol is subject to extensive regulatory oversight under REACH, CLP, and other chemical safety frameworks. The compound's multiple hazard classifications (Acute Tox. 2/3, STOT RE 1, Aquatic Acute 1) trigger strict registration, notification, and handling requirements. While not currently listed as an SVHC, its dangerous properties mean it may face additional restrictions. Companies must maintain detailed safety documentation and ensure compliance with all applicable chemical safety regulations.

Where to buy 2,4-dinitrophenol in Europe?

2,4-dinitrophenol is available through specialized chemical distributors like OYSI, which serves the European market with professional-grade chemicals. Due to the compound's hazardous classification and regulatory requirements, purchases are typically restricted to qualified industrial users and research institutions. Buyers must demonstrate proper handling capabilities, storage facilities, and regulatory compliance. Contact OYSI's technical team for availability, specifications, and regulatory documentation requirements for your specific application.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.