2,2,2-trifluoroacetyl chloride

2,2,2-trifluoroacetyl chloride is a highly reactive organofluorine compound with the molecular formula C2ClF3O and CAS number 354-32-5. This acyl chloride features three fluorine atoms attached to the methyl carbon, making it a trifluorinated derivative of acetyl chloride. With a molecular weight of 132.47 g/mol, it serves as an important building block in fluorine chemistry and pharmaceutical synthesis due to its ability to introduce trifluoroacetyl groups into organic molecules.

2,2,2-trifluoroacetyl chloride is a colorless liquid at room temperature with a pungent, acrid odor characteristic of acyl chlorides. It has a boiling point of approximately 27-28°C and a density of about 1.48 g/cm³. The compound is highly reactive with water, undergoing rapid hydrolysis to form trifluoroacetic acid and hydrogen chloride. It is soluble in organic solvents but decomposes in the presence of moisture, making it essential to handle under anhydrous conditions.

2,2,2-trifluoroacetyl chloride is primarily used as an acylating agent in organic synthesis to introduce trifluoroacetyl protecting groups in amino acids and peptides. It serves as a key intermediate in pharmaceutical manufacturing, particularly in the synthesis of fluorinated drugs and agrochemicals. The compound is also utilized in analytical chemistry for derivatization reactions, helping to improve the volatility and detectability of compounds in gas chromatography and mass spectrometry applications.

2,2,2-trifluoroacetyl chloride must be handled in a well-ventilated fume hood using appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and lab coat. Work should be conducted under anhydrous conditions to prevent violent hydrolysis reactions. Avoid contact with skin, eyes, and inhalation of vapors. Use proper handling techniques for corrosive materials and ensure emergency shower and eyewash stations are accessible. Always work with small quantities and have appropriate neutralizing agents available.

2,2,2-trifluoroacetyl chloride should be stored in tightly sealed containers under anhydrous conditions in a cool, dry, well-ventilated area away from moisture and heat sources. Keep containers in secondary containment to prevent spills and store away from incompatible materials such as water, alcohols, amines, and strong bases. Use amber glass bottles or other suitable chemical-resistant containers. Maintain storage temperature below 25°C and ensure proper labeling with hazard information and expiration dates.

In case of skin contact with 2,2,2-trifluoroacetyl chloride, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. For eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air and provide respiratory support if needed. In case of ingestion, do not induce vomiting and seek immediate medical care. Always consult a physician after any exposure incident.

2,2,2-trifluoroacetyl chloride must be disposed of as hazardous chemical waste according to local and national regulations. Small quantities can be carefully hydrolyzed under controlled conditions in a fume hood, neutralized, and then disposed of through authorized waste management companies. Never dispose of this compound down drains or in regular waste. Contact certified hazardous waste disposal services and ensure proper documentation. Follow your institution's chemical waste management protocols and maintain disposal records.

2,2,2-trifluoroacetyl chloride is classified under ADR Class 2 for transport purposes, indicating it falls under gases or gas-related materials regulations. Transportation must comply with dangerous goods regulations using appropriate packaging, labeling, and documentation. Use UN-specification packaging suitable for corrosive liquids and ensure proper hazard placarding. Transport should be conducted by certified carriers familiar with chemical transport regulations. Maintain proper shipping papers and emergency response information during transit.

2,2,2-trifluoroacetyl chloride is subject to REACH regulation in Europe and must be registered for commercial use above specified tonnage thresholds. It is not currently listed as an SVHC (Substance of Very High Concern) but users must comply with CLP regulation for classification, labeling, and packaging. Industrial users should conduct chemical safety assessments and implement appropriate risk management measures. Export/import may require additional permits depending on destination countries and quantities involved.

2,2,2-trifluoroacetyl chloride is available through OYSI, a trusted European distributor of specialty chemicals and intermediates. As an established chemical supplier, OYSI provides high-quality 2,2,2-trifluoroacetyl chloride with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly for pricing, availability, packaging options, and delivery throughout Europe. We ensure proper handling, packaging, and transport of this reactive compound while maintaining the highest quality and safety standards for our customers.