2-methoxyethyl acetate

C5H10O3

CAS110-49-6
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
Danger

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Identification

CAS Number
110-49-6
EC Number
203-772-9
UN Number
1189
Index Number
607-036-00-1
PubChem CID
8054

Physical-chemical properties

Molecular Formula
C5H10O3
Molar Mass
118.13 g/mol
IUPAC Name
2-methoxyethyl acetate

Chemical Identifiers

InChI
InChI=1S/C5H10O3/c1-5(6)8-4-3-7-2/h3-4H2,1-2H3
InChI Key
XLLIQLLCWZCATF-UHFFFAOYSA-N

Overview

2-methoxyethyl acetate (CAS 110-49-6) is an organic solvent and glycol ether acetate with excellent solvency properties and moderate volatility. This colorless liquid represents an important member of the glycol ether acetate family, combining the beneficial characteristics of both ether and ester functionalities. As a derivative of ethylene glycol monomethyl ether, 2-methoxyethyl acetate offers superior dissolution capabilities for a wide range of organic compounds, making it valuable across multiple industrial applications. With its molecular formula C5H10O3 and molecular weight of 118.13 g/mol, this compound exhibits excellent compatibility with various resin systems and provides controlled evaporation rates in formulated products. The substance requires careful handling due to its classification as a reproductive toxicant category 1B under the GHS system, indicated by the danger signal word and GHS08 health hazard pictogram. Additional acute toxicity classifications necessitate appropriate workplace safety measures and personal protective equipment during handling and processing operations. Primary industrial applications include use as a solvent in coating formulations, printing inks, and specialty chemical manufacturing processes where controlled evaporation and excellent solvency are required. Unlike simpler aromatic solvents such as ethylbenzene, 2-methoxyethyl acetate provides enhanced polarity and compatibility with polar substrates. The compound also serves as an intermediate in pharmaceutical synthesis and as a component in electronic cleaning applications where precision and purity are essential. OYSI maintains reliable supply chains for 2-methoxyethyl acetate, supporting European industrial customers with consistent quality and comprehensive technical documentation to ensure safe and effective implementation in their manufacturing processes.

Safety & Classification

Danger
Classification:

Repr. 1B; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1189
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping NameEthylenglycolmonomethyletheracetat
Marine PollutantNo

Frequently Asked Questions

What is 2-methoxyethyl acetate?

2-methoxyethyl acetate is an organic solvent belonging to the glycol ether acetate family, with the chemical formula C5H10O3 and CAS number 110-49-6. This compound has a molecular weight of 118.13 g/mol and is classified as a reproductive toxicant category 1B and acute toxicant category 4. It appears as a colorless liquid with a mild ester-like odor and exhibits good solvency properties for various organic materials.

What are the physicochemical properties of 2-methoxyethyl acetate?

2-methoxyethyl acetate is a colorless liquid at room temperature with a characteristic mild, sweet ester-like odor. It has good solubility in both polar and non-polar solvents, making it an excellent coupling agent. The compound is miscible with most organic solvents and has moderate water solubility. It exhibits typical ester properties and can undergo hydrolysis under acidic or basic conditions.

What is 2-methoxyethyl acetate used for?

2-methoxyethyl acetate is primarily used as a high-performance solvent in industrial coatings, inks, and adhesives formulations. It serves as a coupling agent in water-based systems and as a coalescent in latex paints. The compound is also utilized in electronics manufacturing for cleaning applications and in the production of specialty chemicals. Its excellent solvency properties make it valuable for dissolving resins, polymers, and other organic compounds.

How to handle 2-methoxyethyl acetate safely?

2-methoxyethyl acetate must be handled with extreme caution due to its reproductive toxicity classification (Repr. 1B). Use appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Ensure adequate ventilation and avoid skin contact and inhalation. Pregnant workers should avoid exposure entirely. Work in well-ventilated areas or under fume hoods, and implement proper hygiene measures including hand washing after handling.

How to store 2-methoxyethyl acetate correctly?

2-methoxyethyl acetate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition sources. Keep containers away from incompatible materials such as strong oxidizing agents and strong acids or bases. Store in original containers with proper labeling and ensure temperature control to prevent vapor buildup. Implement appropriate fire prevention measures due to its flammable nature (ADR Class 3).

What to do in case of contact with 2-methoxyethyl acetate?

In case of skin contact with 2-methoxyethyl acetate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush with clean water for 15 minutes and seek medical attention. In case of inhalation, move to fresh air immediately. If ingested, do not induce vomiting and seek immediate medical attention. Always consult a physician and provide the safety data sheet.

How to dispose of 2-methoxyethyl acetate properly?

2-methoxyethyl acetate must be disposed of as hazardous waste according to local and European regulations. Do not dispose of in regular waste streams or pour down drains due to its toxicity classification. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Ensure proper waste classification and documentation. Empty containers should also be treated as hazardous waste unless properly decontaminated according to regulatory requirements.

How to transport 2-methoxyethyl acetate?

2-methoxyethyl acetate is classified under ADR as Class 3 (flammable liquids), Packing Group III for transportation purposes. It requires appropriate UN packaging and labeling according to dangerous goods regulations. Vehicles must carry proper documentation, emergency response information, and appropriate fire extinguishing equipment. Drivers need ADR certification, and transport must comply with routing restrictions and tunnel regulations applicable to Class 3 substances.

Is 2-methoxyethyl acetate subject to specific regulations?

2-methoxyethyl acetate is subject to REACH registration requirements and CLP classification as a reproductive toxicant category 1B and acute toxicant category 4. While not currently listed as an SVHC, its reproductive toxicity classification subjects it to strict workplace exposure controls and potential authorization requirements. Users must comply with occupational health regulations, particularly regarding pregnant workers, and follow appropriate risk management measures outlined in safety data sheets.

Where to buy 2-methoxyethyl acetate in Europe?

2-methoxyethyl acetate is available through OYSI, a specialized European distributor of industrial chemicals. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support. As experienced chemical suppliers, they ensure proper packaging, labeling, and delivery throughout Europe while maintaining strict quality standards and providing technical support for safe handling and application of this specialized solvent.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.