2-methylpropyl nitrite

C4H9NO2

CAS542-56-3
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
Danger

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Identification

CAS Number
542-56-3
EC Number
208-819-7
UN Number
2351
Index Number
007-017-00-2
PubChem CID
10958

Physical-chemical properties

Molecular Formula
C4H9NO2
Molar Mass
103.12 g/mol
IUPAC Name
2-methylpropyl nitrite

Chemical Identifiers

InChI
InChI=1S/C4H9NO2/c1-4(2)3-7-5-6/h4H,3H2,1-2H3
InChI Key
APNSGVMLAYLYCT-UHFFFAOYSA-N

Overview

2-methylpropyl nitrite (CAS 542-56-3) is an organic nitrite ester with significant industrial applications and notable safety considerations. This chemical compound, also identified by EC number 208-819-7, belongs to the family of alkyl nitrites and exhibits the molecular formula C4H9NO2 with a molecular weight of 103.12 g/mol. As a volatile organic compound, 2-methylpropyl nitrite demonstrates characteristic properties typical of nitrite esters, including its classification as a flammable liquid under Category 2 regulations. The substance requires careful handling due to its comprehensive hazard profile, which includes carcinogenic properties (Category 1B), mutagenic potential (Category 2), and acute toxicity (Category 4). The compound's safety profile necessitates strict adherence to handling protocols, as indicated by its "Danger" signal word and multiple GHS pictograms (GHS02, GHS07, GHS08). Its classification under ADR Class 3 further emphasizes the flammable nature of this material, requiring specialized storage and transportation procedures. Unlike related compounds such as ethylbenzene or styrene, which find extensive use in polymer production, 2-methylpropyl nitrite serves more specialized industrial functions. Primary industrial applications include its use as a chemical intermediate in organic synthesis processes and as a specialty reagent in pharmaceutical manufacturing. The compound also finds application in certain analytical chemistry procedures where nitrite esters are required for specific reactions or transformations. OYSI maintains reliable supply chains for 2-methylpropyl nitrite, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Carc. 1B; Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H350

May cause cancer.

H341

Suspected of causing genetic defects.

H332

Harmful if inhaled.

H302

Harmful if swallowed.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2351
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameIsobutylnitrit
Marine PollutantNo

Frequently Asked Questions

What is 2-methylpropyl nitrite?

2-methylpropyl nitrite is an organic chemical compound with the molecular formula C4H9NO2 and CAS number 542-56-3. It belongs to the alkyl nitrite family and has a molecular weight of 103.12 g/mol. This substance is classified as a flammable liquid with significant health hazards including carcinogenic and mutagenic properties. It requires careful handling due to its acute toxicity and is regulated under various safety classifications including GHS pictograms for flammability, health hazards, and irritation.

What are the physicochemical properties of 2-methylpropyl nitrite?

2-methylpropyl nitrite is a volatile organic liquid at room temperature with characteristic properties typical of alkyl nitrites. As an ester of nitrous acid, it exhibits flammable properties classified under Flam. Liq. 2 category. The compound has a molecular mass of 103.12 g/mol and contains four carbon atoms in its branched structure. Its volatile nature and organic composition make it soluble in organic solvents while being relatively unstable, requiring controlled storage conditions.

What is 2-methylpropyl nitrite used for?

2-methylpropyl nitrite is primarily used as a chemical intermediate in organic synthesis and pharmaceutical manufacturing processes. Its nitrite functional group makes it valuable in specific chemical reactions where nitrosation or nitrite transfer is required. Due to its hazardous classification including carcinogenic properties, its industrial applications are strictly controlled and limited to professional settings with appropriate safety measures. The compound requires specialized handling procedures and is typically used only in well-ventilated laboratory or industrial environments.

How to handle 2-methylpropyl nitrite safely?

2-methylpropyl nitrite requires strict safety protocols due to its Danger signal word and multiple hazard classifications. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Given its flammable nature (Flam. Liq. 2) and acute toxicity, eliminate all ignition sources and avoid skin contact or inhalation. Work in fume hoods when possible, and ensure emergency eyewash and shower facilities are accessible. Only trained personnel should handle this carcinogenic substance.

How to store 2-methylpropyl nitrite correctly?

2-methylpropyl nitrite must be stored in a cool, dry, well-ventilated area away from heat sources and ignition points due to its Flam. Liq. 2 classification. Use appropriate chemical storage cabinets designed for flammable liquids with secondary containment. Keep containers tightly sealed to prevent evaporation and degradation. Store away from incompatible materials including strong oxidizers and reducing agents. Maintain storage temperature below recommended limits and ensure proper labeling with GHS02, GHS07, and GHS08 pictograms for safety identification.

What to do in case of contact with 2-methylpropyl nitrite?

Immediate action is required upon contact with 2-methylpropyl nitrite due to its acute toxicity classification. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. For eye contact, flush with clean water for 15 minutes while holding eyelids open. If ingested, do not induce vomiting and seek immediate medical attention. Always inform medical personnel about the substance's carcinogenic and mutagenic properties.

How to dispose of 2-methylpropyl nitrite properly?

2-methylpropyl nitrite must be disposed of through licensed hazardous waste disposal facilities due to its carcinogenic classification and flammable properties. Never dispose of this substance down drains or in regular waste streams. Container disposal requires special handling as empty containers may retain hazardous residues. Follow local and European waste regulations (EWC codes) for organic chemical waste. Incineration must be performed at authorized facilities capable of handling carcinogenic materials with appropriate emission controls and temperature requirements.

How to transport 2-methylpropyl nitrite?

2-methylpropyl nitrite is classified under ADR Class 3 (Flammable Liquids), Packing Group II, requiring specialized transport procedures. Packages must comply with UN packaging standards for dangerous goods and bear proper hazard labels including flammable liquid markings. Transport vehicles need appropriate placarding and emergency equipment. Drivers require ADR certification for Class 3 substances. Documentation must include proper shipping names, hazard classifications, and emergency response information. Only authorized carriers experienced in dangerous goods transport should handle shipments of this substance.

Is 2-methylpropyl nitrite subject to special regulations?

2-methylpropyl nitrite is subject to extensive European chemical regulations including REACH registration requirements and CLP classification obligations. Its Carc. 1B and Muta. 2 classifications trigger strict workplace exposure limits and reporting requirements. While not currently listed as an SVHC, its carcinogenic properties may subject it to authorization procedures. Industrial users must implement risk management measures and provide safety data sheets. Transport requires ADR compliance, and occupational exposure is regulated under health and safety directives requiring medical surveillance programs.

Where to buy 2-methylpropyl nitrite in Europe?

2-methylpropyl nitrite is available through specialized European chemical distributors like OYSI, which supplies industrial chemicals across Europe. Due to its hazardous classification and regulatory requirements, this substance is only supplied to qualified industrial customers with appropriate handling capabilities. Purchasers must demonstrate legitimate industrial use and compliance with safety regulations. OYSI provides proper documentation including safety data sheets and ensures compliant packaging and transport. Contact OYSI's technical team for availability, specifications, and regulatory guidance for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.