2,3-dichloroprop-1-ene

C3H4Cl2

CAS78-88-6
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
78-88-6
EC Number
201-153-8
UN Number
2047
Index Number
602-079-00-2
PubChem CID
6565

Physical-chemical properties

Molecular Formula
C3H4Cl2
Molar Mass
110.97 g/mol
IUPAC Name
2,3-dichloroprop-1-ene

Chemical Identifiers

InChI
InChI=1S/C3H4Cl2/c1-3(5)2-4/h1-2H2
InChI Key
FALCMQXTWHPRIH-UHFFFAOYSA-N

Overview

2,3-dichloroprop-1-ene (CAS 78-88-6) is an organochlorine compound with flammable and mutagenic properties used in industrial chemical synthesis. This halogenated alkene represents a versatile intermediate in organic chemistry, characterized by its reactive double bond and two strategically positioned chlorine atoms. The compound exhibits significant reactivity due to its unsaturated carbon framework combined with the electron-withdrawing effects of the halogen substituents, making it valuable for various synthetic transformations in industrial processes. From a safety perspective, 2,3-dichloroprop-1-ene requires careful handling protocols due to its classification as a flammable liquid (Category 2) and mutagen (Category 2). The substance presents multiple hazard profiles including acute toxicity through various exposure routes and potential for skin irritation. Its ADR Class 3 classification necessitates specialized transportation and storage procedures, while the presence of GHS pictogrammes GHS02, GHS08, GHS07, and GHS05 indicates the need for comprehensive risk management strategies including appropriate personal protective equipment and ventilation systems. Industrial applications primarily center around its role as a chemical intermediate in pharmaceutical synthesis, agrochemical production, and specialty polymer manufacturing. The compound's electrophilic nature makes it particularly useful in nucleophilic substitution reactions and cycloaddition processes. In some synthetic pathways, it may be used alongside related compounds such as 2-(prop-2-enoxymethyl)oxirane for complex organic transformations. The molecular structure C3H4Cl2 with a molecular weight of 110.97 g/mol provides optimal reactivity-to-stability ratios for controlled industrial processes. Quality control parameters typically focus on purity levels and halogen content analysis to ensure consistent performance in downstream applications. OYSI maintains reliable supply chains for 2,3-dichloroprop-1-ene to support European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; ...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H341

Suspected of causing genetic defects.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H315

Causes skin irritation.

H318

Causes serious eye damage.

H412

Harmful to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2047
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name2,3-Dichlor-1-propen
Marine PollutantNo

Frequently Asked Questions

What is 2,3-dichloroprop-1-ene?

2,3-dichloroprop-1-ene is an organochlorine compound with the molecular formula C3H4Cl2 and CAS number 78-88-6. This chemical substance has a molecular weight of 110.97 g/mol and belongs to the class of halogenated alkenes. It is classified as a flammable liquid with mutagenic properties and various toxicity concerns. The compound is considered hazardous due to its multiple danger classifications including acute toxicity, skin irritation, and specific target organ toxicity.

What are the physicochemical properties of 2,3-dichloroprop-1-ene?

2,3-dichloroprop-1-ene is a flammable liquid at room temperature, as indicated by its classification as Flam. Liq. 2. The compound contains two chlorine atoms attached to a propene backbone, making it a halogenated alkene. Due to its chemical structure, it exhibits properties typical of organochlorine compounds. The substance requires careful handling due to its flammable nature and potential for vapor formation. Specific physical properties such as boiling point, density, and solubility should be referenced from detailed safety data sheets.

What is 2,3-dichloroprop-1-ene used for?

2,3-dichloroprop-1-ene is primarily used as an industrial chemical intermediate in organic synthesis processes. Its applications typically involve chemical manufacturing where halogenated compounds are required as building blocks for more complex molecules. The compound may be utilized in pharmaceutical intermediates, agrochemical synthesis, or specialty chemical production. Due to its hazardous classification and mutagenic properties, its use is restricted to professional industrial applications with appropriate safety measures and regulatory compliance.

How to handle 2,3-dichloroprop-1-ene safely?

2,3-dichloroprop-1-ene requires strict safety protocols due to its multiple hazard classifications. Personal protective equipment must include chemical-resistant gloves, safety goggles, and appropriate respiratory protection to prevent inhalation exposure. Work should be conducted in well-ventilated areas or under fume extraction systems. Avoid contact with skin and eyes, and prevent vapor inhalation. Keep away from ignition sources due to its flammable nature. Emergency shower and eyewash facilities should be readily accessible when handling this substance.

How to store 2,3-dichloroprop-1-ene correctly?

2,3-dichloroprop-1-ene must be stored in a cool, dry, well-ventilated area away from heat sources and ignition points due to its Flam. Liq. 2 classification. Use appropriate chemical-resistant containers and ensure proper labeling with hazard pictogrammes GHS02, GHS08, GHS07, and GHS05. Storage areas should have fire suppression systems and spill containment measures. Keep containers tightly sealed to prevent vapor escape and avoid storage near incompatible materials. Temperature control and regular container inspection are essential for safe storage.

What to do in case of contact with 2,3-dichloroprop-1-ene?

In case of skin contact with 2,3-dichloroprop-1-ene, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet and contact poison control centers when exposure occurs.

How to dispose of 2,3-dichloroprop-1-ene appropriately?

2,3-dichloroprop-1-ene must be disposed of as hazardous waste through licensed waste management facilities in accordance with local, national, and European regulations. The substance cannot be disposed of through regular waste streams due to its toxic and mutagenic properties. Incineration at authorized high-temperature facilities is typically the preferred disposal method. Empty containers should also be treated as hazardous waste. Always consult local environmental authorities and waste management regulations before disposal to ensure full regulatory compliance.

How to transport 2,3-dichloroprop-1-ene?

2,3-dichloroprop-1-ene is classified under ADR Class 3 (flammable liquids), Packing Group II, requiring specialized transport procedures for dangerous goods. Transportation must comply with ADR regulations including proper packaging, labeling, and documentation. Vehicles must display appropriate hazard placards and carry emergency response information. Drivers require ADR certification for dangerous goods transport. The substance must be packaged in UN-approved containers with proper hazard labels including the flammable liquid designation and other applicable pictogrammes.

Is 2,3-dichloroprop-1-ene subject to particular regulations?

2,3-dichloroprop-1-ene is subject to extensive European chemical regulations including REACH registration requirements and CLP classification obligations. The substance's mutagenic classification (Muta. 2) may trigger additional restrictions under various regulatory frameworks. While not currently listed as an SVHC, its hazardous properties require compliance with occupational exposure limits and industrial emissions regulations. Users must maintain safety data sheets, conduct risk assessments, and implement appropriate risk management measures. Regular regulatory updates should be monitored as restrictions may evolve.

Where to buy 2,3-dichloroprop-1-ene in Europe?

2,3-dichloroprop-1-ene is available through OYSI, a specialized European distributor of technical chemicals and industrial raw materials. OYSI provides this regulated chemical substance to qualified industrial customers with proper documentation and regulatory compliance support. Due to the substance's hazardous classification and regulatory requirements, purchases are restricted to professional users with demonstrated technical expertise and appropriate handling facilities. Contact OYSI directly for availability, technical specifications, and regulatory guidance for your specific industrial application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.