2-hydroxybenzoic acid
C7H6O3
Consulting for 2-hydroxybenzoic acid
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Identification
- CAS Number
- 69-72-7
- EC Number
- 200-712-3
- UN Number
- Index Number
- 607-732-00-5
- PubChem CID
- 338
Physical-chemical properties
- Molecular Formula
- C7H6O3
- Molar Mass
- 138.12 g/mol
- IUPAC Name
- 2-hydroxybenzoic acid
Chemical Identifiers
- InChI
- InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
- InChI Key
- YGSDEFSMJLZEOE-UHFFFAOYSA-N
Overview
2-hydroxybenzoic acid (CAS 69-72-7) is an aromatic carboxylic acid featuring both hydroxyl and carboxyl functional groups on a benzene ring structure. Also known as salicylic acid, this white crystalline compound serves as a fundamental building block in pharmaceutical and chemical industries. With the molecular formula C7H6O3 and a molecular weight of 138.12 g/mol, 2-hydroxybenzoic acid exhibits unique chemical properties due to its ortho-positioned hydroxyl and carboxyl groups, enabling intramolecular hydrogen bonding that influences its reactivity and solubility characteristics. The substance presents significant safety considerations, classified under GHS with reproductive toxicity category 2, acute toxicity category 4, and serious eye damage category 1. The danger signal word and associated pictograms GHS08, GHS07, and GHS05 indicate the need for careful handling protocols and appropriate personal protective equipment during industrial operations. 2-hydroxybenzoic acid demonstrates versatility in industrial applications, primarily serving as an intermediate in pharmaceutical synthesis, particularly in the production of aspirin and other salicylate derivatives. The chemical industry utilizes this compound in the manufacture of dyes, preservatives, and various organic synthesis processes. Additionally, it finds application in the formulation of analytical reagents and as a precursor for specialized chemical compounds, sharing some application areas with related substances like 4-nitrosophenol in analytical chemistry applications. The compound's aromatic structure and dual functional groups make it valuable for chemical modifications and derivatization reactions in research and development environments. Its established regulatory profile and well-documented properties support its continued use across multiple industrial sectors. OYSI maintains reliable supply chains for 2-hydroxybenzoic acid, ensuring consistent availability for European industrial customers requiring this essential chemical intermediate.
Safety & Classification
Repr. 2; Acute Tox. 4; Eye Dam. 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Frequently Asked Questions
What is 2-hydroxybenzoic acid?
2-hydroxybenzoic acid is an organic compound with the molecular formula C7H6O3 and CAS number 69-72-7. It features a benzene ring with both carboxylic acid and hydroxyl functional groups in ortho position. With a molecular weight of 138.12 g/mol, this aromatic compound is classified as hazardous with reproductive toxicity category 2, acute toxicity category 4, and serious eye damage category 1 properties.
What are the physicochemical properties of 2-hydroxybenzoic acid?
2-hydroxybenzoic acid is typically a white crystalline solid at room temperature with a characteristic phenolic odor. It demonstrates good solubility in polar solvents like ethanol and hot water, while showing limited solubility in cold water. The compound exhibits typical aromatic acid properties due to its benzene ring structure combined with carboxylic acid and phenolic hydroxyl groups, making it amphoteric in nature.
What is 2-hydroxybenzoic acid used for?
2-hydroxybenzoic acid serves as an important intermediate in pharmaceutical synthesis and chemical manufacturing. It is commonly used in the production of various organic compounds, including pharmaceuticals, preservatives, and specialty chemicals. The compound also finds applications in analytical chemistry as a reagent and in research laboratories for organic synthesis reactions involving aromatic compounds with multiple functional groups.
How to handle 2-hydroxybenzoic acid safely?
2-hydroxybenzoic acid requires careful handling due to its hazard classification including reproductive toxicity, acute toxicity, and serious eye damage potential. Essential personal protective equipment includes chemical-resistant gloves, safety goggles or face shield, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods. Avoid direct contact with skin, eyes, and inhalation of dust or vapors during handling operations.
How to store 2-hydroxybenzoic acid correctly?
2-hydroxybenzoic acid should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. The storage area must be secure and restricted to authorized personnel due to its hazardous classification. Keep containers properly labeled and avoid storing near incompatible materials such as strong oxidizing agents, bases, or reactive metals that could cause dangerous reactions.
What to do in case of contact with 2-hydroxybenzoic acid?
Immediate action is crucial due to the serious eye damage potential of 2-hydroxybenzoic acid. For eye contact, rinse immediately with plenty of water for at least 15 minutes and seek medical attention urgently. In case of skin contact, wash thoroughly with soap and water. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical assistance while providing safety data sheet information to medical personnel.
How to dispose of 2-hydroxybenzoic acid appropriately?
2-hydroxybenzoic acid disposal must comply with local and European waste regulations due to its hazardous classification. The compound should be collected as hazardous chemical waste and disposed of through licensed waste management companies. Never dispose of this substance in regular trash, sewage systems, or soil. Containers should be properly emptied and cleaned before disposal, following established hazardous waste protocols and documentation requirements.
How to transport 2-hydroxybenzoic acid?
2-hydroxybenzoic acid transport should follow general dangerous goods regulations even though specific ADR classification data is not provided. The substance requires appropriate packaging, labeling with GHS pictograms (GHS08, GHS07, GHS05), and proper documentation during shipment. Consult current transport regulations and work with qualified logistics providers experienced in handling hazardous chemicals to ensure compliance with applicable transport requirements across European borders.
Is 2-hydroxybenzoic acid subject to specific regulations?
2-hydroxybenzoic acid is subject to European REACH and CLP regulations due to its hazardous properties including reproductive toxicity category 2. The substance requires appropriate classification, labeling, and safety data sheet provision. However, it is not currently listed as a Substance of Very High Concern (SVHC). Companies handling this chemical must comply with occupational health and safety regulations and may need authorization for certain uses.
Where to buy 2-hydroxybenzoic acid in Europe?
2-hydroxybenzoic acid is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI provides quality products with proper documentation, safety data sheets, and regulatory compliance support. Professional customers can contact OYSI directly to discuss specific requirements, quantities, and technical specifications for 2-hydroxybenzoic acid procurement across European markets with reliable supply chain management.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.