2-benzofuran-1,3-dione

C8H4O3

CAS85-44-9
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
Danger

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Identification

CAS Number
85-44-9
EC Number
201-607-5
UN Number
2214
Index Number
607-009-00-4
PubChem CID
6811

Physical-chemical properties

Molecular Formula
C8H4O3
Molar Mass
148.11 g/mol
IUPAC Name
2-benzofuran-1,3-dione

Chemical Identifiers

InChI
InChI=1S/C8H4O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H
InChI Key
LGRFSURHDFAFJT-UHFFFAOYSA-N

Overview

2-benzofuran-1,3-dione (CAS 85-44-9) is an organic anhydride compound with highly reactive carbonyl groups and significant industrial applications. This cyclic anhydride, also known by its IUPAC designation 2-benzofuran-1,3-dione, represents a crucial intermediate in organic synthesis and industrial chemistry. With the molecular formula C8H4O3 and a molecular weight of 148.11 g/mol, this compound features a benzene ring fused to a furan ring containing two carbonyl groups, making it structurally distinct from simpler anhydrides like furan-2,5-dione. The EC number 201-607-5 identifies this substance within European chemical regulations. The compound exhibits typical anhydride reactivity, readily forming derivatives through reactions with amines, alcohols, and other nucleophiles. Its chemical behavior makes it particularly valuable in polymer chemistry and pharmaceutical synthesis. However, this reactivity also contributes to its hazardous properties, requiring careful handling protocols. Safety considerations are paramount when working with 2-benzofuran-1,3-dione, as indicated by its GHS07, GHS05, and GHS08 pictograms and "Danger" signal word. The substance presents multiple health hazards including acute toxicity, skin and eye irritation, respiratory sensitization, and specific target organ toxicity. Its classification under ADR Class 8 reflects its corrosive nature during transportation. Primary industrial applications include use as a chemical intermediate in pharmaceutical manufacturing, as a curing agent in epoxy resins, and in the production of specialty polymers. The compound also serves in analytical chemistry applications and as a building block for various organic syntheses. OYSI provides reliable access to 2-benzofuran-1,3-dione for qualified industrial customers throughout Europe, ensuring compliance with all relevant safety and regulatory requirements.

Safety & Classification

Danger
Classification:

Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H315

Causes skin irritation.

H318

Causes serious eye damage.

H334

May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H317

May cause an allergic skin reaction.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2214
ADR Class8
Packing GroupIII
Tunnel CodeE
Proper Shipping NamePhthalsäureanhydrid, Maleinsäureanhydrid > 0,05 %, fest
Marine PollutantNo

Frequently Asked Questions

What is 2-benzofuran-1,3-dione?

2-benzofuran-1,3-dione is an organic chemical compound with the molecular formula C8H4O3 and CAS number 85-44-9. This substance has a molecular weight of 148.11 g/mol and belongs to the family of benzofuran derivatives. It is classified as a hazardous chemical requiring careful handling due to its toxicity, skin and eye irritation properties, and respiratory sensitization potential.

What are the physicochemical properties of 2-benzofuran-1,3-dione?

2-benzofuran-1,3-dione is a solid organic compound at room temperature with the molecular formula C8H4O3. It typically appears as white to off-white crystalline powder or flakes. The compound has a molecular weight of 148.11 g/mol and exhibits moderate solubility in organic solvents. Its benzofuran structure gives it specific chemical reactivity patterns typical of cyclic anhydrides.

What is 2-benzofuran-1,3-dione used for?

2-benzofuran-1,3-dione is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. It serves as a building block for the production of various organic compounds, including pharmaceuticals, dyes, and specialty chemicals. The compound is also utilized in research and development applications within chemical laboratories and industrial manufacturing processes requiring benzofuran derivatives.

How to handle 2-benzofuran-1,3-dione safely?

2-benzofuran-1,3-dione requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact, and wear protective clothing to prevent sensitization reactions. Always follow established safety procedures and have emergency equipment readily available.

How to store 2-benzofuran-1,3-dione correctly?

2-benzofuran-1,3-dione should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly closed and properly labeled. Store away from strong bases, alcohols, and oxidizing agents to prevent unwanted reactions. Ensure storage areas comply with local regulations for hazardous chemicals and maintain appropriate temperature control to preserve product stability.

What to do in case of contact with 2-benzofuran-1,3-dione?

In case of skin contact with 2-benzofuran-1,3-dione, immediately remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention.

How to dispose of 2-benzofuran-1,3-dione appropriately?

2-benzofuran-1,3-dione must be disposed of according to local, national, and international waste regulations as hazardous chemical waste. Contact licensed waste disposal companies specialized in chemical waste management. Do not dispose of in regular trash, sewers, or waterways. Ensure proper documentation and tracking of waste disposal activities. Consider waste minimization strategies and potential recovery or recycling options where applicable.

How to transport 2-benzofuran-1,3-dione?

2-benzofuran-1,3-dione is classified under ADR as Class 8 (corrosive substances), Packing Group III for transportation. It must be packaged in appropriate UN-approved containers with proper labeling and documentation. Transport vehicles must comply with ADR regulations for corrosive materials. Ensure proper segregation from incompatible substances and follow all applicable international transport regulations including IATA for air transport.

Is 2-benzofuran-1,3-dione subject to specific regulations?

2-benzofuran-1,3-dione is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification for hazard communication. It is not currently listed as an SVHC (Substance of Very High Concern). Manufacturers and importers must comply with safety data sheet requirements, proper labeling with GHS pictograms (GHS05, GHS07, GHS08), and workplace safety regulations for hazardous chemicals.

Where to buy 2-benzofuran-1,3-dione in Europe?

2-benzofuran-1,3-dione is available through OYSI, a European distributor specializing in technical and specialty chemicals. OYSI provides reliable supply chain management and technical support for industrial customers across Europe. Contact OYSI's technical sales team for product specifications, availability, packaging options, and delivery arrangements. Ensure compliance with local regulations and safety requirements when ordering hazardous chemicals.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.